Recombinant factor IX-Fc fusion protein (rFIXFc) demonstrates safety and prolonged activity in a phase 1/2a study in hemophilia B patients von Shapiro, Amy D., Ragni, Margaret V., Valentino, Leonard A., Key, Nigel S., Josephson, Neil C., Powell, Jerry S., Cheng, Gregory, Thompson, Arthur R., Goyal, Jaya, Tubridy, Karen L., Peters, Robert T., Dumont, Jennifer A., Euwart, Donald, Li, Lian, Hallén, Bengt, Gozzi, Peter, Bitonti, Alan J., Jiang, Haiyan, Luk, Alvin, Pierce, Glenn F.

Volltext

Prolonged activity of a recombinant factor VIII-Fc fusion protein in hemophilia A mice and dogs von Dumont, Jennifer A., Liu, Tongyao, Low, Susan C., Zhang, Xin, Kamphaus, George, Sakorafas, Paul, Fraley, Cara, Drager, Douglas, Reidy, Thomas, McCue, Justin, Franck, Helen W.G., Merricks, Elizabeth P., Nichols, Timothy C., Bitonti, Alan J., Pierce, Glenn F., Jiang, Haiyan

Volltext

Prolonged activity of factor IX as a monomeric Fc fusion protein von Peters, Robert T., Low, Susan C., Kamphaus, George D., Dumont, Jennifer A., Amari, John V., Lu, Qi, Zarbis-Papastoitsis, Greg, Reidy, Thomas J., Merricks, Elizabeth P., Nichols, Timothy C., Bitonti, Alan J.

Volltext

Pulmonary Delivery of an Erythropoietin Fc Fusion Protein in Non-Human Primates through an Immunoglobulin Transport Pathway von Bitonti, Alan J., Dumont, Jennifer A., Low, Susan C., Peters, Robert T., Kropp, Keith E., Palombella, Vito J., Stattel, James M., Lu, Yichun, Tan, Cristina A., Song, Jeffrey J., Garcia, Ana Maria, Simister, Neil E., Spiekermann, Gerburg M., Lencer, Wayne I., Blumberg, Richard S., Bjorkman, Pamela J.

Volltext

Reduction of IgG in Nonhuman Primates by a Peptide Antagonist of the Neonatal Fc Receptor FcRn von Mezo, Adam R., McDonnell, Kevin A., Hehir, Cristina A. Tan, Low, Susan C., Palombella, Vito J., Stattel, James M., Kamphaus, George D., Fraley, Cara, Zhang, Yixia, Dumont, Jennifer A., Bitonti, Alan J.

Volltext

Recombinant Factor IX Fc Fusion Protein Maintains Full Procoagulant Properties and Exhibits Prolonged Efficacy in Hemophilia B Mice von Toby, Garabet G, Liu, Tongyao, Buyue, Yang, Zhang, Xin, Bitonti, Alan J, Pierce, Glenn F, Sommer, Jurg M, Jiang, Haiyan, Peters, Robert T

Volltext

Fully human monoclonal antibody inhibitors of the neonatal fc receptor reduce circulating IgG in non-human primates von Nixon, Andrew E, Chen, Jie, Sexton, Daniel J, Muruganandam, Arumugam, Bitonti, Alan J, Dumont, Jennifer, Viswanathan, Malini, Martik, Diana, Wassaf, Dina, Mezo, Adam, Wood, Clive R, Biedenkapp, Joseph C, TenHoor, Chris

Volltext

Pulmonary administration of therapeutic proteins using an immunoglobulin transport pathway von Bitonti, Alan J., Dumont, Jennifer A.

Volltext

Fully human monoclonal antibody inhibitors of the neonatal Fc receptor (FcRn) reduce circulating IgG in nonhuman primates von Andrew E Nixon, Jie eChen, Daniel J Sexton, Arumugam eMuruganandam, Alan J Bitonti, Jennifer eDumont, Malini eViswanathan, Diana eMartik, Dina eWassaf, Adam eMezo, Clive R Wood, Joseph C Biedenkapp, Christopher eTenHoor

Volltext

Monomeric Fc fusions: impact on pharmacokinetic and biological activity of protein therapeutics von Dumont, Jennifer A, Low, Susan C, Peters, Robert T, Bitonti, Alan J

Volltext

Atrial Natriuretic Peptide-Fc, ANP-Fc, Fusion Proteins: Semisynthesis, In Vitro Activity and Pharmacokinetics in Rats von Mezo, Adam R, McDonnell, Kevin A, Low, Susan C, Song, Jeff, Reidy, Tom J, Lu, Qi, Amari, John V, Hoehn, Todd, Peters, Robert T, Dumont, Jennifer, Bitonti, Alan J

Volltext

Delivery of an erythropoietin-Fc fusion protein by inhalation in humans through an immunoglobulin transport pathway von DUMONT, Jennifer A, BITONTI, Alan J, CLARK, Darren, EVANS, Sean, PICKFORD, Matthew, NEWMAN, Stephen P

Volltext

Crystal Structure of Human Cyclin-Dependent Kinase 2 in Complex with the Adenine-Derived Inhibitor H717 von Dreyer, Matthias K, Borcherding, David R, Dumont, Jennifer A, Peet, Norton P, Tsay, Joseph T, Wright, Paul S, Bitonti, Alan J, Shen, Jian, Kim, Sung-Hou

Volltext

Assaying ornithine and arginine decarboxylases in some plant species von Birecka, H, Bitonti, A.J, McCann, P.P

Volltext

Reversal of Chloroquine Resistance in Malaria Parasite Plasmodium falciparum by Desipramine von Bitonti, Alan J., Sjoerdsma, Albert, McCann, Peter P., Kyle, Dennis E., Oduola, A. M. J., Rossan, Richard N., Milhous, Wilbur K., Davidson, David E.

Volltext

Inhibition of experimental metastasis and cell adhesion of B16F1 melanoma cells by inhibitors of protein kinase C von DUMONT, J. A, JONES, W. D, BITONTI, A. J

Volltext

In vitro and in vivo inhibition of glioblastoma and neuroblastoma with MDL101731, a novel ribonucleoside diphosphate reductase inhibitor von PIEPMEIER, J. M, RABIDOU, N, SCHOLD, S. C, BITONTI, A. J, PRAKASH, N. J, BUSH, T. L

Volltext

Regression of human breast tumor xenografts in response to (E)-2'-deoxy-2'-(fluoromethylene)cytidine, an inhibitor of ribonucleoside diphosphate reductase von BITONTI, A. J, DUMONT, J. A, BUSH, T. L, CASHMAN, E. A, CROSS-DOERSEN, D. E, WRIGHT, P. S, MATTHEWS, D. P, MCCARTHY, J. R, KAPLAN, D. A

Volltext

Pulmonary administration of therapeutic proteins using an immunoglobulin transport pathway: Challenges and innovations in effective pulmonary systemic and macromolecular drug deliv... von BITONTI, Alan J, DUMONT, Jennifer A

Volltext

Recombinant Factor IX Fc Fusion Protein Maintains Full Procoagulant Properties and Exhibits Prolonged Efficacy in Hemophilia B Mice: e0148255 von Toby, Garabet G, Liu, Tongyao, Buyue, Yang, Zhang, Xin, Bitonti, Alan J, Pierce, Glenn F, Sommer, Jurg M, Jiang, Haiyan, Peters, Robert T

Volltext