LRRK2 kinase in Parkinson's disease von Alessi, Dario R, Sammler, Esther

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Advances in elucidating the function of leucine-rich repeat protein kinase-2 in normal cells and Parkinson's disease von Taylor, Matthew, Alessi, Dario R.

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mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1) von García-Martínez, Juan M, Alessi, Dario R

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LKB1 and AMPK and the cancer-metabolism link - ten years after von Hardie, D Grahame, Alessi, Dario R

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Rab29 activation of the Parkinson's disease‐associated LRRK2 kinase von Purlyte, Elena, Dhekne, Herschel S, Sarhan, Adil R, Gomez, Rachel, Lis, Pawel, Wightman, Melanie, Martinez, Terina N, Tonelli, Francesca, Pfeffer, Suzanne R, Alessi, Dario R

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The selectivity of protein kinase inhibitors: a further update von Bain, Jenny, Plater, Lorna, Elliott, Matt, Shpiro, Natalia, Hastie, C James, McLauchlan, Hilary, Klevernic, Iva, Arthur, J Simon C, Alessi, Dario R, Cohen, Philip

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Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation von Maniaci, Chiara, Hughes, Scott J., Testa, Andrea, Chen, Wenzhang, Lamont, Douglas J., Rocha, Sonia, Alessi, Dario R., Romeo, Roberto, Ciulli, Alessio

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The IkappaB kinase family phosphorylates the Parkinson's disease kinase LRRK2 at Ser935 and Ser910 during Toll-like receptor signaling von Dzamko, Nicolas, Inesta-Vaquera, Francisco, Zhang, Jiazhen, Xie, Chengsong, Cai, Huaibin, Arthur, Simon, Tan, Li, Choi, Hwanguen, Gray, Nathanael, Cohen, Philip, Pedrioli, Patrick, Clark, Kristopher, Alessi, Dario R

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Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis von Steger, Martin, Diez, Federico, Dhekne, Herschel S, Lis, Pawel, Nirujogi, Raja S, Karayel, Ozge, Tonelli, Francesca, Martinez, Terina N, Lorentzen, Esben, Pfeffer, Suzanne R, Alessi, Dario R, Mann, Matthias

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Phos-tag analysis of Rab10 phosphorylation by LRRK2: a powerful assay for assessing kinase function and inhibitors von Ito, Genta, Katsemonova, Kristina, Tonelli, Francesca, Lis, Pawel, Baptista, Marco A S, Shpiro, Natalia, Duddy, Graham, Wilson, Steve, Ho, Philip Wing-Lok, Ho, Shu-Leong, Reith, Alastair D, Alessi, Dario R

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PDK1-SGK1 Signaling Sustains AKT-Independent mTORC1 Activation and Confers Resistance to PI3Kα Inhibition von Castel, Pau, Ellis, Haley, Bago, Ruzica, Toska, Eneda, Razavi, Pedram, Carmona, F. Javier, Kannan, Srinivasaraghavan, Verma, Chandra S., Dickler, Maura, Chandarlapaty, Sarat, Brogi, Edi, Alessi, Dario R., Baselga, José, Scaltriti, Maurizio

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The WNK-SPAK/OSR1 pathway: master regulator of cation-chloride cotransporters von Alessi, Dario R, Zhang, Jinwei, Khanna, Arjun, Hochdörfer, Thomas, Shang, Yuze, Kahle, Kristopher T

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Structural Basis for Rab8a Recruitment of RILPL2 via LRRK2 Phosphorylation of Switch 2 von Waschbüsch, Dieter, Purlyte, Elena, Pal, Prosenjit, McGrath, Emma, Alessi, Dario R., Khan, Amir R.

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Development of a multiplexed targeted mass spectrometry assay for LRRK2-phosphorylated Rabs and Ser910/Ser935 biomarker sites von Nirujogi, Raja S, Tonelli, Francesca, Taylor, Matthew, Lis, Pawel, Zimprich, Alexander, Sammler, Esther, Alessi, Dario R

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14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization von Nichols, R Jeremy, Dzamko, Nicolas, Morrice, Nicholas A, Campbell, David G, Deak, Maria, Ordureau, Alban, Macartney, Thomas, Tong, Youren, Shen, Jie, Prescott, Alan R, Alessi, Dario R

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The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K+-Cl- co-transporters von de Los Heros, Paola, Alessi, Dario R, Gourlay, Robert, Campbell, David G, Deak, Maria, Macartney, Thomas J, Kahle, Kristopher T, Zhang, Jinwei

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Selective Requirement of PI3K/PDK1 Signaling for Kras Oncogene-Driven Pancreatic Cell Plasticity and Cancer von Eser, Stefan, Reiff, Nina, Messer, Marlena, Seidler, Barbara, Gottschalk, Kathleen, Dobler, Melanie, Hieber, Maren, Arbeiter, Andreas, Klein, Sabine, Kong, Bo, Michalski, Christoph W., Schlitter, Anna Melissa, Esposito, Irene, Kind, Alexander J., Rad, Lena, Schnieke, Angelika E., Baccarini, Manuela, Alessi, Dario R., Rad, Roland, Schmid, Roland M., Schneider, Günter, Saur, Dieter

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Elevated SGK1 predicts resistance of breast cancer cells to Akt inhibitors von Sommer, Eeva M, Dry, Hannah, Cross, Darren, Guichard, Sylvie, Davies, Barry R, Alessi, Dario R

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Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases von Steger, Martin, Tonelli, Francesca, Ito, Genta, Davies, Paul, Trost, Matthias, Vetter, Melanie, Wachter, Stefanie, Lorentzen, Esben, Duddy, Graham, Wilson, Stephen, Baptista, Marco As, Fiske, Brian K, Fell, Matthew J, Morrow, John A, Reith, Alastair D, Alessi, Dario R, Mann, Matthias

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A pathway for Parkinson's Disease LRRK2 kinase to block primary cilia and Sonic hedgehog signaling in the brain von Dhekne, Herschel S, Yanatori, Izumi, Gomez, Rachel C, Tonelli, Francesca, Diez, Federico, Schüle, Birgitt, Steger, Martin, Alessi, Dario R, Pfeffer, Suzanne R

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