A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development von Morgan, Ryan E, van Staden, Carlo J, Chen, Yuan, Kalyanaraman, Natarajan, Kalanzi, Jackson, Dunn, 2nd, Robert T, Afshari, Cynthia A, Hamadeh, Hisham K

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Diverse roles of the nuclear orphan receptor CAR in regulating hepatic genes in response to phenobarbital von Ueda, Akiko, Hamadeh, Hisham K, Webb, Heather K, Yamamoto, Yukio, Sueyoshi, Tatsuya, Afshari, Cynthia A, Lehmann, Jürgen M, Negishi, Masahiko

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BRCA1 Mediates Ligand-Independent Transcriptional Repression of the Estrogen Receptor von Zheng, Lei, Annab, Lois A., Afshari, Cynthia A., Lee, Wen-Hwa, Boyer, Thomas G.

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Common handling procedures conducted in preclinical safety studies result in minimal hepatic gene expression changes in Sprague-Dawley rats von He, Yudong D, Karbowski, Christine M, Werner, Jon, Everds, Nancy, Di Palma, Chris, Chen, Yuan, Higgins-Garn, Marnie, Tran, Sandra, Afshari, Cynthia A, Hamadeh, Hisham K

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Prediction of Nephrotoxicant Action and Identification of Candidate Toxicity-Related Biomarkers von Thukral, Sushil K., Nordone, Paul J., Hu, Rong, Sullivan, Leah, Galambos, Eric, Fitzpatrick, Vincent D., Healy, Laura, Bass, Michael B., Cosenza, Mary E., Afshari, Cynthia A.

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Interference with Bile Salt Export Pump Function Is a Susceptibility Factor for Human Liver Injury in Drug Development von Morgan, Ryan E., Trauner, Michael, van Staden, Carlo J., Lee, Paul H., Ramachandran, Bharath, Eschenberg, Michael, Afshari, Cynthia A., Qualls, Charles W., Lightfoot-Dunn, Ruth, Hamadeh, Hisham K.

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The evolution of bioinformatics in toxicology: advancing toxicogenomics von Afshari, Cynthia A, Hamadeh, Hisham K, Bushel, Pierre R

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Time-dependent cellular and transcriptional changes in the osteoblast lineage associated with sclerostin antibody treatment in ovariectomized rats von Taylor, Scott, Ominsky, Michael S, Hu, Rong, Pacheco, Efrain, He, Yudong D, Brown, Danielle L, Aguirre, J. Ignacio, Wronski, Thomas J, Buntich, Sabina, Afshari, Cynthia A, Pyrah, Ian, Nioi, Paul, Boyce, Rogely Waite

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Short-Chain Fatty Acids Enhance Nuclear Receptor Activity through Mitogen-Activated Protein Kinase Activation and Histone Deacetylase Inhibition von Jansen, Michelle S., Nagel, Susan C., Miranda, Phillippa J., Lobenhofer, Edward K., Afshari, Cynthia A., McDonnell, Donald P., O'Malley, Bert W.

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A novel statistical algorithm for gene expression analysis helps differentiate pregnane X receptor-dependent and independent mechanisms of toxicity von Mongan, M Ann, Dunn, Robert T, Vonderfecht, Steven, Everds, Nancy, Chen, Guang, Su, Cheng, Higgins-Garn, Marnie, Chen, Yuan, Afshari, Cynthia A, Williamson, Toni L, Carlock, Linda, Dipalma, Christopher, Moss, Suzanne, Bussiere, Jeanine, Qualls, Charles, He, Yudong D, Hamadeh, Hisham K

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Downstream E-box-mediated regulation of the human telomerase reverse transcriptase (hTERT) gene transcription: evidence for an endogenous mechanism of transcriptional repression von Horikawa, Izumi, Cable, P LouAnn, Mazur, Sharlyn J, Appella, Ettore, Afshari, Cynthia A, Barrett, J Carl

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Methapyrilene Toxicity: Anchorage of Pathologic Observations to Gene Expression Alterations von Hamadeh, Hisham K., Knight, Brian L., Haugen, Astrid C., Sieber, Stella, Amin, Rupesh P., Bushel, Pierre R., Stoll, Raymond, Blanchard, Kerry, Jayadev, Supriya, Tennant, Raymond W., Cunningham, Michael L., Afshari, Cynthia A., Paules, Richard S.

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Mot1 Activates and Represses Transcription by Direct, ATPase-Dependent Mechanisms von Dasgupta, Arindam, Darst, Russell P., Martin, Karla J., Afshari, Cynthia A., Auble, David T.

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Retinal Toxicity Induced by a Novel β-secretase Inhibitor in the Sprague-Dawley Rat von Fielden, Mark R., Werner, Jonathan, Jamison, Jeff A., Coppi, Aldo, Hickman, Dean, Dunn, Robert T., Trueblood, Esther, Zhou, Lei, Afshari, Cynthia A., Lightfoot-Dunn, Ruth

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Alterations in apoptotic signaling in human idiopathic cardiomyopathic hearts in failure von Steenbergen, Charles, Afshari, Cynthia A, Petranka, John G, Collins, Jennifer, Martin, Karla, Bennett, Lee, Haugen, Astrid, Bushel, Pierre, Murphy, Elizabeth

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Overview of the Application of Transcription Profiling Using Selected Nephrotoxicants for Toxicology Assessment von Kramer, Jeffrey A., Pettit, Syril D., Amin, Rupesh P., Bertram, Timothy A., Car, Bruce, Cunningham, Michael, Curtiss, Sandra W., Davis, John W., Kind, Clive, Lawton, Michael, Naciff, Jorge M., Oreffo, Victor, Roman, Richard J., Sistare, Frank D., Stevens, James, Thompson, Karol, Vickers, Alison E., Wild, Stacey, Afshari, Cynthia A.

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Assessment of repeated microarray experiments using mixed tissue RNA reference samples von Mongan, Ann, Higgins, Marnie A, Pine, Scott, Afshari, Cynthia A, Hamadeh, Hisham K

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Utilization of human nuclear receptors as an early counter screen for off-target activity: a case study with a compendium of 615 known drugs von Fan, Fan, Hu, Rong, Munzli, Anke, Chen, Yuan, Dunn, 2nd, Robert T, Weikl, Kerstin, Strauch, Simone, Schwandner, Ralf, Afshari, Cynthia A, Hamadeh, Hisham, Nioi, Paul

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Estrogen Receptor-Dependent Genomic Responses in the Uterus Mirror the Biphasic Physiological Response to Estrogen von Hewitt, Sylvia Curtis, Deroo, Bonnie J, Hansen, Katherine, Collins, Jennifer, Grissom, Sherry, Afshari, Cynthia A, Korach, Kenneth S

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A systematic assessment of mitochondrial function identified novel signatures for drug-induced mitochondrial disruption in cells von Li, Nianyu, Oquendo, Elisa, Capaldi, Roderick A, Robinson, J Paul, He, Yudong D, Hamadeh, Hisham K, Afshari, Cynthia A, Lightfoot-Dunn, Ruth, Narayanan, Padma Kumar

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