Binding Properties of Human TLR-9 Receptor to Cobitolimod and a Candidate for Treatment of Active Ulcerative Colitis in Late Stage of Clinical Development von Zargari, Arezou, Admyre, Charlotte, Knittel, Thomas

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Mo1738 - Binding Properties of Human TLR-9 Receptor to Cobitolimod and a Candidate for Treatment of Active Ulcerative Colitis in Late Stage of Clinical Development von Zargari, Arezou, Admyre, Charlotte, Knittel, Thomas

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Exosomes with Immune Modulatory Features Are Present in Human Breast Milk von Admyre, Charlotte, Johansson, Sara M, Qazi, Khaleda Rahman, Filen, Jan-Jonas, Lahesmaa, Riitta, Norman, Mikael, Neve, Etienne P. A, Scheynius, Annika, Gabrielsson, Susanne

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Su2005 - A Retrospective Analysis of the Clinical Application of the Multigene Analysis Test Dibicol® to Differentiate Between Ulcerative Colitis, Crohns Disease and Non-IBD von Admyre, Charlotte, Knittel, Thomas, Ost, Ake, Lofberg, Robert, Zargari, Arezou

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Direct exosome stimulation of peripheral human T cells detected by ELISPOT von Admyre, Charlotte, Johansson, Sara M, Paulie, Staffan, Gabrielsson, Susanne

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Mo1739 - IL-10 Induction Properties of the TLR-9 Agonist Cobitolimod and a Candidate for Treatment of Active Ulcerative Colitis in Late Stage of Clinical Development von Admyre, Charlotte, Zargari, Arezou, Atreya, Raja, Knittel, Thomas

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IL-10 Induction Properties of the TLR-9 Agonist Cobitolimod and a Candidate for Treatment of Active Ulcerative Colitis in Late Stage of Clinical Development von Admyre, Charlotte, Zargari, Arezou, Atreya, Raja, Knittel, Thomas

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Exosomes with major histocompatibility complex class II and co-stimulatory molecules are present in human BAL fluid von Admyre, C, Grunewald, J, Thyberg, J, Gripenback, S, Tornling, G, Eklund, A, Scheynius, A, Gabrielsson, S

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B cell-derived exosomes can present allergen peptides and activate allergen-specific T cells to proliferate and produce TH2-like cytokines von ADMYRE, Charlotte, BOHLE, Barbara, JOHANSSON, Sara M, FOCKE-TEJKL, Margarete, VALENTA, Rudolf, SCHEYNIUS, Annika, GABRIELSSON, Susanne

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Clinical efficacy of the Toll-like receptor 9 agonist cobitolimod using patient-reported-outcomes defined clinical endpoints in patients with ulcerative colitis von Atreya, Raja, Reinisch, Walter, Peyrin-Biroulet, Laurent, Scaldaferri, Franco, Admyre, Charlotte, Knittel, Thomas, Kowalski, Jan, Neurath, Markus Friedrich, Hawkey, Christopher

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The TLR9 Agonist Cobitolimod Induces IL10-Producing Wound Healing Macrophages and Regulatory T Cells in Ulcerative Colitis von Schmitt, Heike, Ulmschneider, Julia, Billmeier, Ulrike, Vieth, Michael, Scarozza, Patrizio, Sonnewald, Sophia, Reid, Stephen, Atreya, Imke, Rath, Timo, Zundler, Sebastian, Langheinrich, Melanie, Schüttler, Jürgen, Hartmann, Arndt, Winkler, Thomas, Admyre, Charlotte, Knittel, Thomas, Dieterich Johansson, Christine, Zargari, Arezou, Neurath, Markus F, Atreya, Raja

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Direct exosome stimulation of peripheral humanT cells detected by ELISPOT von Admyre, Charlotte, Johansson, Sara M., Paulie, Staffan, Gabrielsson, Susanne

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Clinical Effects of a Topically Applied Toll-like Receptor 9 Agonist in Active Moderate-to-Severe Ulcerative Colitis von Atreya, Raja, Bloom, Stuart, Scaldaferri, Franco, Gerardi, Viviana, Admyre, Charlotte, Karlsson, Åsa, Knittel, Thomas, Kowalski, Jan, Lukas, Milan, Löfberg, Robert, Nancey, Stephane, Petryka, Robert, Rydzewska, Grazyna, Schnabel, Robert, Seidler, Ursula, Neurath, Markus F., Hawkey, Christopher

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Tu1765 - The TLR9 Agonist Cobitolimod Modulates the Immune System in Ulcerative Colitis Patients by Balancing the TH17/T-REG Cell Response von Schmitt, Heike, Billmeier, Ulrike, Ulmschneider, Julia L., Admyre, Charlotte, Knittel, Thomas, Zargari, Arezou, Neurath, Markus, Atreya, Raja

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Immunomodulatory oligonucleotides inhibit neutrophil migration by decreasing the surface expression of interleukin‐8 and leukotriene B 4 receptors von Admyre, Charlotte, Axelsson, Lars‐Göran, von Stein, Oliver, Zargari, Arezou

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Immunomodulatory oligonucleotides inhibit neutrophil migration by decreasing the surface expression of interleukin‐8 and leukotriene B4 receptors von Admyre, Charlotte, Axelsson, Lars‐Göran, Stein, Oliver, Zargari, Arezou

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Topical treatment with the Toll-like receptor agonist DIMS0150 has potential for lasting relief of symptoms in patients with chronic active ulcerative colitis by restoring glucocor... von Musch, Eugen, Lutfi, Tamim, von Stein, Petra, Zargari, Arezou, Admyre, Charlotte, Malek, Mouhamad, Löfberg, Robert, von Stein, Oliver D

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Tu1721 The Anti-Inflammatory Cytokine IL-10 Is an Important Mediator of the Action of the TLR-9 Agonist DIMS0150 von Admyre, Charlotte, von Stein, Petra, Knittel, Thomas, von Stein, Oliver, Zargar, Arezou

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Tu1706 The TLR-9 Agonist DIMS0150 Leads to the Induction of IL-10 Positive Mucosal Cells in Ulcerative Colitis Patients von Billmeier, Ulrike, Admyre, Charlotte, Knittel, Thomas, Zargari, Arezou, Neurath, Markus F, Atrey, Raja

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Different types of in vitro generated human monocyte-derived dendritic cells release exosomes with distinct phenotypes von Johansson, Sara M, Admyre, Charlotte, Scheynius, Annika, Gabrielsson, Susanne

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