Potent quinoxaline-Based inhibitors of PDGF receptor tyrosine kinase activity. Part 2: the synthesis and biological activities of RPR127963 an orally bioavailable inhibitor von He, Wei, Myers, Michael R., Hanney, Barbara, Spada, Alfred P., Bilder, Glenda, Galzcinski, Helen, Amin, Dilip, Needle, Saul, Page, Ken, Jayyosi, Zaid, Perrone, Mark H.

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Emricasan (IDN‐6556) Lowers Portal Pressure in Patients With Compensated Cirrhosis and Severe Portal Hypertension von Garcia‐Tsao, Guadalupe, Fuchs, Michael, Shiffman, Mitchell, Borg, Brian B., Pyrsopoulos, Nikolaos, Shetty, Kirti, Gallegos‐Orozco, Juan F., Reddy, K. Rajender, Feyssa, Eyob, Chan, Jean L., Yamashita, Mason, Robinson, James M., Spada, Alfred P., Hagerty, David T., Bosch, Jaime

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Emricasan Improves Liver Function in Patients With Cirrhosis and High Model for End-Stage Liver Disease Scores Compared With Placebo von Frenette, Catherine T., Morelli, Giuseppe, Shiffman, Mitchell L., Frederick, R. Todd, Rubin, Raymond A., Fallon, Michael B., Cheng, Jason T., Cave, Matt, Khaderi, Saira A., Massoud, Omar, Pyrsopoulos, Nikolaos, Park, James S., Robinson, James M., Yamashita, Mason, Spada, Alfred P., Chan, Jean L., Hagerty, David T.

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A New Series of PDGF Receptor Tyrosine Kinase Inhibitors: 3-Substituted Quinoline Derivatives von Maguire, Martin P, Sheets, Kimberly R, McVety, Karen, Spada, Alfred P, Zilberstein, Asher

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Caspase Inhibition Reduces Hepatic Tissue Factor-Driven Coagulation In Vitro and In Vivo von Kopec, Anna K, Spada, Alfred P, Contreras, Patricia C, Mackman, Nigel, Luyendyk, James P

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Structural and Functional Analysis of Caspase Active Sites von Chéreau, David, Kodandapani, Lalitha, Tomaselli, Kevin J, Spada, Alfred P, Wu, Joe C

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Potent quinoxaline-Based inhibitors of PDGF receptor tyrosine kinase activity. Part 1: SAR Exploration and Effective Bioisosteric Replacement of a phenyl substituent von Myers, Michael R., He, Wei, Hanney, Barbara, Setzer, Natalie, Maguire, Martin P., Zulli, Allison, Bilder, Glenda, Galzcinski, Helen, Amin, Dilip, Needle, Saul, Spada, Alfred P.

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Molecular Structures of Human Factor Xa Complexed with Ketopiperazine Inhibitors:  Preference for a Neutral Group in the S1 Pocket von Maignan, Sébastien, Guilloteau, Jean-Pierre, Choi-Sledeski, Yong Mi, Becker, Michael R, Ewing, William R, Pauls, Henry W, Spada, Alfred P, Mikol, Vincent

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Crystal Structures of Human Factor Xa Complexed with Potent Inhibitors von Maignan, Sébastien, Guilloteau, Jean-Pierre, Pouzieux, Stéphanie, Choi-Sledeski, Yong Mi, Becker, Michael R, Klein, Scott I, Ewing, William R, Pauls, Henry W, Spada, Alfred P, Mikol, Vincent

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In Vitro Characterization of a Novel Factor Xa Inhibitor, RPR 130737 von Chu, Valeria, Brown, Karen, Colussi, Dennis, Choi, Yong-Mi, Green, Dan, Pauls, Henry W, Spada, Alfred P, Perrone, Mark H, Leadley, Robert J, Dunwiddie, Christopher T

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Optimization of the β-Aminoester class of factor Xa inhibitors. part 2: Identification of FXV673 as a potent and selective inhibitor with excellent In vivo anticoagulant activity von Guertin, Kevin R, Gardner, Charles J, Klein, Scott I, Zulli, Allison L, Czekaj, Mark, Gong, Yong, Spada, Alfred P, Cheney, Daniel L, Maignan, Sebastian, Guilloteau, Jean-Pierre, Brown, Karen D, Colussi, Dennis J, Chu, Valeria, Heran, Christopher L, Morgan, Suzanne R, Bentley, Ross G, Dunwiddie, Christopher T, Leadley, Robert J, Pauls, Henry W

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Conformational restrictions in the active site of unliganded human caspase-3 von Ni, Chao-Zhou, Li, Chenglong, Wu, Joe C., Spada, Alfred P., Ely, Kathryn R.

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A Nucleotide Binding Site in Caspase-9 Regulates Apoptosome Activation von Chereau, David, Zou, Hua, Spada, Alfred P, Wu, Joe C

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The antiproliferative effects of tyrosine kinase inhibitors tyrphostins on a human squamous cell carcinoma in vitro and in nude mice von YONEDA, T, LYALL, R. M, ALSINA, M. M, PERSONS, P. E, SPADA, A. P, LEVITZKI, A, ZILBERSTEIN, A, MUNDY, G. R

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Identification and Initial Structure−Activity Relationships of a Novel Class of Nonpeptide Inhibitors of Blood Coagulation Factor Xa von Klein, Scott I, Czekaj, Mark, Gardner, Charles J, Guertin, Kevin R, Cheney, Daniel L, Spada, Alfred P, Bolton, Scott A, Brown, Karen, Colussi, Dennis, Heran, Christopher L, Morgan, Suzanne R, Leadley, Robert J, Dunwiddie, Christopher T, Perrone, Mark H, Chu, Valeria

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Optimization of the β-aminoester class of factor Xa inhibitors. Part 1: P4 and side-chain modifications for improved in vitro potency von CZEKAJ, Mark, KLEIN, Scott I, CHU, Valeria, LEADLEY, Robert J, DUNWIDDIE, Christopher T, GUERTIN, Kevin R, GARDNER, Charles J, ZULLI, Allison L, PAULS, Henry W, SPADA, Alfred P, CHENEY, Daniel L, BROWN, Karen D, COLUSSI, Dennis J

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Nonbenzamidine compounds as selective factor xa inhibitors von He, Wei, Hanney, Barbara, Myers, Michael R, Spada, Alfred P, Brown, Karen, Colussi, Dennis, Chu, Valeria

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Benzimidazoles and isosteric compounds as potent and selective factor Xa inhibitors von WEI HE, HANNEY, Barbara, MYERS, Michael R, CONDON, Stephen, BECKER, Michael R, SPADA, Alfred P, BURNS, Christopher, BROWN, Karen, COLUSSI, Dennis, CHU, Valeria

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First-in-Class Pan Caspase Inhibitor Developed for the Treatment of Liver Disease von Linton, Steven D, Aja, Teresa, Armstrong, Robert A, Bai, Xu, Chen, Long-Shiuh, Chen, Ning, Ching, Brett, Contreras, Patricia, Diaz, Jose-Luis, Fisher, Craig D, Fritz, Lawrence C, Gladstone, Patricia, Groessl, Todd, Gu, Xin, Herrmann, Julia, Hirakawa, Brad P, Hoglen, Niel C, Jahangiri, Kathy G, Kalish, Vincent J, Karanewsky, Donald S, Kodandapani, Lalitha, Krebs, Joseph, McQuiston, Jeff, Meduna, Steven P, Nalley, Kip, Robinson, Edward D, Sayers, Robert O, Sebring, Kristen, Spada, Alfred P, Ternansky, Robert J, Tomaselli, Kevin J, Ullman, Brett R, Valentino, Karen L, Weeks, Suzanne, Winn, David, Wu, Joe C, Yeo, Pauline, Zhang, Cheng-zhi

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Pharmacodynamic Activity and Antithrombotic Efficacy of RPR120844, a Novel Inhibitor of Coagulation Factor Xa von Leadley, Robert J, Morgan, Suzanne R, Bentley, Ross, Bostwick, Jeffrey S, Kasiewski, Charles J, Heran, Christopher, Chu, Valeria, Brown, Karen, Moxey, Phillip, Ewing, W Richard, Pauls, Henry, Spada, Alfred P, Perrone, Mark H, Dunwiddie, Christopher T

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