Oncogenic NRG1 Fusions: A New Hope for Targeted Therapy in Pancreatic Cancer von Aguirre, Andrew J

Volltext

Biomarker-Guided Development of DNA Repair Inhibitors von Cleary, James M., Aguirre, Andrew J., Shapiro, Geoffrey I., D’Andrea, Alan D.

Volltext

Translational advances in pancreatic ductal adenocarcinoma therapy von Hosein, Abdel Nasser, Dougan, Stephanie K., Aguirre, Andrew J., Maitra, Anirban

Volltext

The Human and Mouse Enteric Nervous System at Single-Cell Resolution von Drokhlyansky, Eugene, Smillie, Christopher S., Van Wittenberghe, Nicholas, Ericsson, Maria, Griffin, Gabriel K., Eraslan, Gokcen, Dionne, Danielle, Cuoco, Michael S., Goder-Reiser, Max N., Sharova, Tatyana, Kuksenko, Olena, Aguirre, Andrew J., Boland, Genevieve M., Graham, Daniel, Rozenblatt-Rosen, Orit, Xavier, Ramnik J., Regev, Aviv

Volltext

Mutational processes shape the landscape of TP53 mutations in human cancer von Giacomelli, Andrew O., Yang, Xiaoping, Lintner, Robert E., McFarland, James M., Duby, Marc, Kim, Jaegil, Howard, Thomas P., Takeda, David Y., Ly, Seav Huong, Kim, Eejung, Gannon, Hugh S., Hurhula, Brian, Sharpe, Ted, Goodale, Amy, Fritchman, Briana, Steelman, Scott, Vazquez, Francisca, Tsherniak, Aviad, Aguirre, Andrew J., Doench, John G., Piccioni, Federica, Roberts, Charles W. M., Meyerson, Matthew, Getz, Gad, Johannessen, Cory M., Root, David E., Hahn, William C.

Volltext

Refining Classification of Pancreatic Cancer Subtypes to Improve Clinical Care von Aguirre, Andrew J.

Volltext

Synthetic Lethal Vulnerabilities in KRAS -Mutant Cancers von Aguirre, Andrew J, Hahn, William C

Volltext

Atypical KRASG12R Mutant Is Impaired in PI3K Signaling and Macropinocytosis in Pancreatic Cancer von Hobbs, G. Aaron, Baker, Nicole M., Miermont, Anne M., Thurman, Ryan D., Pierobon, Mariaelena, Tran, Timothy H., Anderson, Andrew O., Waters, Andrew M., Diehl, J. Nathaniel, Papke, Bjoern, Hodge, Richard G., Klomp, Jennifer E., Goodwin, Craig M., DeLiberty, Jonathan M., Wang, Junning, Ng, Raymond W.S., Gautam, Prson, Bryant, Kirsten L., Esposito, Dominic, Campbell, Sharon L., Petricoin, Emanuel F., Simanshu, Dhirendra K., Aguirre, Andrew J., Wolpin, Brian M., Wennerberg, Krister, Rudloff, Udo, Cox, Adrienne D., Der, Channing J.

Volltext

Genomic Copy Number Dictates a Gene-Independent Cell Response to CRISPR/Cas9 Targeting von Aguirre, Andrew J, Meyers, Robin M, Weir, Barbara A, Vazquez, Francisca, Zhang, Cheng-Zhong, Ben-David, Uri, Cook, April, Ha, Gavin, Harrington, William F, Doshi, Mihir B, Kost-Alimova, Maria, Gill, Stanley, Xu, Han, Ali, Levi D, Jiang, Guozhi, Pantel, Sasha, Lee, Yenarae, Goodale, Amy, Cherniack, Andrew D, Oh, Coyin, Kryukov, Gregory, Cowley, Glenn S, Garraway, Levi A, Stegmaier, Kimberly, Roberts, Charles W, Golub, Todd R, Meyerson, Matthew, Root, David E, Tsherniak, Aviad, Hahn, William C

Volltext

ARID1B is a specific vulnerability in ARID1A-mutant cancers von Helming, Katherine C, Wang, Xiaofeng, Wilson, Boris G, Vazquez, Francisca, Haswell, Jeffrey R, Manchester, Haley E, Kim, Youngha, Kryukov, Gregory V, Ghandi, Mahmoud, Aguirre, Andrew J, Jagani, Zainab, Wang, Zhong, Garraway, Levi A, Hahn, William C, Roberts, Charles W M

Volltext

Multiplexed single-cell transcriptional response profiling to define cancer vulnerabilities and therapeutic mechanism of action von McFarland, James M., Paolella, Brenton R., Warren, Allison, Geiger-Schuller, Kathryn, Shibue, Tsukasa, Rothberg, Michael, Kuksenko, Olena, Colgan, William N., Jones, Andrew, Chambers, Emily, Dionne, Danielle, Bender, Samantha, Wolpin, Brian M., Ghandi, Mahmoud, Tirosh, Itay, Rozenblatt-Rosen, Orit, Roth, Jennifer A., Golub, Todd R., Regev, Aviv, Aguirre, Andrew J., Vazquez, Francisca, Tsherniak, Aviad

Volltext

Microenvironment drives cell state, plasticity, and drug response in pancreatic cancer von Raghavan, Srivatsan, Winter, Peter S., Navia, Andrew W., Williams, Hannah L., DenAdel, Alan, Lowder, Kristen E., Galvez-Reyes, Jennyfer, Kalekar, Radha L., Mulugeta, Nolawit, Kapner, Kevin S., Raghavan, Manisha S., Borah, Ashir A., Liu, Nuo, Väyrynen, Sara A., Costa, Andressa Dias, Ng, Raymond W.S., Wang, Junning, Hill, Emma K., Ragon, Dorisanne Y., Brais, Lauren K., Jaeger, Alex M., Spurr, Liam F., Li, Yvonne Y., Cherniack, Andrew D., Booker, Matthew A., Cohen, Elizabeth F., Tolstorukov, Michael Y., Wakiro, Isaac, Rotem, Asaf, Johnson, Bruce E., McFarland, James M., Sicinska, Ewa T., Jacks, Tyler E., Sullivan, Ryan J., Shapiro, Geoffrey I., Clancy, Thomas E., Perez, Kimberly, Rubinson, Douglas A., Ng, Kimmie, Cleary, James M., Crawford, Lorin, Manalis, Scott R., Nowak, Jonathan A., Wolpin, Brian M., Hahn, William C., Aguirre, Andrew J., Shalek, Alex K.

Volltext

Neoadjuvant Chemotherapy Is Associated with Altered Immune Cell Infiltration and an Anti-Tumorigenic Microenvironment in Resected Pancreatic Cancer von Dias Costa, Andressa, Väyrynen, Sara A, Chawla, Akhil, Zhang, Jinming, Väyrynen, Juha P, Lau, Mai Chan, Williams, Hannah L, Yuan, Chen, Morales-Oyarvide, Vicente, Elganainy, Dalia, Singh, Harshabad, Cleary, James M, Perez, Kimberly, Ng, Kimmie, Freed-Pastor, William, Mancias, Joseph D, Dougan, Stephanie K, Wang, Jiping, Rubinson, Douglas A, Dunne, Richard F, Kozak, Margaret M, Brais, Lauren, Reilly, Emma, Clancy, Thomas, Linehan, David C, Chang, Daniel T, Hezel, Aram F, Koong, Albert C, Aguirre, Andrew J, Wolpin, Brian M, Nowak, Jonathan A

Volltext

Analysis of Fusobacterium persistence and antibiotic response in colorectal cancer von Bullman, Susan, Pedamallu, Chandra S., Sicinska, Ewa, Clancy, Thomas E., Zhang, Xiaoyang, Cai, Diana, Neuberg, Donna, Huang, Katherine, Guevara, Fatima, Nelson, Timothy, Chipashvili, Otari, Hagan, Timothy, Walker, Mark, Ramachandran, Aruna, Diosdado, Begoña, Serna, Garazi, Mulet, Nuria, Landolfi, Stefania, Ramon y Cajal, Santiago, Fasani, Roberta, Aguirre, Andrew J., Ng, Kimmie, Élez, Elena, Ogino, Shuji, Tabernero, Josep, Fuchs, Charles S., Hahn, William C., Nuciforo, Paolo, Meyerson, Matthew

Volltext

Composition, Spatial Characteristics, and Prognostic Significance of Myeloid Cell Infiltration in Pancreatic Cancer von Väyrynen, Sara A, Zhang, Jinming, Yuan, Chen, Väyrynen, Juha P, Dias Costa, Andressa, Williams, Hannah, Morales-Oyarvide, Vicente, Lau, Mai Chan, Rubinson, Douglas A, Dunne, Richard F, Kozak, Margaret M, Wang, Wenjia, Agostini-Vulaj, Diana, Drage, Michael G, Brais, Lauren, Reilly, Emma, Rahma, Osama, Clancy, Thomas, Wang, Jiping, Linehan, David C, Aguirre, Andrew J, Fuchs, Charles S, Coussens, Lisa M, Chang, Daniel T, Koong, Albert C, Hezel, Aram F, Ogino, Shuji, Nowak, Jonathan A, Wolpin, Brian M

Volltext

NCOA4-Mediated Ferritinophagy Is a Pancreatic Cancer Dependency via Maintenance of Iron Bioavailability for Iron-Sulfur Cluster Proteins von Santana-Codina, Naiara, Del Rey, Maria Quiles, Kapner, Kevin S, Zhang, Huan, Gikandi, Ajami, Malcolm, Callum, Poupault, Clara, Kuljanin, Miljan, John, Kristen M, Biancur, Douglas E, Chen, Brandon, Das, Nupur K, Lowder, Kristen E, Hennessey, Connor J, Huang, Wesley, Yang, Annan, Shah, Yatrik M, Nowak, Jonathan A, Aguirre, Andrew J, Mancias, Joseph D

Volltext

Getting a handle on KRAS inhibitor resistance with hapten-mediated anti-tumor immunity von Freed-Pastor, William A., Aguirre, Andrew J.

Volltext

Single-nucleus and spatial transcriptome profiling of pancreatic cancer identifies multicellular dynamics associated with neoadjuvant treatment von Hwang, William L., Jagadeesh, Karthik A., Guo, Jimmy A., Hoffman, Hannah I., Yadollahpour, Payman, Reeves, Jason W., Mohan, Rahul, Drokhlyansky, Eugene, Van Wittenberghe, Nicholas, Ashenberg, Orr, Farhi, Samouil L., Schapiro, Denis, Divakar, Prajan, Miller, Eric, Zollinger, Daniel R., Eng, George, Schenkel, Jason M., Su, Jennifer, Shiau, Carina, Yu, Patrick, Freed-Pastor, William A., Abbondanza, Domenic, Mehta, Arnav, Gould, Joshua, Lambden, Conner, Porter, Caroline B. M., Tsankov, Alexander, Dionne, Danielle, Waldman, Julia, Cuoco, Michael S., Nguyen, Lan, Delorey, Toni, Phillips, Devan, Barth, Jaimie L., Kem, Marina, Rodrigues, Clifton, Ciprani, Debora, Roldan, Jorge, Zelga, Piotr, Jorgji, Vjola, Chen, Jonathan H., Ely, Zackery, Zhao, Daniel, Fuhrman, Kit, Fropf, Robin, Beechem, Joseph M., Loeffler, Jay S., Ryan, David P., Weekes, Colin D., Ferrone, Cristina R., Qadan, Motaz, Aryee, Martin J., Jain, Rakesh K., Neuberg, Donna S., Wo, Jennifer Y., Hong, Theodore S., Xavier, Ramnik, Aguirre, Andrew J., Rozenblatt-Rosen, Orit, Mino-Kenudson, Mari, Castillo, Carlos Fernandez-del, Liss, Andrew S., Ting, David T., Jacks, Tyler, Regev, Aviv

Volltext

Beyond the Front Line: Emerging Data for Maintenance Therapy in Pancreatic Cancer von Singh, Harshabad, Perez, Kimberly, Wolpin, Brian M, Aguirre, Andrew J

Volltext

Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway von Viswanathan, Vasanthi S., Ryan, Matthew J., Dhruv, Harshil D., Gill, Shubhroz, Eichhoff, Ossia M., Seashore-Ludlow, Brinton, Kaffenberger, Samuel D., Eaton, John K., Shimada, Kenichi, Aguirre, Andrew J., Viswanathan, Srinivas R., Chattopadhyay, Shrikanta, Tamayo, Pablo, Yang, Wan Seok, Rees, Matthew G., Chen, Sixun, Boskovic, Zarko V., Javaid, Sarah, Huang, Cherrie, Wu, Xiaoyun, Tseng, Yuen-Yi, Roider, Elisabeth M., Gao, Dong, Cleary, James M., Wolpin, Brian M., Mesirov, Jill P., Haber, Daniel A., Engelman, Jeffrey A., Boehm, Jesse S., Kotz, Joanne D., Hon, Cindy S., Chen, Yu, Hahn, William C., Levesque, Mitchell P., Doench, John G., Berens, Michael E., Shamji, Alykhan F., Clemons, Paul A., Stockwell, Brent R., Schreiber, Stuart L.

Volltext