PF-06463922 is a potent and selective next-generation ROS1/ALK inhibitor capable of blocking crizotinib-resistant ROS1 mutations von Zou, Helen Y., Li, Qiuhua, Engstrom, Lars D., West, Melissa, Appleman, Vicky, Wong, Katy A., McTigue, Michele, Deng, Ya-Li, Liu, Wei, Brooun, Alexei, Timofeevski, Sergei, McDonnell, Scott R. P., Jiang, Ping, Falk, Matthew D., Lappin, Patrick B., Affolter, Timothy, Nichols, Tim, Hu, Wenyue, Lam, Justine, Johnson, Ted W., Smeal, Tod, Charest, Al, Fantin, Valeria R.

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Inhibition of immune checkpoints PD-1, CTLA-4, and IDO1 coordinately induces immune-mediated liver injury in mice von Affolter, Timothy, Llewellyn, Heather P, Bartlett, Derek W, Zong, Qing, Xia, Shuhua, Torti, Vince, Ji, Changhua

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Anti–IL-7 receptor-α reverses established type 1 diabetes in nonobese diabetic mice by modulating effector T-cell function von Lee, Li-Fen, Logronio, Kathryn, Tu, Guang Huan, Zhai, Wenwu, Ni, Irene, Mei, Li, Dilley, Jeanette, Yu, Jessica, Rajpal, Arvind, Brown, Colleen, Appah, Charles, Chin, Sherman Michael, Han, Bora, Affolter, Timothy, Lin, John C

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T cells and monocyte-derived myeloid cells mediate immunotherapy-related hepatitis in a mouse model von Llewellyn, Heather P., Arat, Seda, Gao, Jingjin, Wen, Ji, Xia, Shuhua, Kalabat, Dalia, Oziolor, Elias, Virgen-Slane, Richard, Affolter, Timothy, Ji, Changhua

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PF-06463922, an ALK/ROS1 Inhibitor, Overcomes Resistance to First and Second Generation ALK Inhibitors in Preclinical Models von Zou, Helen Y., Friboulet, Luc, Kodack, David P., Engstrom, Lars D., Li, Qiuhua, West, Melissa, Tang, Ruth W., Wang, Hui, Tsaparikos, Konstantinos, Wang, Jinwei, Timofeevski, Sergei, Katayama, Ryohei, Dinh, Dac M., Lam, Hieu, Lam, Justine L., Yamazaki, Shinji, Hu, Wenyue, Patel, Bhushankumar, Bezwada, Divya, Frias, Rosa L., Lifshits, Eugene, Mahmood, Sidra, Gainor, Justin F., Affolter, Timothy, Lappin, Patrick B., Gukasyan, Hovhannes, Lee, Nathan, Deng, Shibing, Jain, Rakesh K., Johnson, Ted W., Shaw, Alice T., Fantin, Valeria R., Smeal, Tod

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Abstract P065: Effects of targeted radiotherapy on tumor immune landscape in diverse murine tumor models von Wirtz, Tristan, Lee, Catherine, Xie, Tao, Manzuk, Lisa, Kraus, Manfred, Dillon, Christopher, Affolter, Timothy, Giddabasappa, Anand

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Efficacy and Imaging-Enabled Pharmacodynamic Profiling of KRAS G12C Inhibitors in Xenograft and Genetically Engineered Mouse Models of Cancer von Lee, Catherine, Jiang, Ziyue Karen, Planken, Simon, Manzuk, Lisa K, Ortiz, Roberto, Hall, Michael, Noorbehesht, Kavon, Ram, Sripad, Affolter, Timothy, Troche, Gabriel E, Ihle, Nathan T, Johnson, Theodore, Ahn, Youngwook, Kraus, Manfred, Giddabasappa, Anand

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Abstract 2960: A novel mouse model of pancreatic cancer reveals new insights into cell cycle deregulation von Adams, Christina, Wang, Lynn, Wang, Tim S., Miller, Nichol, McMillan, Elizabeth, Ramstetter, Monica, Chionis, John, Eisele, Koleen, Almaden, Jonathan, Affolter, Timothy, Pillai, Smitha, VanArsdale, Todd, Dillon, Chris, Dann, Stephen G.

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Axitinib and crizotinib combination therapy inhibits bone loss in a mouse model of castration resistant prostate cancer von Eswaraka, Jeetendra, Giddabasappa, Anand, Han, Guangzhou, Lalwani, Kush, Eisele, Koleen, Feng, Zheng, Affolter, Timothy, Christensen, James, Li, Gang

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Phenotype of TPBG Gene Replacement in the Mouse and Impact on the Pharmacokinetics of an Antibody–Drug Conjugate von Hu, George, Leal, Mauricio, Lin, Qingcong, Affolter, Timothy, Sapra, Puja, Bates, Brian, Damelin, Marc

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[18F]FLT-PET Imaging Does Not Always Light Up Proliferating Tumor Cells von ZHANG, Cathy C, ZHENGMING YAN, FAHEY, Neeta R, CULLINANE, Carleen, SPILKER, Mary, ZASADNY, Kenneth, O'BRIEN, Peter, BUCKMAN, Dana, WONG, Anthony, CHRISTENSEN, James G, WENLIN LI, KUSZPIT, Kyle, PAINTER, Cory L, QIN ZHANG, LAPPIN, Patrick B, NICHOLS, Tim, LIRA, Maruja E, AFFOLTER, Timothy

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Abstract 130: PF-06463922, a novel next generation ALK/ROS1 inhibitor, overcomes resistance to 1st and 2nd generation ALK inhibitors in pre-clinical models von Friboulet, Luc, Zou, Helen, Kodack, David P., Engstrom, Lars D., Li, Qiuhua, West, Melissa, Tang, Ruth W., Wang, Hui, Tsaparikos, Konstantinos, Wang, Jinwei, Timofeevski, Sergei, Dinh, Dac M., Lam, Hieu, Lam, Justine L., Yamazaki, Shinji, Hu, Wenyue, Patel, Bhushankumar, Bezwada, Divya, Mahmood, Sidra, Lifshits, Eugene, Affolter, Timothy, Lappin, Patrick B., Gukasyan, Hovhannes, Lee, Nathan, Deng, Shibing, Jain, Rakesh K., Johnson, Ted W., Shaw, Alice T., Fantin, Valeria R., Smeal, Tod

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PF-06463922, an ALK/ROS1 inhibitor, overcomes resistance to 1st and 2nd generation ALK inhibitors in pre-clinical models von Zou, Helen Y., Friboulet, Luc, Kodack, David P., Engstrom, Lars D., Li, Qiuhua, West, Melissa, Tang, Ruth W., Wang, Hui, Tsaparikos, Konstantinos, Wang, Jinwei, Timofeevski, Sergei, Katayama, Ryohei, Dinh, Dac M., Lam, Hieu, Lam, Justine L., Yamazaki, Shinji, Hu, Wenyue, Patel, Bhushankumar, Bezwada, Divya, Frias, Rosa L., Lifshits, Eugene, Mahmood, Sidra, Gainor, Justin F., Affolter, Timothy, Lappin, Patrick B., Gukasyan, Hovhannes, Lee, Nathan, Deng, Shibing, Jain, Rakesh K, Johnson, Ted W., Shaw, Alice T., Fantin, Valeria R., Smeal, Tod

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Correction: Anti-IL-7 receptor-α reverses established type 1 diabetes in nonobese diabetic mice by modulating effector T-cell function von Lee, Li-Fen, Logronio, Kathryn, Tu, Guang Huan, Zhai, Wenwu, Ni, Irene, Mei, Li, Dilley, Jeanette, Yu, Jessica, Rajpal, Arvind, Brown, Colleen, Appah, Charles, Chin, Sherman Michael, Han, Bora, Affolter, Timothy, Lin, John C.

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Anti-IL-7 receptor-[alpha] reverses established type 1 diabetes in nonobese diabetic mice by modulating effector T-cell function von Lee, Li-Fen, Logronio, Kathryn, Tu, Guang Huan, Zhai, Wenwu, Ni, Irene, Mei, Li, Dilley, Jeanette, Yu, Jessica, Rajpal, Arvind, Brown, Colleen, Appah, Charles, Chin, Sherman Michael, Han, Bora, Affolter, Timothy, Lin, John C

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Abstract C253: PF-06463922, a novel brain-penetrating small molecule inhibitor of ALK/ROS1 with potent activity against a broad spectrum of ALK resistant mutations in preclinical m... von Zou, Helen Y., Engstrom, Lars R., Li, Qiuhua, West Lu, Melissa, Tang, Ruth Wei, Wang, Hui, Tsaparikos, Konstantinos, Wang, Jinwei, Timofeevski, Sergei, Dinh, Dac M., Lam, Hieu, Lam, Justine, Yamazaki, Shinji, Hu, Wenyue, Affolter, Timothy, Lappin, Patrick B., Gukasyan, Hovhannes, Lee, Nathan, Tursi, Jennifer M., Johnson, Ted W., Fantin, Valeria, Smeal, Tod

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Investigation of Ocular Events Associated with Taprenepag Isopropyl, a Topical EP2 Agonist in Development for Treatment of Glaucoma von YANOCHKO, Gina M, AFFOLTER, Timothy, EIGHMY, Johnnie J, EVANS, Mark G, KHOH-REITER, Su, DONG LEE, MILLER, Paul E, SHIUE, Michael H. I, TRAJKOVIC, Dusko, JESSEN, Bart A

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Abstract 5218: γ-secretase inhibitor PF-03084014 impairs Notch signaling and induces antiangiogenic and antitumor effects in breast cancer models von Zhang, Cathy, Zhang, Qin, Painter, Cory, Yan, Zhengming, Li, Wendy, Buckman, Dana, Zheng, Xianxian, Kuszpit, Kyle, Wong, Anthony, Affolter, Timothy, Lappin, Patrick B., Lee, Nathan V., Wei, Ping, Qiu, Ming, Randolph, Sophia, Smeal, Tod, Christensen, James G.

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Mycobacterium tuberculosis Complex Infection in a Dog von Sykes, J.E, Cannon, A.B, Norris, A.J, Byrne, B.A, Affolter, T, O'Malley, M.A, Wisner, E.R

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Mycobacterium tuberculosis Complex Infection in a Dog von Sykes, Jane E., Cannon, Allison B., Norris, Aimee J., Byrne, Barbara A., Affolter, Timothy, O'Malley, Michael A., Wisner, Erik R.

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