Anti-HER2 scFv-Directed Extracellular Vesicle-Mediated mRNA-Based Gene Delivery Inhibits Growth of HER2-Positive Human Breast Tumor Xenografts by Prodrug Activation von Wang, Jing-Hung, Forterre, Alexis V, Zhao, Jinjing, Frimannsson, Daniel O, Delcayre, Alain, Antes, Travis J, Efron, Bradley, Jeffrey, Stefanie S, Pegram, Mark D, Matin, A C

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Extracellular Vesicle-Mediated In Vitro Transcribed mRNA Delivery for Treatment of HER2 + Breast Cancer Xenografts in Mice by Prodrug CB1954 without General Toxicity von Forterre, Alexis V, Wang, Jing-Hung, Delcayre, Alain, Kim, Kyuri, Green, Carol, Pegram, Mark D, Jeffrey, Stefanie S, Matin, A C

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Exosome Targeting of Tumor Antigens Expressed by Cancer Vaccines Can Improve Antigen Immunogenicity and Therapeutic Efficacy von ROUNTREE, Ryan B, MANDL, Stefanie J, DELCAYRE, Alain, NACHTWEY, James M, DALPOZZO, Katie, DO, Lisa, LOMBARDO, John R, SCHOONMAKER, Peter L, BRINKMANN, Kay, DIRMEIER, Ulrike, LAUS, Reiner

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A phase I study of dexosome immunotherapy in patients with advanced non-small cell lung cancer von Morse, Michael A, Garst, Jennifer, Osada, Takuya, Khan, Shubi, Hobeika, Amy, Clay, Timothy M, Valente, Nancy, Shreeniwas, Revati, Sutton, Mary Ann, Delcayre, Alain, Hsu, Di-Hwei, Le Pecq, Jean-Bernard, Lyerly, H Kim

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Exosome Display technology: Applications to the development of new diagnostics and therapeutics von Delcayre, Alain, Estelles, Angeles, Sperinde, Jeffrey, Roulon, Thibaut, Paz, Pedro, Aguilar, Barbara, Villanueva, Janeth, Khine, SuSu, Le Pecq, Jean-Bernard

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Increasing vaccine potency through exosome antigen targeting von Hartman, Zachary C, Wei, Junping, Glass, Oliver K, Guo, Hongtao, Lei, Gangjun, Yang, Xiao-Yi, Osada, Takuya, Hobeika, Amy, Delcayre, Alain, Le Pecq, Jean-Bernard, Morse, Michael A, Clay, Timothy M, Lyerly, Herbert K

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Targeting Tumor Antigens to Secreted Membrane Vesicles In vivo Induces Efficient Antitumor Immune Responses von ZEELENBERG, Ingrid S, OSTROWSKI, Matias, THERY, Clotilde, KRUMEICH, Sophie, BOBRIE, Angélique, JANCIC, Carolina, BOISSONNAS, Alexandre, DELCAYRE, Alain, LE PECQ, Jean-Bernard, COMBADIERE, Behazine, AMIGORENA, Sebastian

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Lactadherin promotes VEGF-dependent neovascularization von Silvestre, Jean-Sébastien, Théry, Clotilde, Hamard, Ghislaine, Boddaert, Jacques, Aguilar, Barbara, Delcayre, Alain, Houbron, Christophe, Tamarat, Radia, Blanc-Brude, Olivier, Heeneman, Sylvia, Clergue, Michel, Duriez, Micheline, Merval, Régine, Lévy, Bernard, Tedgui, Alain, Amigorena, Sebastian, Mallat, Ziad

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Poxvirus-based active immunotherapy synergizes with CTLA-4 blockade to increase survival in a murine tumor model by improving the magnitude and quality of cytotoxic T cells von Foy, Susan P., Mandl, Stefanie J., dela Cruz, Tracy, Cote, Joseph J., Gordon, Evan J., Trent, Erica, Delcayre, Alain, Breitmeyer, James, Franzusoff, Alex, Rountree, Ryan B.

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Prospect: A randomized, double-blind, phase III efficacy trial of PROSTVAC von Bandman, Olga, Delcayre, Alain, Laus, Reiner, Godfrey, Wayne Russell, Kantoff, Philip W., Schlom, Jeffrey, Gulley, James L.

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A flow cytometry-based immuno-titration assay for rapid and accurate titer determination of modified vaccinia Ankara virus vectors von Li, Zengji, Ling, Loni, Liu, Xiaohui, Laus, Reiner, Delcayre, Alain

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Abstract A21: Active immunotherapy with PROSTVAC® demonstrates potent antitumor efficacy in a mouse model of prostate cancer von Rountree, Ryan B., Mandl, Stefanie J., Cote, Joseph, Cruz, Tracy dela, Giffon, Thierry, Gordon, Evan, Foy, Susan P., Lombardo, John R., Trent, Erica, Laus, Reiner, Delcayre, Alain

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Immunotherapy with MVA-BN®-HER2 induces HER-2-specific Th1 immunity and alters the intratumoral balance of effector and regulatory T cells von Mandl, Stefanie J., Rountree, Ryan B., Dalpozzo, Katie, Do, Lisa, Lombardo, John R., Schoonmaker, Peter L., Dirmeier, Ulrike, Steigerwald, Robin, Giffon, Thierry, Laus, Reiner, Delcayre, Alain

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Phase I dose escalation trial of MVA-BN-PRO in men with nonmetastatic castration-resistant prostate cancer von McLeod, David G., Adams, George W., Gittleman, Marc C., Bihartz, David L., Reiling, Richard B., Ruiz, Henry E., Cochran, James S., Prettyman, Julie, Delcayre, Alain, Godfrey, Wayne R., Legrand, Fatema A., Mann, Grace, Bandman, Olga

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Dendritic cell-derived exosomes in cancer immunotherapy: exploiting nature's antigen delivery pathway von Delcayre, Alain, Shu, Helen, Le Pecq, Jean-Bernard

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Elucidating immunologic mechanisms of PROSTVAC cancer immunotherapy von Mandl, Stefanie J, Rountree, Ryan B, Dela Cruz, Tracy B, Foy, Susan P, Cote, Joseph J, Gordon, Evan J, Trent, Erica, Delcayre, Alain, Franzusoff, Alex

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Immunotherapy with MVA-BN super( registered )-HER2 induces HER-2-specific Th1 immunity and alters the intratumoral balance of effector and regulatory T cells von Mandl, Stefanie J, Rountree, Ryan B, Dalpozzo, Katie, Do, Lisa, Lombardo, John R, Schoonmaker, Peter L, Dirmeier, Ulrike, Steigerwald, Robin, Giffon, Thierry, Laus, Reiner, Delcayre, Alain

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Immunotherapy with MVA-BN^sup ?^-HER2 induces HER-2-specific Th1 immunity and alters the intratumoral balance of effector and regulatory T cells von Mandl, Stefanie J, Rountree, Ryan B, Dalpozzo, Katie, Do, Lisa, Lombardo, John R, Schoonmaker, Peter L, Dirmeier, Ulrike, Steigerwald, Robin, Giffon, Thierry, Laus, Reiner, Delcayre, Alain

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Promoters for enhancing expression in poxviruses von Rountree, Ryan, Delcayre, Alain, Li, Zengji

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Exosome nanovesicles displaying G protein-coupled receptors for drug discovery von Estelles, Angeles, Sperinde, Jeff, Roulon, Thibaut, Aguilar, Barbara, Bonner, Caroline, LePecq, Jean-Bernard, Delcayre, Alain

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