LRRK2 kinase in Parkinson's disease von Alessi, Dario R, Sammler, Esther

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Advances in elucidating the function of leucine-rich repeat protein kinase-2 in normal cells and Parkinson's disease von Taylor, Matthew, Alessi, Dario R.

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LKB1 and AMPK and the cancer-metabolism link - ten years after von Hardie, D Grahame, Alessi, Dario R

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The selectivity of protein kinase inhibitors: a further update von Bain, Jenny, Plater, Lorna, Elliott, Matt, Shpiro, Natalia, Hastie, C James, McLauchlan, Hilary, Klevernic, Iva, Arthur, J Simon C, Alessi, Dario R, Cohen, Philip

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Kinase Drug Discovery – What’s Next in the Field? von Cohen, Philip, Alessi, Dario R

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mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1) von García-Martínez, Juan M, Alessi, Dario R

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The IkappaB kinase family phosphorylates the Parkinson's disease kinase LRRK2 at Ser935 and Ser910 during Toll-like receptor signaling von Dzamko, Nicolas, Inesta-Vaquera, Francisco, Zhang, Jiazhen, Xie, Chengsong, Cai, Huaibin, Arthur, Simon, Tan, Li, Choi, Hwanguen, Gray, Nathanael, Cohen, Philip, Pedrioli, Patrick, Clark, Kristopher, Alessi, Dario R

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The nuts and bolts of AGC protein kinases von Pearce, Laura R, Komander, David, Alessi, Dario R

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Rab29 activation of the Parkinson's disease‐associated LRRK2 kinase von Purlyte, Elena, Dhekne, Herschel S, Sarhan, Adil R, Gomez, Rachel, Lis, Pawel, Wightman, Melanie, Martinez, Terina N, Tonelli, Francesca, Pfeffer, Suzanne R, Alessi, Dario R

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Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation von Maniaci, Chiara, Hughes, Scott J., Testa, Andrea, Chen, Wenzhang, Lamont, Douglas J., Rocha, Sonia, Alessi, Dario R., Romeo, Roberto, Ciulli, Alessio

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PDK1-SGK1 Signaling Sustains AKT-Independent mTORC1 Activation and Confers Resistance to PI3Kα Inhibition von Castel, Pau, Ellis, Haley, Bago, Ruzica, Toska, Eneda, Razavi, Pedram, Carmona, F. Javier, Kannan, Srinivasaraghavan, Verma, Chandra S., Dickler, Maura, Chandarlapaty, Sarat, Brogi, Edi, Alessi, Dario R., Baselga, José, Scaltriti, Maurizio

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Phos-tag analysis of Rab10 phosphorylation by LRRK2: a powerful assay for assessing kinase function and inhibitors von Ito, Genta, Katsemonova, Kristina, Tonelli, Francesca, Lis, Pawel, Baptista, Marco A S, Shpiro, Natalia, Duddy, Graham, Wilson, Steve, Ho, Philip Wing-Lok, Ho, Shu-Leong, Reith, Alastair D, Alessi, Dario R

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Rab29-dependent asymmetrical activation of leucine-rich repeat kinase 2 von Zhu, Hanwen, Tonelli, Francesca, Turk, Martin, Prescott, Alan, Alessi, Dario R, Sun, Ji

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regulation of salt transport and blood pressure by the WNK-SPAK/OSR1 signalling pathway von Richardson, Ciaran, Alessi, Dario R

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The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K+-Cl- co-transporters von de Los Heros, Paola, Alessi, Dario R, Gourlay, Robert, Campbell, David G, Deak, Maria, Macartney, Thomas J, Kahle, Kristopher T, Zhang, Jinwei

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Selective Requirement of PI3K/PDK1 Signaling for Kras Oncogene-Driven Pancreatic Cell Plasticity and Cancer von Eser, Stefan, Reiff, Nina, Messer, Marlena, Seidler, Barbara, Gottschalk, Kathleen, Dobler, Melanie, Hieber, Maren, Arbeiter, Andreas, Klein, Sabine, Kong, Bo, Michalski, Christoph W., Schlitter, Anna Melissa, Esposito, Irene, Kind, Alexander J., Rad, Lena, Schnieke, Angelika E., Baccarini, Manuela, Alessi, Dario R., Rad, Roland, Schmid, Roland M., Schneider, Günter, Saur, Dieter

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14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization von Nichols, R Jeremy, Dzamko, Nicolas, Morrice, Nicholas A, Campbell, David G, Deak, Maria, Ordureau, Alban, Macartney, Thomas, Tong, Youren, Shen, Jie, Prescott, Alan R, Alessi, Dario R

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The WNK-SPAK/OSR1 pathway: master regulator of cation-chloride cotransporters von Alessi, Dario R, Zhang, Jinwei, Khanna, Arjun, Hochdörfer, Thomas, Shang, Yuze, Kahle, Kristopher T

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Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis von Steger, Martin, Diez, Federico, Dhekne, Herschel S, Lis, Pawel, Nirujogi, Raja S, Karayel, Ozge, Tonelli, Francesca, Martinez, Terina N, Lorentzen, Esben, Pfeffer, Suzanne R, Alessi, Dario R, Mann, Matthias

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Characterization of VPS34-IN1, a selective inhibitor of Vps34, reveals that the phosphatidylinositol 3-phosphate-binding SGK3 protein kinase is a downstream target of class III pho... von Bago, Ruzica, Malik, Nazma, Munson, Michael J, Prescott, Alan R, Davies, Paul, Sommer, Eeva, Shpiro, Natalia, Ward, Richard, Cross, Darren, Ganley, Ian G, Alessi, Dario R

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