Targeting the m6A RNA modification pathway blocks SARS-CoV-2 and HCoV-OC43 replication von Burgess, Hannah M., Depledge, Daniel P., Thompson, Letitia, Srinivas, Kalanghad Puthankalam, Grande, Rebecca C., Vink, Elizabeth I., Abebe, Jonathan S., Blackaby, Wesley P., Hendrick, Alan, Albertella, Mark R., Kouzarides, Tony, Stapleford, Kenneth A., Wilson, Angus C., Mohr, Ian

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Inhibition of METTL3 Results in a Cell-Intrinsic Interferon Response That Enhances Antitumor Immunity von Guirguis, Andrew A., Ofir-Rosenfeld, Yaara, Knezevic, Kathy, Blackaby, Wesley, Hardick, David, Chan, Yih-Chih, Motazedian, Ali, Gillespie, Andrea, Vassiliadis, Dane, Lam, Enid Y.N., Tran, Kevin, Andrews, Byron, Harbour, Michael E., Vasiliauskaite, Lina, Saunders, Claire J., Tsagkogeorga, Georgia, Azevedo, Aleksandra, Obacz, Joanna, Pilka, Ewa S., Carkill, Marie, MacPherson, Laura, Wainwright, Elanor N., Liddicoat, Brian, Blyth, Benjamin J., Albertella, Mark R., Rausch, Oliver, Dawson, Mark A.

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The overexpression of specialized DNA polymerases in cancer von Albertella, Mark R., Lau, Alan, O’Connor, Mark J.

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Design and Preclinical Evaluation of a Novel B7-H4-Directed Antibody-Drug Conjugate, AZD8205, Alone and in Combination with the PARP1-Selective Inhibitor AZD5305 von Kinneer, Krista, Wortmann, Philipp, Cooper, Zachary A, Dickinson, Niall J, Masterson, Luke, Cailleau, Thais, Hutchinson, Ian, Vijayakrishnan, Balakumar, McFarlane, Mary, Ball, Kathryn, Davies, Michael, Lewis, Arthur, Huang, Yue, Rosenbaum, Anton I, Yuan, Jiaqi, Chesebrough, Jon, Anderton, Judith, Monks, Noel, Novick, Steven, Wang, Jixin, Dimasi, Nazzareno, Christie, R James, Sabol, Darrin, Tosto, Frances Anne, Wallez, Yann, Leo, Elisabetta, Albertella, Mark R, Staniszewska, Anna D, Tice, David A, Howard, Philip W, Luheshi, Nadia, Sapra, Puja

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The RON Receptor Tyrosine Kinase Promotes Metastasis by Triggering MBD4-Dependent DNA Methylation Reprogramming von Cunha, Stéphanie, Lin, Yi-Chun, Goossen, Elizabeth A., DeVette, Christa I., Albertella, Mark R., Thomson, Stuart, Mulvihill, Mark J., Welm, Alana L.

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A role for polymerase eta in the cellular tolerance to cisplatin-induced damage von Albertella, Mark R, Green, Catherine M, Lehmann, Alan R, O'Connor, Mark J

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Targeting the m 6 A RNA modification pathway blocks SARS-CoV-2 and HCoV-OC43 replication von Burgess, Hannah M, Depledge, Daniel P, Thompson, Letitia, Srinivas, Kalanghad Puthankalam, Grande, Rebecca C, Vink, Elizabeth I, Abebe, Jonathan S, Blackaby, Wesley P, Hendrick, Alan, Albertella, Mark R, Kouzarides, Tony, Stapleford, Kenneth A, Wilson, Angus C, Mohr, Ian

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The PARP1 selective inhibitor saruparib (AZD5305) elicits potent and durable antitumor activity in patient-derived BRCA1/2-associated cancer models von Herencia-Ropero, Andrea, Llop-Guevara, Alba, Staniszewska, Anna D, Domènech-Vivó, Joanna, García-Galea, Eduardo, Moles-Fernández, Alejandro, Pedretti, Flaminia, Domènech, Heura, Rodríguez, Olga, Guzmán, Marta, Arenas, Enrique J, Verdaguer, Helena, Calero-Nieto, Fernando J, Talbot, Sara, Tobalina, Luis, Leo, Elisabetta, Lau, Alan, Nuciforo, Paolo, Dienstmann, Rodrigo, Macarulla, Teresa, Arribas, Joaquín, Díez, Orland, Gutiérrez-Enríquez, Sara, Forment, Josep V, O'Connor, Mark J, Albertella, Mark, Balmaña, Judith, Serra, Violeta

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Novel L-nucleoside analogue, 5-fluorotroxacitabine, displays potent efficacy against acute myeloid leukemia von Bankar, Aniket, Siriwardena, Thirushi Piyumika, Rizoska, Biljana, Rydergård, Christina, Kylefjord, Helen, Rraklli, Vilma, Eneroth, Anders, Pinho, Pedro, Norin, Stefan, Bylund, Johan, Moses, Sara, Bethell, Richard, Kavanagh, Simon, Maclean, Neil, Gronda, Marcela, Wang, Xiaoming, Hurren, Rose, Minden, Mark D, Targett-Adams, Paul, Schimmer, Aaron D, Albertella, Mark

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The thymidine dideoxynucleoside analog, alovudine, inhibits the mitochondrial DNA polymerase γ, impairs oxidative phosphorylation and promotes monocytic differentiation in acute my... von Yehudai, Dana, Liyanage, Sanduni U, Hurren, Rose, Rizoska, Biljana, Albertella, Mark, Gronda, Marcela, Jeyaraju, Danny V, Wang, Xiaoming, Barghout, Samir H, MacLean, Neil, Siriwardena, Thirushi P, Jitkova, Yulia, Targett-Adams, Paul, Schimmer, Aaron D

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The PARP1 Inhibitor AZD5305 Impairs Ovarian Adenocarcinoma Progression and Visceral Metastases in Patient-derived Xenografts Alone and in Combination with Carboplatin von Dellavedova, Giulia, Decio, Alessandra, Formenti, Laura, Albertella, Mark R, Wilson, Joanne, Staniszewska, Anna D, Leo, Elisabetta, Giavazzi, Raffaella, Ghilardi, Carmen, Bani, Maria Rosa

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Hypoxia-Selective Targeting by the Bioreductive Prodrug AQ4N in Patients with Solid Tumors: Results of a Phase I Study von ALBERTELLA, Mark R, LOADMAN, Paul M, HARRIS, Peter A, WONG, Alvin, LALANI, Alshad S, TWELVES, Chris J, JONES, Philip H, PHILLIPS, Roger M, RAMPLING, Roy, BURNET, Neil, ALCOCK, Chris, ANTHONEY, Alan, VJATERS, Egils, DUNK, Chris R

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Novel 6-aminofuro[3,2-c]pyridines as potent, orally efficacious inhibitors of cMET and RON kinases von Steinig, Arno G., Li, An-Hu, Wang, Jing, Chen, Xin, Dong, Hanqing, Ferraro, Caterina, Jin, Meizhong, Kadalbajoo, Mridula, Kleinberg, Andrew, Stolz, Kathryn M., Tavares-Greco, Paula A., Wang, Ti, Albertella, Mark R., Peng, Yue, Crew, Linda, Kahler, Jennifer, Kan, Julie, Schulz, Ryan, Cooke, Andy, Bittner, Mark, Turton, Roy W., Franklin, Maryland, Gokhale, Prafulla, Landfair, Darla, Mantis, Christine, Workman, Jen, Wild, Robert, Pachter, Jonathan, Epstein, David, Mulvihill, Mark J.

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In vivo activation of the hypoxia-targeted cytotoxin AQ4N in human tumor xenografts von Williams, Kaye J, Albertella, Mark R, Fitzpatrick, Brian, Loadman, Paul M, Shnyder, Steven D, Chinje, Edwin C, Telfer, Brian A, Dunk, Chris R, Harris, Peter A, Stratford, Ian J

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Selective Tumor Targeting by the Hypoxia-Activated Prodrug AQ4N Blocks Tumor Growth and Metastasis in Preclinical Models of Pancreatic Cancer von LALANI, Alshad S, ALTERS, Susan E, WONG, Alvin, ALBERTELLA, Mark R, CLELAND, Jeffrey L, HENNER, William David

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Small-molecule inhibition of METTL3 as a strategy against myeloid leukaemia von Yankova, Eliza, Blackaby, Wesley, Albertella, Mark, Rak, Justyna, De Braekeleer, Etienne, Tsagkogeorga, Georgia, Pilka, Ewa S., Aspris, Demetrios, Leggate, Dan, Hendrick, Alan G., Webster, Natalie A., Andrews, Byron, Fosbeary, Richard, Guest, Patrick, Irigoyen, Nerea, Eleftheriou, Maria, Gozdecka, Malgorzata, Dias, Joao M. L., Bannister, Andrew J., Vick, Binje, Jeremias, Irmela, Vassiliou, George S., Rausch, Oliver, Tzelepis, Konstantinos, Kouzarides, Tony

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Aneuploid colon cancer cells have a robust spindle checkpoint von Tighe, Anthony, Johnson, Victoria L, Albertella, Mark, Taylor, Stephen S

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Abstract C056: MIV-818 stimulates an antitumor immune response in vitro and enhances the effects of pembrolizumab von Oberg, Fredrik G, Tunblad, Karin, Slipicevic, Ana, Bethell, Richard, Albertella, Mark R

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ASCERTAIN: An open-label, randomized, phase 1, window-of-opportunity study to investigate the biological effects of AZD5305 and darolutamide alone or in combination in men with pro... von Pacey, Simon, Chi, Kim N., Azad, Arun, Mehra, Niven, Dev, Harveer, Gleave, Martin, Planas, Jacques, Warren, Anne, Harrington, Elizabeth, Albertella, Mark, Squatrito, Massimo, Moore, Luiza, Zhou, TJ, Womersley, Lynsey, Sugibayashi, Ko, Cosulich, Sabina, de Paula, Bruno, Lukacs, Edit, Mateo, Joaquin

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Abstract 2930: Synergistic and additive anti-tumor effects of MIV-818 in combination with sorafenib in nonclinical hepatocellular carcinoma models von Rizoska, Biljana, Bylund, Johan, Briem, Sveinn, Kyle, Alastair, Minchinton, Andrew, Öberg, Fredrik, Göhlin, Karin, Albertella, Mark

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