14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization von Nichols, R Jeremy, Dzamko, Nicolas, Morrice, Nicholas A, Campbell, David G, Deak, Maria, Ordureau, Alban, Macartney, Thomas, Tong, Youren, Shen, Jie, Prescott, Alan R, Alessi, Dario R

Volltext

Randomized Trial of Continuous Subcutaneous Delivery of Exenatide by ITCA 650 Versus Twice-Daily Exenatide Injections in Metformin-Treated Type 2 Diabetes von HENRY, Robert R, ROSENSTOCK, Julio, LOGAN, Douglas K, ALESSI, Thomas R, LUSKEY, Kenneth, BARON, Michelle A

Volltext

The WNK-SPAK/OSR1 pathway: master regulator of cation-chloride cotransporters von Alessi, Dario R, Zhang, Jinwei, Khanna, Arjun, Hochdörfer, Thomas, Shang, Yuze, Kahle, Kristopher T

Volltext

DUROS technology delivers peptides and proteins at consistent rate continuously for 3 to 12 months von Rohloff, Catherine M, Alessi, Thomas R, Yang, Bing, Dahms, Janice, Carr, John P, Lautenbach, Scott D

Volltext

Continuous Subcutaneous Delivery of a Glucagon Analog, ICA6150349, to Rats and Nonhuman Primates Demonstrates Safety and Tolerability in a 14-Day Toxicity Study von ZANE, DORIS, SINGH, ROSHNI, SHELTON, JOSEPHINE, ROLLER, SHANE, PAULIK, MARK, WAY, JAMES, BLACKWELL, WILLIAM C., SRIVASTAVA, VED, HODGE, REBECCA, FELDMAN, PAUL L., ALESSI, THOMAS R.

Volltext

High-Resolution Structure of the Pleckstrin Homology Domain of Protein Kinase B/Akt Bound to Phosphatidylinositol (3,4,5)-Trisphosphate von Thomas, Christine C, Deak, Maria, Alessi, Dario R, van Aalten, Daan M.F

Volltext

Stereocontrol in the intramolecular Diels-Alder reaction. 3. A potentially general method for the synthesis of cis-hydrindenes by use of (Z)-diene units von Boeckman, R. K, Alessi, Thomas R

Volltext

Randomized Trial of Continuous Subcutaneous Delivery of Exenatide by ITCA 650 Versus Twice-Daily Exenatide Injections in Metformin-Treated Type 2 Diabetes. Diabetes Care 2013;36:25... von Henry, Robert R., Rosenstock, Julio, Logan, Douglas K., Alessi, Thomas R., Luskey, Kenneth, Baron, Michelle A.

Volltext

Synthetic studies directed toward naturally occurring cyclooctanoids. 2. A stereocontrolled assembly of (.+-.)-pleuromutilin via a remarkable sterically demanding oxy-Cope rearrang... von Boeckman, Robert K, Springer, Dane M, Alessi, Thomas R

Volltext

Correction to "Development of BromoTag: A "Bump-and-Hole"-PROTAC System To Induce Potent, Rapid, and Selective Degradation of Tagged Target Proteins" von Bond, Adam G, Craigon, Conner, Chan, Kwok-Ho, Testa, Andrea, Karapetsas, Athanasios, Fasimoye, Rotimi, Macartney, Thomas, Blow, J Julian, Alessi, Dario R, Ciulli, Alessio

Volltext

Mechanism of activation of SGK3 by growth factors via the Class 1 and Class 3 PI3Ks von Malik, Nazma, Macartney, Thomas, Hornberger, Annika, Anderson, Karen E, Tovell, Hannah, Prescott, Alan R, Alessi, Dario R

Volltext

Antihyperglycemic activity of novel substituted 3H-1,2,3,5-oxathiadiazole 2-oxides von Ellingboe, John W, Alessi, Thomas R, Dolak, Terence M, Nguyen, Thomas T, Tomer, John D, Guzzo, Frieda, Bagli, Jehan F, McCaleb, Michael L

Volltext

USP45 deubiquitylase controls ERCC1-XPF endonuclease-mediated DNA damage responses von Perez-Oliva, Ana B, Lachaud, Christophe, Szyniarowski, Piotr, Muñoz, Ivan, Macartney, Thomas, Hickson, Ian, Rouse, John, Alessi, Dario R

Volltext

Randomized trial of continuous subcutaneous delivery of exenatide by ITCA 650 versus twice-daily exenatide injections in metformin-treated type 2 diabetes von Henry, Robert R, Rosenstock, Julio, Logan, Douglas K, Alessi, Thomas R, Luskey, Kenneth, Baron, Michelle A

Volltext

The Parkinson's disease VPS35[D620N] mutation enhances LRRK2-mediated Rab protein phosphorylation in mouse and human von Mir, Rafeeq, Tonelli, Francesca, Lis, Pawel, Macartney, Thomas, Polinski, Nicole K, Martinez, Terina N, Chou, Meng-Yun, Howden, Andrew J M, König, Theresa, Hotzy, Christoph, Milenkovic, Ivan, Brücke, Thomas, Zimprich, Alexander, Sammler, Esther, Alessi, Dario R

Volltext

USP 45 deubiquitylase controls ERCC 1– XPF endonuclease‐mediated DNA damage responses von Perez‐Oliva, Ana B, Lachaud, Christophe, Szyniarowski, Piotr, Muñoz, Ivan, Macartney, Thomas, Hickson, Ian, Rouse, John, Alessi, Dario R

Volltext

Phosphoproteomics reveals that the hVPS34 regulated SGK3 kinase specifically phosphorylates endosomal proteins including Syntaxin-7, Syntaxin-12, RFIP4 and WDR44 von Malik, Nazma, Nirujogi, Raja S, Peltier, Julien, Macartney, Thomas, Wightman, Melanie, Prescott, Alan R, Gourlay, Robert, Trost, Matthias, Alessi, Dario R, Karapetsas, Athanasios

Volltext

Rapid establishment and/or termination of substantial steady-state drug delivery von Luskey, Kenneth, Alessi, Thomas R

Volltext bestellen

A Randomized, Open-Label, Multicenter, 4-Week Study to Evaluate the Tolerability and Pharmacokinetics of ITCA 650 in Patients With Type 2 Diabetes☆☆This is an open-access article d... von Henry, Robert R., Logan, Douglas, Alessi, Thomas, Baron, Michelle A.

Volltext

RAPID ESTABLISHMENT AND/OR TERMINATION OF SUBSTANTIAL STEADY-STATE DRUG DELIVERY von Luskey, Kenneth, Alessi, Thomas R

Volltext bestellen