Inhibition of RORγT Skews TCRα Gene Rearrangement and Limits T Cell Repertoire Diversity von Guo, Yanxia, MacIsaac, Kenzie D., Chen, Yi, Miller, Richard J., Jain, Renu, Joyce-Shaikh, Barbara, Ferguson, Heidi, Wang, I-Ming, Cristescu, Razvan, Mudgett, John, Engstrom, Laura, Piers, Kyle J., Baltus, Gretchen A., Barr, Kenneth, Zhang, Hongjun, Mehmet, Huseyin, Hegde, Laxminarayan G., Hu, Xiao, Carter, Laura L., Aicher, Thomas D., Glick, Gary, Zaller, Dennis, Hawwari, Abbas, Correll, Craig C., Jones, Dallas C., Cua, Daniel J.

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Discovery of HC-7366: An Orally Bioavailable and Efficacious GCN2 Kinase Activator von Thomson, Christopher G., Aicher, Thomas D., Cheng, Weiwei, Du, Hongwen, Dudgeon, Crissy, Li, An-Hu, Li, Baozhong, Lightcap, Eric, Luo, Diheng, Mulvihill, Mark, Pan, Pengwei, Rahemtulla, Benjamin F., Rigby, Alan C., Sherborne, Bradley, Sood, Sanjeev, Surguladze, David, Talbot, Eric P. A., Tameire, Feven, Taylor, Simon, Wang, Yi, Wojnarowicz, Paulina, Xiao, Fenfen, Ramurthy, Savithri

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Discovery of LYC-55716: A Potent, Selective, and Orally Bioavailable Retinoic Acid Receptor-Related Orphan Receptor‑γ (RORγ) Agonist for Use in Treating Cancer von Aicher, Thomas D, Van Huis, Chad A, Hurd, Alexander R, Skalitzky, Donald J, Taylor, Clarke B, Beleh, Omar M, Glick, Gary, Toogood, Peter L, Yang, Bing, Zheng, Tao, Huo, Changxin, Gao, Jie, Qiao, Chenxi, Tian, Xiaolong, Zhang, Junping, Demock, Kellie, Hao, Ling-Yang, Lesch, Charles A, Morgan, Rodney W, Moisan, Jacques, Wang, Yahong, Scatina, JoAnn, Paulos, Chrystal M, Zou, Weiping, Carter, Laura L, Hu, Xiao

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Synthetic RORγ agonists regulate multiple pathways to enhance antitumor immunity von Hu, Xiao, Liu, Xikui, Moisan, Jacques, Wang, Yahong, Lesch, Charles A., Spooner, Chauncey, Morgan, Rodney W., Zawidzka, Elizabeth M., Mertz, David, Bousley, Dick, Majchrzak, Kinga, Kryczek, Ilona, Taylor, Clarke, Van Huis, Chad, Skalitzky, Don, Hurd, Alexander, Aicher, Thomas D., Toogood, Peter L., Glick, Gary D., Paulos, Chrystal M., Zou, Weiping, Carter, Laura L.

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RORγt inhibitors suppress T(H)17 responses in inflammatory arthritis and inflammatory bowel disease von de Wit, Jelle, Al-Mossawi, M Hussein, Hühn, Michael H, Arancibia-Cárcamo, Carolina V, Doig, Karen, Kendrick, Benjamin, Gundle, Roger, Taylor, Peter, Mcclanahan, Terri, Murphy, Erin, Zhang, Hongjun, Barr, Ken, Miller, J Richard, Hu, Xiao, Aicher, Thomas D, Morgan, Rodney W, Glick, Gary D, Zaller, Dennis, Correll, Craig, Powrie, Fiona, Bowness, Paul

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Discovery and preclinical development of AR453588 as an anti-diabetic glucokinase activator von Hinklin, Ronald J., Baer, Brian R., Boyd, Steven A., Chicarelli, Mark D., Condroski, Kevin R., DeWolf, Walter E., Fischer, John, Frank, Michele, Hingorani, Gary P., Lee, Patrice A., Neitzel, Nickolas A., Pratt, Scott A., Singh, Ajay, Sullivan, Francis X., Turner, Timothy, Voegtli, Walter C., Wallace, Eli M., Williams, Lance, Aicher, Thomas D.

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Identification of a New Class of Glucokinase Activators through Structure-Based Design von Hinklin, Ronald J, Boyd, Steven A, Chicarelli, Mark J, Condroski, Kevin R, DeWolf, Walter E, Lee, Patrice A, Lee, Waiman, Singh, Ajay, Thomas, Laurie, Voegtli, Walter C, Williams, Lance, Aicher, Thomas D

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Discovery of 2‑Pyridylureas as Glucokinase Activators von Hinklin, Ronald J, Aicher, Thomas D, Anderson, Deborah A, Baer, Brian R, Boyd, Steven A, Condroski, Kevin R, DeWolf, Walter E, Kraser, Christopher F, McVean, Maralee, Rhodes, Susan P, Sturgis, Hillary L, Voegtli, Walter C, Williams, Lance, Houze, Jonathan B

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Total synthesis of halichondrin B and norhalichondrin B von Aicher, Thomas D, Buszek, Keith R, Fang, Francis G, Forsyth, Craig J, Jung, Sun Ho, Kishi, Yoshito, Matelich, Michael C, Scola, Paul M, Spero, Denice M, Yoon, Suk Kyoon

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Discovery of dual positive allosteric modulators (PAMs) of the metabotropic glutamate 2 receptor and CysLT1 antagonists for treating migraine headache von Blanco, Maria-Jesus, Benesh, Dana R., Knobelsdorf, James A., Khilevich, Albert, Cortez, Guillermo S., Mokube, Fese, Aicher, Thomas D., Groendyke, Todd M., Marmsater, Fredrik P., Tang, Tony P., Johnson, Kirk W., Clemens-Smith, Amy, Muhlhauser, Mark A., Swanson, Steven, Catlow, John, Emkey, Renee, Johnson, Michael P., Schkeryantz, Jeffrey M.

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A novel coenzyme A:diacylglycerol acyltransferase 1 inhibitor stimulates lipid metabolism in muscle and lowers weight in animal models of obesity von Yamamoto, Toshihiro, Yamaguchi, Hiroshi, Miki, Hiroshi, Kitamura, Shuji, Nakada, Yoshihisa, Aicher, Thomas D., Pratt, Scott A., Kato, Koki

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Novel Series of Potent Glucokinase Activators Leading to the Discovery of AM-2394 von Dransfield, Paul J, Pattaropong, Vatee, Lai, Sujen, Fu, Zice, Kohn, Todd J, Du, Xiaohui, Cheng, Alan, Xiong, Yumei, Komorowski, Renee, Jin, Lixia, Conn, Marion, Tien, Eric, DeWolf, Walter E, Hinklin, Ronald J, Aicher, Thomas D, Kraser, Christopher F, Boyd, Steven A, Voegtli, Walter C, Condroski, Kevin R, Veniant-Ellison, Murielle, Medina, Julio C, Houze, Jonathan, Coward, Peter

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Novel acyl coenzyme A (CoA): Diacylglycerol acyltransferase-1 inhibitors: Synthesis and biological activities of diacylethylenediamine derivatives von Nakada, Yoshihisa, Aicher, Thomas D., Huerou, Yvan Le, Turner, Timothy, Pratt, Scott A., Gonzales, Stephen S., Boyd, Steve A., Miki, Hiroshi, Yamamoto, Toshihiro, Yamaguchi, Hiroshi, Kato, Koki, Kitamura, Shuji

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C5-Alkyl-2-methylurea-Substituted Pyridines as a New Class of Glucokinase Activators von Du, Xiaohui, Hinklin, Ronald J, Xiong, Yumei, Dransfield, Paul, Park, Jaehyeon, Kohn, Todd J, Pattaropong, Vatee, Lai, SuJen, Fu, Zice, Jiao, Xianyun, Chow, David, Jin, Lixia, Davda, Jasmine, Veniant, Murielle M, Anderson, Deborah A, Baer, Brian R, Bencsik, Josef R, Boyd, Steven A, Chicarelli, Mark Joseph, Mohr, Peter J, Wang, Bin, Condroski, Kevin R, DeWolf, Walter E, Conn, Marion, Tran, Thanhvien, Yang, Jerry, Aicher, Thomas D, Medina, Julio C, Coward, Peter, Houze, Jonathan B

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Non-charged thiamine analogs as inhibitors of enzyme transketolase von Thomas, Allen A., De Meese, J., Le Huerou, Y., Boyd, Steven A., Romoff, Todd T., Gonzales, Steven S., Gunawardana, Indrani, Kaplan, Tomas, Sullivan, Francis, Condroski, Kevin, Lyssikatos, Joseph P., Aicher, Thomas D., Ballard, Josh, Bernat, Bryan, DeWolf, Walter, Han, May, Lemieux, Christine, Smith, Darin, Weiler, Solly, Wright, S. Kirk, Vigers, Guy, Brandhuber, Barb

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Perhydroquinolylbenzamides as Novel Inhibitors of 11β-Hydroxysteroid Dehydrogenase Type 1 von Coppola, Gary M, Kukkola, Paivi J, Stanton, James L, Neubert, Alan D, Marcopulos, Nicholas, Bilci, Natalie A, Wang, Hua, Tomaselli, Hollis C, Tan, Jenny, Aicher, Thomas D, Knorr, Douglas C, Jeng, Arco Y, Dardik, Beatriz, Chatelain, Ricardo E

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Secondary Amides of (R)-3,3,3-Trifluoro-2-hydroxy-2-methylpropionic Acid as Inhibitors of Pyruvate Dehydrogenase Kinase von Aicher, Thomas D, Anderson, Robert C, Gao, Jiaping, Shetty, Suraj S, Coppola, Gary M, Stanton, James L, Knorr, Douglas C, Sperbeck, Donald M, Brand, Leonard J, Vinluan, Christine C, Kaplan, Emma L, Dragland, Carol J, Tomaselli, Hollis C, Islam, Amin, Lozito, Robert J, Liu, Xilin, Maniara, Wieslawa M, Fillers, William S, DelGrande, Dominick, Walter, R. Eric, Mann, William R

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RORγt inhibitors suppress TH17 responses in inflammatory arthritis and inflammatory bowel disease von de Wit, Jelle, Al-Mossawi, M. Hussein, Hühn, Michael H., Arancibia-Cárcamo, Carolina V., Doig, Karen, Kendrick, Benjamin, Gundle, Roger, Taylor, Peter, Mcclanahan, Terri, Murphy, Erin, Zhang, Hongjun, Barr, Ken, Miller, J. Richard, Hu, Xiao, Aicher, Thomas D., Morgan, Rodney W., Glick, Gary D., Zaller, Dennis, Correll, Craig, Powrie, Fiona, Bowness, Paul

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Substituted Tetrahydropyrrolo[2,1-b]oxazol-5(6H)-ones and Tetrahydropyrrolo[2,1-b]thiazol-5(6H)-ones as Hypoglycemic Agents von Aicher, Thomas D, Balkan, Bork, Bell, Philip A, Brand, Leonard J, Cheon, S. H, Deems, Rhonda O, Fell, Jay B, Fillers, William S, Fraser, James D, Gao, Jiaping, Knorr, Douglas C, Kahle, Gerald G, Leone, Christina L, Nadelson, Jeffrey, Simpson, Ronald, Smith, Howard C

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Anilides of (R)-Trifluoro-2-hydroxy-2-methylpropionic Acid as Inhibitors of Pyruvate Dehydrogenase Kinase von Bebernitz, Gregory R, Aicher, Thomas D, Stanton, James L, Gao, Jiaping, Shetty, Suraj S, Knorr, Douglas C, Strohschein, Robert J, Tan, Jennifer, Brand, Leonard J, Liu, Charles, Wang, Wei H, Vinluan, Christine C, Kaplan, Emma L, Dragland, Carol J, DelGrande, Dominick, Islam, Amin, Lozito, Robert J, Liu, Xilin, Maniara, Wieslawa M, Mann, William R

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