Pan-NS3 protease inhibitors of hepatitis C virus based on an R3-elongated pyrazinone scaffold von Belfrage, Anna Karin, Abdurakhmanov, Eldar, Åkerblom, Eva, Brandt, Peter, Alogheli, Hiba, Neyts, Johan, Danielson, U. Helena, Sandström, Anja

Volltext

Efficient and Selective Palladium-Catalysed C-3 Urea Couplings to 3,5-Dichloro-2(1H)-pyrazinones von Belfrage, Anna Karin, Gising, Johan, Svensson, Fredrik, Åkerblom, Eva, Sköld, Christian, Sandström, Anja

Volltext

Novel Peptidomimetic Hepatitis C Virus NS3/4A Protease Inhibitors Spanning the P2–P1′ Region von Lampa, Anna K, Bergman, Sara M, Gustafsson, Sofia S, Alogheli, Hiba, Åkerblom, Eva B, Lindeberg, Gunnar G, Svensson, Richard M, Artursson, Per, Danielson, U. Helena, Karlén, Anders, Sandström, Anja

Volltext

Achiral Pyrazinone-Based Inhibitors of the Hepatitis C Virus NS3 Protease and Drug-Resistant Variants with Elongated Substituents Directed Toward the S2 Pocket von Gising, Johan, Belfrage, Anna Karin, Alogheli, Hiba, Ehrenberg, Angelica, Åkerblom, Eva, Svensson, Richard, Artursson, Per, Karlén, Anders, Danielson, U. Helena, Larhed, Mats, Sandström, Anja

Volltext

Discovery of pyrazinone based compounds that potently inhibit the drug-resistant enzyme variant R155K of the hepatitis C virus NS3 protease von Belfrage, Anna Karin, Abdurakhmanov, Eldar, Åkerblom, Eva, Brandt, Peter, Oshalim, Anna, Gising, Johan, Skogh, Anna, Neyts, Johan, Danielson, U. Helena, Sandström, Anja

Volltext

Vinylated linear P2 pyrimidinyloxyphenylglycine based inhibitors of the HCV NS3/4A protease and corresponding macrocycles von Lampa, Anna, Alogheli, Hiba, Ehrenberg, Angelica E., Åkerblom, Eva, Svensson, Richard, Artursson, Per, Danielson, U. Helena, Karlén, Anders, Sandström, Anja

Volltext

Acyl sulfonamides as potent protease inhibitors of the hepatitis C virus full-Length NS3 (Protease-Helicase/NTPase): A comparative study of different C-terminals von Johansson, Anja, Poliakov, Anton, Åkerblom, Eva, Wiklund, Karin, Lindeberg, Gunnar, Winiwarter, Susanne, Danielson, U.Helena, Samuelsson, Bertil, Hallberg, Anders

Volltext

Mechanistic studies of electrophilic protease inhibitors of full length hepatic C virus (HCV) NS3 von Poliakov, Anton, Sandström, Anja, kerblom, Eva, Helena Danielson, U.

Volltext

Evaluation of a diverse set of potential P 1 carboxylic acid bioisosteres in hepatitis C virus NS3 protease inhibitors von Rönn, Robert, Gossas, Thomas, Sabnis, Yogesh A., Daoud, Hanna, Åkerblom, Eva, Danielson, U. Helena, Sandström, Anja

Volltext

Effects on protease inhibition by modifying of helicase residues in hepatitis C virus nonstructural protein 3 von Dahl, Göran, Sandström, Anja, Åkerblom, Eva, Danielson, U. Helena

Volltext

Evaluation of a diverse set of potential P1 carboxylic acid bioisosteres in hepatitis C virus NS3 protease inhibitors von RÖNN, Robert, GOSSAS, Thomas, SABNIS, Yogesh A, DAOUD, Hanna, AKERBLOM, Eva, DANIELSON, U. Helena, SANDSTRÖM, Anja

Volltext

P2–P1′ macrocyclization of P2 phenylglycine based HCV NS3 protease inhibitors using ring-closing metathesis von Lampa, Anna, Ehrenberg, Angelica E., Vema, Aparna, Åkerblom, Eva, Lindeberg, Gunnar, Helena Danielson, U., Karlén, Anders, Sandström, Anja

Volltext

Improved P2 phenylglycine-based hepatitis C virus NS3 protease inhibitors with alkenylic prime-side substituents von Lampa, Anna, Ehrenberg, Angelica E., Gustafsson, Sofia S., Vema, Aparna, Åkerblom, Eva, Lindeberg, Gunnar, Karlén, Anders, Danielson, U. Helena, Sandström, Anja

Volltext

Phenylglycine as a novel P2 scaffold in hepatitis C virus NS3 protease inhibitors von Örtqvist, Pernilla, Peterson, Shane D., Åkerblom, Eva, Gossas, Thomas, Sabnis, Yogesh A., Fransson, Rebecca, Lindeberg, Gunnar, Helena Danielson, U., Karlén, Anders, Sandström, Anja

Volltext

Exploration of acyl sulfonamides as carboxylic acid replacements in protease inhibitors of the hepatitis C virus full-length NS3 von Rönn, Robert, Sabnis, Yogesh A., Gossas, Thomas, Åkerblom, Eva, Helena Danielson, U., Hallberg, Anders, Johansson, Anja

Volltext

Hepatitis C virus NS3 protease inhibitors comprising a novel aromatic P1 moiety von RÖNN, Robert, LAMPA, Anna, PETERSON, Shane D, GOSSAS, Thomas, AKERBLOM, Eva, DANIELSON, U. Helena, KARLEN, Anders, SANDSTRÖM, Anja

Volltext

Hepatitis C virus NS3 protease inhibitors comprising a novel aromatic P 1 moiety von Rönn, Robert, Lampa, Anna, Peterson, Shane D., Gossas, Thomas, Åkerblom, Eva, Danielson, U. Helena, Karlén, Anders, Sandström, Anja

Volltext

Structure-activity relationships of HCV NS3 protease inhibitors evaluated on the drug-resistant variants A156T and D168V von ÖRTQVIST, Pernilla, VEMA, Aparna, EHRENBERG, Angelica E, DAHL, Göran, RÖNN, Robert, AKERBLOM, Eva, KARLEN, Anders, DANIELSON, U. Helena, SANDSTRÖM, Anja

Volltext

Resistance profiling of hepatitis C virus protease inhibitors using full-length NS3 von DAHL, Göran, SANDSTRÖM, Anja, AKERBLOM, Eva, DANIELSON, U. Helena

Volltext

Tetrapeptides as potent protease inhibitors of hepatitis C virus full-Length NS3 (Protease-Helicase/NTPase) von Johansson, Anja, Poliakov, Anton, Åkerblom, Eva, Lindeberg, Gunnar, Winiwarter, Susanne, Samuelsson, Bertil, Danielson, U.Helena, Hallberg, Anders

Volltext