The Medicinal Chemist’s Toolbox: An Analysis of Reactions Used in the Pursuit of Drug Candidates von Roughley, Stephen D, Jordan, Allan M

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Artificial Intelligence in Drug DesignThe Storm Before the Calm? von Jordan, Allan M

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The Histone Demethylase KDM1A Sustains the Oncogenic Potential of MLL-AF9 Leukemia Stem Cells von Harris, William J., Huang, Xu, Lynch, James T., Spencer, Gary J., Hitchin, James R., Li, Yaoyong, Ciceri, Filippo, Blaser, Julian G., Greystoke, Brigit F., Jordan, Allan M., Miller, Crispin J., Ogilvie, Donald J., Somervaille, Tim C.P.

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DNA Replication Vulnerabilities Render Ovarian Cancer Cells Sensitive to Poly(ADP-Ribose) Glycohydrolase Inhibitors von Pillay, Nisha, Tighe, Anthony, Nelson, Louisa, Littler, Samantha, Coulson-Gilmer, Camilla, Bah, Nourdine, Golder, Anya, Bakker, Bjorn, Spierings, Diana C.J., James, Dominic I., Smith, Kate M., Jordan, Allan M., Morgan, Robert D., Ogilvie, Donald J., Foijer, Floris, Jackson, Dean A., Taylor, Stephen S.

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Reversible Inhibitors of LSD1 as Therapeutic Agents in Acute Myeloid Leukemia: Clinical Significance and Progress to Date von Mould, Daniel P., McGonagle, Alison E., Wiseman, Daniel H., Williams, Emma L., Jordan, Allan M.

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Enhancer Activation by Pharmacologic Displacement of LSD1 from GFI1 Induces Differentiation in Acute Myeloid Leukemia von Maiques-Diaz, Alba, Spencer, Gary J., Lynch, James T., Ciceri, Filippo, Williams, Emma L., Amaral, Fabio M.R., Wiseman, Daniel H., Harris, William J., Li, Yaoyong, Sahoo, Sudhakar, Hitchin, James R., Mould, Daniel P., Fairweather, Emma E., Waszkowycz, Bohdan, Jordan, Allan M., Smith, Duncan L., Somervaille, Tim C.P.

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Utility of ctDNA to support patient selection for early phase clinical trials: the TARGET study von Rothwell, Dominic G., Ayub, Mahmood, Cook, Natalie, Thistlethwaite, Fiona, Carter, Louise, Dean, Emma, Smith, Nigel, Villa, Shaun, Dransfield, Joanne, Clipson, Alexandra, White, Daniel, Nessa, Kamrun, Ferdous, Saba, Howell, Matthew, Gupta, Avinash, Kilerci, Bedirhan, Mohan, Sumitra, Frese, Kris, Gulati, Sakshi, Miller, Crispin, Jordan, Allan, Eaton, Helen, Hickson, Nicholas, O’Brien, Ciara, Graham, Donna, Kelly, Claire, Aruketty, Sreeja, Metcalf, Robert, Chiramel, Jaseela, Tinsley, Nadina, Vickers, Alexander J., Kurup, Roopa, Frost, Hannah, Stevenson, Julie, Southam, Siobhan, Landers, Dónal, Wallace, Andrew, Marais, Richard, Hughes, Andrew M., Brady, Ged, Dive, Caroline, Krebs, Matthew G.

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Inhibition of Glucose-6-Phosphate Dehydrogenase Activity Attenuates Right Ventricle Pressure and Hypertrophy Elicited by VEGFR Inhibitor + Hypoxia von Kitagawa, Atsushi, Jacob, Christina, Jordan, Allan, Waddell, Ian, McMurtry, Ivan F, Gupte, Sachin A

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Mode of action of DNA-competitive small molecule inhibitors of tyrosyl DNA phosphodiesterase 2 von Hornyak, Peter, Askwith, Trevor, Walker, Sarah, Komulainen, Emilia, Paradowski, Michael, Pennicott, Lewis E, Bartlett, Edward J, Brissett, Nigel C, Raoof, Ali, Watson, Mandy, Jordan, Allan M, Ogilvie, Donald J, Ward, Simon E, Atack, John R, Pearl, Laurence H, Caldecott, Keith W, Oliver, Antony W

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ERK5 is a critical mediator of inflammation-driven cancer von Finegan, Katherine G, Perez-Madrigal, Diana, Hitchin, James R, Davies, Clare C, Jordan, Allan M, Tournier, Cathy

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Poly (ADP) Ribose Glycohydrolase Can Be Effectively Targeted in Pancreatic Cancer von Jain, Aditi, Agostini, Lebaron C, McCarthy, Grace A, Chand, Saswati N, Ramirez, AnnJosette, Nevler, Avinoam, Cozzitorto, Joseph, Schultz, Christopher W, Lowder, Cinthya Yabar, Smith, Kate M, Waddell, Ian D, Raitses-Gurevich, Maria, Stossel, Chani, Gorman, Yulia Glick, Atias, Dikla, Yeo, Charles J, Winter, Jordan M, Olive, Kenneth P, Golan, Talia, Pishvaian, Michael J, Ogilvie, Donald, James, Dominic I, Jordan, Allan M, Brody, Jonathan R

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Combining Hit Identification Strategies: Fragment-Based and in Silico Approaches to Orally Active 2-Aminothieno[2,3-d]pyrimidine Inhibitors of the Hsp90 Molecular Chaperone von Brough, Paul A, Barril, Xavier, Borgognoni, Jenifer, Chene, Patrick, Davies, Nicholas G. M, Davis, Ben, Drysdale, Martin J, Dymock, Brian, Eccles, Suzanne A, Garcia-Echeverria, Carlos, Fromont, Christophe, Hayes, Angela, Hubbard, Roderick E, Jordan, Allan M, Jensen, Michael Rugaard, Massey, Andrew, Merrett, Angela, Padfield, Antony, Parsons, Rachel, Radimerski, Thomas, Raynaud, Florence I, Robertson, Alan, Roughley, Stephen D, Schoepfer, Joseph, Simmonite, Heather, Sharp, Swee Y, Surgenor, Allan, Valenti, Melanie, Walls, Steven, Webb, Paul, Wood, Mike, Workman, Paul, Wright, Lisa

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Discovery of a first-in-class reversible DNMT1-selective inhibitor with improved tolerability and efficacy in acute myeloid leukemia von Pappalardi, Melissa B, Keenan, Kathryn, Cockerill, Mark, Kellner, Wendy A, Stowell, Alexandra, Sherk, Christian, Wong, Kristen, Pathuri, Sarath, Briand, Jacques, Steidel, Michael, Chapman, Philip, Groy, Arthur, Wiseman, Ashley K, McHugh, Charles F, Campobasso, Nino, Graves, Alan P, Fairweather, Emma, Werner, Thilo, Raoof, Ali, Butlin, Roger J, Rueda, Lourdes, Horton, John R, Fosbenner, David T, Zhang, Cunyu, Handler, Jessica L, Muliaditan, Morris, Mebrahtu, Makda, Jaworski, Jon-Paul, McNulty, Dean E, Burt, Charlotte, Eberl, H Christian, Taylor, Amy N, Ho, Thau, Merrihew, Susan, Foley, Shawn W, Rutkowska, Anna, Li, Mei, Romeril, Stuart P, Goldberg, Kristin, Zhang, Xing, Kershaw, Christopher S, Bantscheff, Marcus, Jurewicz, Anthony J, Minthorn, Elisabeth, Grandi, Paola, Patel, Mehul, Benowitz, Andrew B, Mohammad, Helai P, Gilmartin, Aidan G, Prinjha, Rab K, Ogilvie, Donald, Carpenter, Christopher, Heerding, Dirk, Baylin, Stephen B, Jones, Peter A, Cheng, Xiaodong, King, Bryan W, Luengo, Juan I, Jordan, Allan M, Waddell, Ian, Kruger, Ryan G, McCabe, Michael T

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The Neuroanatomy of the Habenular Complex and Its Role in the Regulation of Affective Behaviors von Piper, Jordan Allan, Musumeci, Giuseppe, Castorina, Alessandro

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First-in-Class Chemical Probes against Poly(ADP-ribose) Glycohydrolase (PARG) Inhibit DNA Repair with Differential Pharmacology to Olaparib von James, Dominic I, Smith, Kate M, Jordan, Allan M, Fairweather, Emma E, Griffiths, Louise A, Hamilton, Nicola S, Hitchin, James R, Hutton, Colin P, Jones, Stuart, Kelly, Paul, McGonagle, Alison E, Small, Helen, Stowell, Alexandra I. J, Tucker, Julie, Waddell, Ian D, Waszkowycz, Bohdan, Ogilvie, Donald J

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L-Proline Prevents Endoplasmic Reticulum Stress in Microglial Cells Exposed to L-azetidine-2-carboxylic Acid von Piper, Jordan Allan, Al Hammouri, Nour, Jansen, Margo Iris, Rodgers, Kenneth J, Musumeci, Giuseppe, Dhungana, Amolika, Ghorbanpour, Sahar Masoumeh, Bradfield, Laura A, Castorina, Alessandro

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Glucose 6-Phosphate Dehydrogenase from Trypanosomes: Selectivity for Steroids and Chemical Validation in Bloodstream Trypanosoma brucei von Ortíz, Cecilia, Moraca, Francesca, Laverriere, Marc, Jordan, Allan, Hamilton, Niall, Comini, Marcelo A

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Hypoxic activation of glucose-6-phosphate dehydrogenase controls the expression of genes involved in the pathogenesis of pulmonary hypertension through the regulation of DNA methyl... von Joshi, Sachindra Raj, Kitagawa, Atsushi, Jacob, Christina, Hashimoto, Ryota, Dhagia, Vidhi, Ramesh, Amrit, Zheng, Connie, Zhang, Hui, Jordan, Allan, Waddell, Ian, Leopold, Jane, Hu, Cheng-Jun, McMurtry, Ivan F, D'Alessandro, Angelo, Stenmark, Kurt R, Gupte, Sachin A

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Cell-Active Small Molecule Inhibitors of the DNA-Damage Repair Enzyme Poly(ADP-ribose) Glycohydrolase (PARG): Discovery and Optimization of Orally Bioavailable Quinazolinedione Sul... von Waszkowycz, Bohdan, Smith, Kate M, McGonagle, Alison E, Jordan, Allan M, Acton, Ben, Fairweather, Emma E, Griffiths, Louise A, Hamilton, Niall M, Hamilton, Nicola S, Hitchin, James R, Hutton, Colin P, James, Dominic I, Jones, Clifford D, Jones, Stuart, Mould, Daniel P, Small, Helen F, Stowell, Alexandra I. J, Tucker, Julie A, Waddell, Ian D, Ogilvie, Donald J

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In vitro and in vivo induction of fetal hemoglobin with a reversible and selective DNMT1 inhibitor von Gilmartin, Aidan G, Groy, Arthur, Gore, Elizabeth R, Atkins, Charity, Long, Edward R, Montoute, Monica N, Wu, Zining, Halsey, Wendy, McNulty, Dean E, Ennulat, Daniela, Rueda, Lourdes, Pappalardi, Melissa, Kruger, Ryan G, McCabe, Michael T, Raoof, Ali, Butlin, Roger, Stowell, Alexandra, Cockerill, Mark, Waddell, Ian, Ogilvie, Donald, Luengo, Juan, Jordan, Allan, Benowitz, Andrew B

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