Heparanase is required for activation and function of macrophages von Gutter-Kapon, Lilach, Alishekevitz, Dror, Shaked, Yuval, Li, Jin-Ping, Aronheim, Ami, Ilan, Neta, Vlodavsky, Israel

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Macrophage-Induced Lymphangiogenesis and Metastasis following Paclitaxel Chemotherapy Is Regulated by VEGFR3 von Alishekevitz, Dror, Gingis-Velitski, Svetlana, Kaidar-Person, Orit, Gutter-Kapon, Lilach, Scherer, Sandra D., Raviv, Ziv, Merquiol, Emmanuelle, Ben-Nun, Yael, Miller, Valeria, Rachman-Tzemah, Chen, Timaner, Michael, Mumblat, Yelena, Ilan, Neta, Loven, David, Hershkovitz, Dov, Satchi-Fainaro, Ronit, Blum, Galia, Sleeman, Jonathan P., Vlodavsky, Israel, Shaked, Yuval

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Host Response to Short-term, Single-Agent Chemotherapy Induces Matrix Metalloproteinase-9 Expression and Accelerates Metastasis in Mice von GINGIS-VELITSKI, Svetlana, LOVEN, David, BENAYOUN, Liat, MUNSTER, Michal, BRIL, Rotem, VOLOSHIN, Tali, ALISHEKEVITZ, Dror, BERTOLINI, Francesco, SHAKED, Yuval

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Anti-Bv8 Antibody and Metronomic Gemcitabine Improve Pancreatic Adenocarcinoma Treatment Outcome Following Weekly Gemcitabine Therapy von Hasnis, Erez, Alishekevitz, Dror, Gingis-Veltski, Svetlana, Bril, Rotem, Fremder, Ella, Voloshin, Tali, Raviv, Ziv, Karban, Amir, Shaked, Yuval

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BND-22, a first-in-class humanized ILT2-blocking antibody, promotes antitumor immunity and tumor regression von Mandel, Ilana, Haves Ziv, Dana, Goldshtein, Ilana, Peretz, Tsuri, Alishekevitz, Dror, Fridman Dror, Anna, Hakim, Motti, Hashmueli, Sharon, Friedman, Itay, Sapir, Yair, Greco, Rita, Qu, Hongjing, Nestle, Frank, Wiederschain, Dmitri, Pao, Lily, Sharma, Sharad, Ben Moshe, Tehila

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Blocking IL1β Pathway Following Paclitaxel Chemotherapy Slightly Inhibits Primary Tumor Growth but Promotes Spontaneous Metastasis von Voloshin, Tali, Alishekevitz, Dror, Kaneti, Limor, Miller, Valeria, Isakov, Elina, Kaplanov, Irena, Voronov, Elena, Fremder, Ella, Benhar, Moran, Machluf, Marcelle, Apte, Ron N, Shaked, Yuval

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Abstract 3266: BND-22, a first-in-class, anti-ILT2 monoclonal antibody inhibits the immunosuppressive effects of HLA-G and enhances anti-tumor activity of immune cells in preclinic... von Mandel, Ilana, Haves, Dana, Goldshtein, Ilana, Peretz, Tsuri, Alishekevitz, Dror, Sapir, Yair, Hashmueli, Sharon, Friedman, Itay, Moshe, Tehila Ben

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Abstract 2846A: CD28 shedding is a novel immune-regulatory mechanism found in cancer patients which directly inhibits anti PD-1 effect von Hakim, Motti, Dror, Anna Fridman, Alishekevitz, Dror, Meilin, Edna, Shilovizky, Orit, Weber, Jeffrey S., Sapir, Yair, Shulman, Avidor, Moshe, Tehila Ben

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Evaluation of pharmacodynamic and patient enrichment biomarkers for SAR444881, a first-in-class anti-ILT2 monoclonal antibody for cancer immunotherapy von Mandel, Ilana, Wang, Rui, Caron, Anne, Marquez, Eladio, Dib, Colette, Jackson, Donald, Deantonio, Cecilia, Haves, Dana, Goldshtein, Ilana, Peretz, Tsuri, Alishekevitz, Dror, Hashmueli, Sharon, Sapir, Yair, Ben Moshe, Tehila, Abbadessa, Giovanni, Friedman, Itay, Crawford, Nigel

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Bortezomib-induced pro-inflammatory macrophages as a potential factor limiting anti-tumour efficacy von Beyar-Katz, Ofrat, Magidey, Ksenia, Ben-Tsedek, Neta, Alishekevitz, Dror, Timaner, Michael, Miller, Valeria, Lindzen, Moshit, Yarden, Yosef, Avivi, Irit, Shaked, Yuval

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Dose- and time-dependence of the host-mediated response to paclitaxel therapy: a mathematical modeling approach von Benguigui, Madeleine, Alishekevitz, Dror, Timaner, Michael, Shechter, Dvir, Raviv, Ziv, Benzekry, Sebastien, Shaked, Yuval

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Tumor‐derived microparticles induce bone marrow‐derived cell mobilization and tumor homing: A process regulated by osteopontin von Fremder, Ella, Munster, Michal, Aharon, Anat, Miller, Valeria, Gingis‐Velitski, Svetlana, Voloshin, Tali, Alishekevitz, Dror, Bril, Rotem, Scherer, Stefan J., Loven, David, Brenner, Benjamin, Shaked, Yuval

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Dequalinium blocks macrophage-induced metastasis following local radiation von Timaner, Michael, Bril, Rotem, Kaidar-Person, Orit, Rachman-Tzemah, Chen, Alishekevitz, Dror, Kotsofruk, Ruslana, Miller, Valeria, Nevelsky, Alexander, Daniel, Shahar, Raviv, Ziv, Rotenberg, Susan A, Shaked, Yuval

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Abstract 654: CD28 shedding is a novel resistance mechanism to anti PD-1 therapy von Hakim, Motti, Dror, Anna Fridman, Gabay, Tal Shahar, Alishekevitz, Dror, Meilin, Edna, Mandel, Ilana, Sapir, Yair, Shulman, Avidor, Moshe, Tehila Ben

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Bortezomib-Induced Proinflammatory Macrophages Contribute to Multiple Myeloma Cell Aggressiveness von Beyar Katz, Ofrat, Ben-Tsedek, Neta, Avivi, Irit, Alishekevitz, Dror, Timaner, Michael, Miller, Valeria, Lindzen, Moshit, Yarden, Yosef, Shaked, Yuval

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Host JDP2 expression in the bone marrow contributes to metastatic spread von Barbarov, Yelena, Timaner, Michael, Alishekevitz, Dror, Hai, Tsonwin, Yokoyama, Kazunari K, Shaked, Yuval, Aronheim, Ami

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Bortezomib-induced pro-inflammatory macrophages as a potential factor limiting anti-tumour efficacy: Bortezomib-induced MM aggressiveness von Beyar-Katz, Ofrat, Magidey, Ksenia, Ben-Tsedek, Neta, Alishekevitz, Dror, Timaner, Michael, Miller, Valeria, Lindzen, Moshit, Yarden, Yosef, Avivi, Irit, Shaked, Yuval

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Differential therapeutic effects of anti-VEGF-A antibody in different tumor models: implications for choosing appropriate tumor models for drug testing von Alishekevitz, Dror, Bril, Rotem, Loven, David, Miller, Valeria, Voloshin, Tali, Gingis-Velistki, Svetlana, Fremder, Ella, Scherer, Stefan J, Shaked, Yuval

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Abstract LB-343: Host response to paclitaxel chemotherapy promotes metastasis via the secretion of VEGF-C by macrophages von Gingis-Velitski, Svetlana, Kaidar-Person, Orit, Alishekevitz, Dror, Bril, Rotem, Fremder, Ella, Shaked, Yuval

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Abstract B59: The dual effect of therapy-induced IL-1β expression on tumor progression: Role of tumor-associated macrophages von Voloshin, Tali, Alishekevitz, Dror, Miller, Valeria, Isakov, Lika, Bril, Rotem, Benhar, Moran, Apte, Roney, Shaked, Yuval

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