Discovery of 4‑Aryl-5,6,7,8-tetrahydroisoquinolines as Potent, Selective, and Orally Active Aldosterone Synthase (CYP11B2) Inhibitors: In Vivo Evaluation in Rodents and Cynomolgus... von Martin, Rainer E, Aebi, Johannes D, Hornsperger, Benoit, Krebs, Hans-Jakob, Kuhn, Bernd, Kuglstatter, Andreas, Alker, André M, Märki, Hans Peter, Müller, Stephan, Burger, Dominique, Ottaviani, Giorgio, Riboulet, William, Verry, Philippe, Tan, Xuefei, Amrein, Kurt, Mayweg, Alexander V

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An Intramolecular [2 + 2] Photocycloaddition Approach to Conformationally Restricted Bis-Pyrrolidines von Fort, Diego A, Woltering, Thomas J, Alker, André M, Bach, Thorsten

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CELLOPT: improved unit‐cell parameters for electron diffraction data of small‐molecule crystals von Gruene, Tim, Clabbers, Max T. B., Luebben, Jens, Chin, Jia Min, Reithofer, Michael R., Stowasser, Frank, Alker, André M.

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Modulation of Pharmacologically Relevant Properties of Piperidine Derivatives by Functional Groups in an Equatorial or Axial β‐Position to the Amino Group von Schnider, Patrick, Dolente, Cosimo, Stalder, Henri, Martin, Rainer E., Reinmüller, Viktoria, Marty, Roman, Wyss Gramberg, Caroline, Wagner, Björn, Fischer, Holger, Alker, André M., Müller, Klaus

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Synthesis of Annulated Pyridines by Intramolecular Inverse-Electron-Demand Hetero-Diels-Alder Reaction under Superheated Continuous Flow Conditions von Martin, Rainer E., Morawitz, Falk, Kuratli, Christoph, Alker, André M., Alanine, Alexander I.

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Cytochrome P450-Mediated Metabolism and CYP Inhibition for the Synthetic Peroxide Antimalarial OZ439 von Shackleford, David M, Chiu, Francis C. K, Katneni, Kasiram, Blundell, Scott, McLaren, Jenna, Wang, Xiaofang, Zhou, Lin, Sriraghavan, Kamaraj, Alker, André M, Hunziker, Daniel, Scheurer, Christian, Zhao, Qingjie, Dong, Yuxiang, Möhrle, Jörg J, Abla, Nada, Matile, Hugues, Wittlin, Sergio, Vennerstrom, Jonathan L, Charman, Susan A

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A carbohydrate-derived trifunctional scaffold for medicinal chemistry library synthesis von Resende, Diana I. S. P., Estévez, Amalia M., Alker, Andre M., Martin, Rainer E., Wessel, Hans Peter

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Copper Coordination Chemistry of Sulfur Pendant Cyclen Derivatives: An Attempt to Hinder the Reductive-Induced Demetalation in 64/67Cu Radiopharmaceuticals von Tosato, Marianna, Dalla Tiezza, Marco, May, Nóra V, Isse, Abdirisak Ahmed, Nardella, Sonia, Orian, Laura, Verona, Marco, Vaccarin, Christian, Alker, André, Mäcke, Helmut, Pastore, Paolo, Di Marco, Valerio

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Substituted 2-oxo-azepane derivatives are potent, orally active γ-secretase inhibitors von Kitas, Eric A., Galley, Guido, Jakob-Roetne, Roland, Flohr, Alexander, Wostl, Wolfgang, Mauser, Harald, Alker, André M., Czech, Christian, Ozmen, Laurence, David-Pierson, Pascale, Reinhardt, Dieter, Jacobsen, Helmut

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RG7774 (Vicasinabin), an orally bioavailable cannabinoid receptor 2 (CB2R) agonist, decreases retinal vascular permeability, leukocyte adhesion, and ocular inflammation in animal m... von Grether, Uwe, Foxton, Richard H, Gruener, Sabine, Korn, Claudia, Kimbara, Atsushi, Osterwald, Anja, Zirwes, Elisabeth, Uhles, Sabine, Thoele, Janina, Colé, Nadine, Rogers-Evans, Mark, Röver, Stephan, Nettekoven, Matthias, Martin, Rainer E, Adam, Jean-Michel, Fingerle, Jürgen, Bissantz, Caterina, Guba, Wolfgang, Alker, André, Szczesniak, Anna M, Porter, Ross F, Toguri, Tom J, Revelant, Franco, Poirier, Agnès, Perret, Camille, Winther, Lotte, Caruso, Antonello, Fezza, Filomena, Maccarrone, Mauro, Kelly, Melanie E M, Fauser, Sascha, Ullmer, Christoph

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Is adamantane a suitable substituent to pre-organize the acid orientation in E-selectin antagonists? von Titz, Alexander, Patton, John, Alker, André M., Porro, Michele, Schwardt, Oliver, Hennig, Michael, Francotte, Eric, Magnani, John, Ernst, Beat

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Is Smaller Better? Cu2+/Cu+ Coordination Chemistry and Copper-64 Radiochemical Investigation of a 1,4,7-Triazacyclononane-Based Sulfur-Rich Chelator von Tosato, Marianna, Franchi, Sara, Isse, Abdirisak Ahmed, Del Vecchio, Alessandro, Zanoni, Giordano, Alker, André, Asti, Mattia, Gyr, Thomas, Di Marco, Valerio, Mäcke, Helmut

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Tuning the Framework of Thioether-Functionalized Polyazamacrocycles: Searching for a Chelator for Theranostic Silver Radioisotopes von Tosato, Marianna, Franchi, Sara, Dalla Tiezza, Marco, Orian, Laura, Gyr, Thomas, Alker, André, Zanoni, Giordano, Pastore, Paolo, Andrighetto, Alberto, Köster, Ulli, Jensen, Mikael, Mäcke, Helmut, Asti, Mattia, Di Marco, Valerio

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Novel Series of Dihydropyridinone P2X7 Receptor Antagonists von Lopez-Tapia, Francisco, Walker, Keith A. M, Brotherton-Pleiss, Christine, Caroon, Joanie, Nitzan, Dov, Lowrie, Lee, Gleason, Shelley, Zhao, Shu-Hai, Berger, Jacob, Cockayne, Debra, Phippard, Deborah, Suttmann, Rebecca, Fitch, William L, Bourdet, David, Rege, Pankaj, Huang, Xiaojun, Broadbent, Scott, Dvorak, Charles, Zhu, Jiang, Wagner, Paul, Padilla, Fernando, Loe, Brad, Jahangir, Alam, Alker, André

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Ring opening of cyclic sulfamidates with bromophenyl metal reagents: complementarity of sulfamidates and aziridines von Hebeisen, Paul, Weiss, Urs, Alker, André, Staempfli, Andreas

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Molecular Structure and Crystal Packing of Monofluoromethoxyarenes von Hebeisen, Paul, Weiss, Urs, Alker, André, Kuhn, Bernd, Müller, Klaus, Wang, Fang, Surya Prakash, G. K.

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Ligand channel in pharmacologically stabilized rhodopsin von Mattle, Daniel, Kuhn, Bernd, Aebi, Johannes, Bedoucha, Marc, Kekilli, Demet, Grozinger, Nathalie, Alker, Andre, Rudolph, Markus G., Schmid, Georg, Schertler, Gebhard F. X., Hennig, Michael, Standfuss, Jörg, Dawson, Roger J. P.

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Spirocyclic Oxetanes: Synthesis and Properties von Wuitschik, Georg, Rogers-Evans, Mark, Buckl, Andreas, Bernasconi, Maurizio, Märki, Moritz, Godel, Thierry, Fischer, Holger, Wagner, Björn, Parrilla, Isabelle, Schuler, Franz, Schneider, Josef, Alker, André, Schweizer, W. Bernd, Müller, Klaus, Carreira, Erick M.

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New short access to pyrrolo[2,3-c]pyridazin-6-ones via β-spirolactams von Stoll, Theodor, Alker, André, Kolczewski, Sabine, Menzi, Andrea, Revil-Baudard, Vincent

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Is Smaller Better? Cu 2+ /Cu + Coordination Chemistry and Copper-64 Radiochemical Investigation of a 1,4,7-Triazacyclononane-Based Sulfur-Rich Chelator von Tosato, Marianna, Franchi, Sara, Isse, Abdirisak Ahmed, Del Vecchio, Alessandro, Zanoni, Giordano, Alker, André, Asti, Mattia, Gyr, Thomas, Di Marco, Valerio, Mäcke, Helmut

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