A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging von Zhang, Weiqi, Li, Jingyi, Suzuki, Keiichiro, Qu, Jing, Wang, Ping, Zhou, Junzhi, Liu, Xiaomeng, Ren, Ruotong, Xu, Xiuling, Ocampo, Alejandro, Yuan, Tingting, Yang, Jiping, Li, Ying, Shi, Liang, Guan, Dee, Pan, Huize, Duan, Shunlei, Ding, Zhichao, Li, Mo, Yi, Fei, Bai, Ruijun, Wang, Yayu, Chen, Chang, Yang, Fuquan, Li, Xiaoyu, Wang, Zimei, Aizawa, Emi, Goebl, April, Soligalla, Rupa Devi, Reddy, Pradeep, Esteban, Concepcion Rodriguez, Tang, Fuchou, Liu, Guang-Hui, Belmonte, Juan Carlos Izpisua

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Cryo-sensitive aggregation triggers NLRP3 inflammasome assembly in cryopyrin-associated periodic syndrome von Karasawa, Tadayoshi, Komada, Takanori, Yamada, Naoya, Aizawa, Emi, Mizushina, Yoshiko, Watanabe, Sachiko, Baatarjav, Chintogtokh, Matsumura, Takayoshi, Takahashi, Masafumi

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NLRP3 Inflammasome Activation in Lung Vascular Endothelial Cells Contributes to Intestinal Ischemia/Reperfusion-Induced Acute Lung Injury von Ito, Homare, Kimura, Hiroaki, Karasawa, Tadayoshi, Hisata, Shu, Sadatomo, Ai, Inoue, Yoshiyuki, Yamada, Naoya, Aizawa, Emi, Hishida, Erika, Kamata, Ryo, Komada, Takanori, Watanabe, Sachiko, Kasahara, Tadashi, Suzuki, Takuji, Horie, Hisanaga, Kitayama, Joji, Sata, Naohiro, Yamaji-Kegan, Kazuyo, Takahashi, Masafumi

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Establishment of mouse model of inherited PIGO deficiency and therapeutic potential of AAV-based gene therapy von Kuwayama, Ryoko, Suzuki, Keiichiro, Nakamura, Jun, Aizawa, Emi, Yoshioka, Yoshichika, Ikawa, Masahito, Nabatame, Shin, Inoue, Ken-ichi, Shimmyo, Yoshiari, Ozono, Keiichi, Kinoshita, Taroh, Murakami, Yoshiko

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Targeted Gene Correction Minimally Impacts Whole-Genome Mutational Load in Human-Disease-Specific Induced Pluripotent Stem Cell Clones von Suzuki, Keiichiro, Yu, Chang, Qu, Jing, Li, Mo, Yao, Xiaotian, Yuan, Tingting, Goebl, April, Tang, Senwei, Ren, Ruotong, Aizawa, Emi, Zhang, Fan, Xu, Xiuling, Soligalla, Rupa Devi, Chen, Feng, Kim, Jessica, Kim, Na Young, Liao, Hsin-Kai, Benner, Chris, Esteban, Concepcion Rodriguez, Jin, Yabin, Liu, Guang-Hui, Li, Yingrui, Izpisua Belmonte, Juan Carlos

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GSDME-Dependent Incomplete Pyroptosis Permits Selective IL-1α Release under Caspase-1 Inhibition von Aizawa, Emi, Karasawa, Tadayoshi, Watanabe, Sachiko, Komada, Takanori, Kimura, Hiroaki, Kamata, Ryo, Ito, Homare, Hishida, Erika, Yamada, Naoya, Kasahara, Tadashi, Mori, Yoshiyuki, Takahashi, Masafumi

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Precise in vivo genome editing via single homology arm donor mediated intron-targeting gene integration for genetic disease correction von Suzuki, Keiichiro, Yamamoto, Mako, Hernandez-Benitez, Reyna, Li, Zhe, Wei, Christopher, Soligalla, Rupa Devi, Aizawa, Emi, Hatanaka, Fumiyuki, Kurita, Masakazu, Reddy, Pradeep, Ocampo, Alejandro, Hishida, Tomoaki, Sakurai, Masahiro, Nemeth, Amy N., Nuñez Delicado, Estrella, Campistol, Josep M., Magistretti, Pierre, Guillen, Pedro, Rodriguez Esteban, Concepcion, Gong, Jianhui, Yuan, Yilin, Gu, Ying, Liu, Guang-Hui, López-Otín, Carlos, Wu, Jun, Zhang, Kun, Izpisua Belmonte, Juan Carlos

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Role of TLR5 in inflammation and tissue damage after intestinal ischemia-reperfusion injury von Ito, Homare, Sadatomo, Ai, Inoue, Yoshiyuki, Yamada, Naoya, Aizawa, Emi, Hishida, Erika, Kamata, Ryo, Karasawa, Tadayoshi, Kimura, Hiroaki, Watanabe, Sachiko, Komada, Takanori, Horie, Hisanaga, Kitayama, Joji, Sata, Naohiro, Takahashi, Masafumi

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Crucial Role of NLRP3 Inflammasome in the Development of Peritoneal Dialysis-related Peritoneal Fibrosis von Hishida, Erika, Ito, Homare, Komada, Takanori, Karasawa, Tadayoshi, Kimura, Hiroaki, Watanabe, Sachiko, Kamata, Ryo, Aizawa, Emi, Kasahara, Tadashi, Morishita, Yoshiyuki, Akimoto, Tetsu, Nagata, Daisuke, Takahashi, Masafumi

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Oral ulceration of the left palate induced by dipeptidyl peptidase-4 inhibitor（sitagliptin）：A case report von AIZAWA, EMI, JINBU, YOSHINORI

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Highly efficient transient gene expression and gene targeting in primate embryonic stem cells with helper-dependent adenoviral vectors von Suzuki, Keiichiro, Mitsui, Kaoru, Aizawa, Emi, Hasegawa, Kouichi, Kawase, Eihachiro, Yamagishi, Toshiyuki, Shimizu, Yoshihiko, Suemori, Hirofumi, Nakatsuji, Norio, Mitani, Kohnosuke

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Efficient and Accurate Homologous Recombination in hESCs and hiPSCs Using Helper-dependent Adenoviral Vectors von Aizawa, Emi, Hirabayashi, Yuka, Iwanaga, Yuzuru, Suzuki, Keiichiro, Sakurai, Kenji, Shimoji, Miho, Aiba, Kazuhiro, Wada, Tamaki, Tooi, Norie, Kawase, Eihachiro, Suemori, Hirofumi, Nakatsuji, Norio, Mitani, Kohnosuke

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Correction of Chromosomal Mutation and Random Integration in Embryonic Stem Cells with Helper-Dependent Adenoviral Vectors von Ohbayashi, Fumi, Balamotis, Michael A., Kishimoto, Atsuhiro, Aizawa, Emi, Diaz, Arturo, Hasty, Paul, Graham, Frank L., Caskey, C. Thomas, Mitani, Kohnosuke

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Generation of Human PSC-Derived Kidney Organoids with Patterned Nephron Segments and a De Novo Vascular Network von Low, Jian Hui, Li, Pin, Chew, Elaine Guo Yan, Zhou, Bingrui, Suzuki, Keiichiro, Zhang, Tian, Lian, Michelle Mulan, Liu, Meng, Aizawa, Emi, Rodriguez Esteban, Concepcion, Yong, Kylie Su Mei, Chen, Qingfeng, Campistol, Josep M., Fang, Mingliang, Khor, Chiea Chuen, Foo, Jia Nee, Izpisua Belmonte, Juan Carlos, Xia, Yun

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Caspase-11 deficiency attenuates neutrophil recruitment into the atherosclerotic lesion in apolipoprotein E-deficient mice von Karasawa, Tadayoshi, Komada, Takanori, Baatarjav, Chintogtokh, Aizawa, Emi, Mizushina, Yoshiko, Fujimura, Kenta, Gunji, Yoshitaka, Komori, Satoko, Aizawa, Hidetoshi, Jing Tao, Cantona Billton, Matsumura, Takayoshi, Takahashi, Masafumi

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Interspecies Chimerism with Mammalian Pluripotent Stem Cells von Wu, Jun, Platero-Luengo, Aida, Sakurai, Masahiro, Sugawara, Atsushi, Gil, Maria Antonia, Yamauchi, Takayoshi, Suzuki, Keiichiro, Bogliotti, Yanina Soledad, Cuello, Cristina, Morales Valencia, Mariana, Okumura, Daiji, Luo, Jingping, Vilariño, Marcela, Parrilla, Inmaculada, Soto, Delia Alba, Martinez, Cristina A., Hishida, Tomoaki, Sánchez-Bautista, Sonia, Martinez-Martinez, M. Llanos, Wang, Huili, Nohalez, Alicia, Aizawa, Emi, Martinez-Redondo, Paloma, Ocampo, Alejandro, Reddy, Pradeep, Roca, Jordi, Maga, Elizabeth A., Esteban, Concepcion Rodriguez, Berggren, W. Travis, Nuñez Delicado, Estrella, Lajara, Jeronimo, Guillen, Isabel, Guillen, Pedro, Campistol, Josep M., Martinez, Emilio A., Ross, Pablo Juan, Izpisua Belmonte, Juan Carlos

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An alternative pluripotent state confers interspecies chimaeric competency von Wu, Jun, Okamura, Daiji, Li, Mo, Suzuki, Keiichiro, Luo, Chongyuan, Ma, Li, He, Yupeng, Li, Zhongwei, Benner, Chris, Tamura, Isao, Krause, Marie N., Nery, Joseph R., Du, Tingting, Zhang, Zhuzhu, Hishida, Tomoaki, Takahashi, Yuta, Aizawa, Emi, Kim, Na Young, Lajara, Jeronimo, Guillen, Pedro, Campistol, Josep M., Esteban, Concepcion Rodriguez, Ross, Pablo J., Saghatelian, Alan, Ren, Bing, Ecker, Joseph R., Belmonte, Juan Carlos Izpisua

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Optimization of an adeno-associated viral vector for epidermal keratinocytes in vitro and in vivo von Shen, Qi, Suga, Shogo, Moriwaki, Yuta, Du, Zening, Aizawa, Emi, Okazaki, Mutsumi, Izpisua Belmonte, Juan Carlos, Hirabayashi, Yusuke, Suzuki, Keiichiro, Kurita, Masakazu

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Ortho-Selective Direct Cross-Coupling Reaction of 2-Aryloxazolines and 2-Arylimidazolines with Aryl and Alkenyl Halides Catalyzed by Ruthenium Complexes von Oi, Shuichi, Aizawa, Emi, Ogino, Yukako, Inoue, Yoshio

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Modelling Fanconi anemia pathogenesis and therapeutics using integration-free patient-derived iPSCs von Liu, Guang-Hui, Suzuki, Keiichiro, Li, Mo, Qu, Jing, Montserrat, Nuria, Tarantino, Carolina, Gu, Ying, Yi, Fei, Xu, Xiuling, Zhang, Weiqi, Ruiz, Sergio, Plongthongkum, Nongluk, Zhang, Kun, Masuda, Shigeo, Nivet, Emmanuel, Tsunekawa, Yuji, Soligalla, Rupa Devi, Goebl, April, Aizawa, Emi, Kim, Na Young, Kim, Jessica, Dubova, Ilir, Li, Ying, Ren, Ruotong, Benner, Chris, del Sol, Antonio, Bueren, Juan, Trujillo, Juan Pablo, Surralles, Jordi, Cappelli, Enrico, Dufour, Carlo, Esteban, Concepcion Rodriguez, Belmonte, Juan Carlos Izpisua

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