Demonstration of a genetic therapeutic index for tumors expressing oncogenic BRAF by the kinase inhibitor SB-590885 von KING, Alastair J, PATRICK, Denis R, HUGGER, Erin, LIFU WANG, KARRETH, Florian, LOUGHEED, Julie C, LEE, Jae, CHAU, David, STOUT, Thomas J, MAY, Earl W, ROMINGER, Cynthia M, SCHABER, Michael D, BATORSKY, Roberta S, LUSONG LUO, LAKDAWALA, Ami S, ADAMS, Jerry L, CONTRACTOR, Rooja G, SMALLEY, Keiran S. M, HERLYN, Meenhard, MORRISSEY, Michael M, TUVESON, David A, HUANG, Pearl S, HO, Maureen L, DO, Hieu T, SHU YUN ZHANG, KUMAR, Rakesh, RUSNAK, David W, TAKLE, Andrew K, WILSON, David M

Volltext

GSK1070916, a potent Aurora B/C kinase inhibitor with broad antitumor activity in tissue culture cells and human tumor xenograft models von Hardwicke, Mary Ann, Oleykowski, Catherine A, Plant, Ramona, Wang, Jamin, Liao, Qiaoyin, Moss, Katherine, Newlander, Ken, Adams, Jerry L, Dhanak, Dashyant, Yang, Jingsong, Lai, Zhihong, Sutton, David, Patrick, Denis

Volltext

Structural basis of inhibitor selectivity in MAP kinases von Wang, Zhulun, Canagarajah, Bertram J, Boehm, Jeffrey C, Kassisà, Skouki, Cobb, Melanie H, Young, Peter R, Abdel-Meguid, Sherin, Adams, Jerry L, Goldsmith, Elizabeth J

Volltext

Potent and Selective Nonpeptide Inhibitors of Caspases 3 and 7 von Lee, Dennis, Long, Scott A, Murray, Jeffrey H, Adams, Jerry L, Nuttall, Mark E, Nadeau, Daniel P, Kikly, Kristine, Winkler, James D, Sung, Chiu-Mei, Ryan, M. Dominic, Levy, Mark A, Keller, Paul M, DeWolf, Walter E

Volltext

Role of p38 Mitogen-Activated Protein Kinase in Rhinovirus-Induced Cytokine Production by Bronchial Epithelial Cells von Griego, Sandra D, Weston, Cynthia B, Adams, Jerry L, Tal-Singer, Ruth, Dillon, Susan B

Volltext

Optimization of triarylimidazoles for Tie2: Influence of conformation on potency von Johnson, Neil W., Semones, Marcus, Adams, Jerry L., Hansbury, Michael, Winkler, Jim

Volltext

Hypertensive end-organ damage and premature mortality are p38 mitogen-activated protein kinase-dependent in a rat model of cardiac hypertrophy and dysfunction von BEHR, Thomas M, NERURKAR, Sandhya S, OHLSTEIN, Eliot H, ANGERMANN, Christiane E, ADAMS, Jerry L, SISKO, Joseph, SACKNER-BERNSTEIN, Jonathan D, WILLETTE, Robert N, NELSON, Allen H, COATNEY, Robert W, WOODS, Tina N, SULPIZIO, Anthony, CHANDRA, Sudeep, BROOKS, David P, KUMAR, Sanjay, LEE, John C

Volltext

Inhibition of p38 MAP kinase as a therapeutic strategy von Lee, John C, Kumar, Sanjay, Griswold, Don E, Underwood, David C, Votta, Bartholomew J, Adams, Jerry L

Volltext

Discovery of GSK1070916, a Potent and Selective Inhibitor of Aurora B/C Kinase von Adams, Nicholas D, Adams, Jerry L, Burgess, Joelle L, Chaudhari, Amita M, Copeland, Robert A, Donatelli, Carla A, Drewry, David H, Fisher, Kelly E, Hamajima, Toshihiro, Hardwicke, Mary Ann, Huffman, William F, Koretke-Brown, Kristin K, Lai, Zhihong V, McDonald, Octerloney B, Nakamura, Hiroko, Newlander, Ken A, Oleykowski, Catherine A, Parrish, Cynthia A, Patrick, Denis R, Plant, Ramona, Sarpong, Martha A, Sasaki, Kosuke, Schmidt, Stanley J, Silva, Domingos J, Sutton, David, Tang, Jun, Thompson, Christine S, Tummino, Peter J, Wang, Jamin C, Xiang, Hong, Yang, Jingsong, Dhanak, Dashyant

Volltext

Metabolism and disposition of oral dabrafenib in cancer patients: proposed participation of aryl nitrogen in carbon-carbon bond cleavage via decarboxylation following enzymatic oxi... von Bershas, David A, Ouellet, Daniele, Mamaril-Fishman, Donna B, Nebot, Noelia, Carson, Stanley W, Blackman, Samuel C, Morrison, Royce A, Adams, Jerry L, Jurusik, Kristen E, Knecht, Dana M, Gorycki, Peter D, Richards-Peterson, Lauren E

Volltext

p38 Mitogen-Activated Protein Kinase Inhibitors— Mechanisms and Therapeutic Potentials von Lee, John C., Kassis, Shouki, Kumar, Sanjay, Badger, Alison, Adams, Jerry L.

Volltext

Pyridinylimidazole inhibitors of Tie2 kinase von Semones, Marcus, Feng, Yanhong, Johnson, Neil, Adams, Jerry L., Winkler, Jim, Hansbury, Michael

Volltext

Pyridinyl Imidazole Inhibitors of p38 Mitogen-activated Protein Kinase Bind in the ATP Site von Young, P R, McLaughlin, M M, Kumar, S, Kassis, S, Doyle, M L, McNulty, D, Gallagher, T F, Fisher, S, McDonnell, P C, Carr, S A, Huddleston, M J, Seibel, G, Porter, T G, Livi, G P, Adams, J L, Lee, J C

Volltext

Identification of a Selective Nonpeptide Antagonist of the Anaphylatoxin C3a Receptor That Demonstrates Antiinflammatory Activity in Animal Models von Ames, Robert S, Lee, Dennis, Foley, James J, Jurewicz, Anthony J, Tornetta, Mark A, Bautsch, Wilfried, Settmacher, Britta, Klos, Andreas, Erhard, Karl F, Cousins, Russell D, Sulpizio, Anthony C, Hieble, J. Paul, McCafferty, Gerald, Ward, Keith W, Adams, Jerry L, Bondinell, William E, Underwood, David C, Osborn, Ruth R, Badger, Alison M, Sarau, Henry M

Volltext

Acquisition of Sensitivity of Stress-activated Protein Kinases to the p38 Inhibitor, SB 203580, by Alteration of One or More Amino Acids within the ATP Binding Pocket von Gum, R J, McLaughlin, M M, Kumar, S, Wang, Z, Bower, M J, Lee, J C, Adams, J L, Livi, G P, Goldsmith, E J, Young, P R

Volltext

Two convenient regioselective syntheses of 1- N-alkyl-3-aryl-4-[pyrimidin-4-yl]-pyrazoles von Ralph, Jeffrey M., Faitg, Thomas H., Silva, Domingos J., Feng, Yanhong, Blackledge, Charles W., Adams, Jerry L.

Volltext

Use of Spin Echo Magic Angle Spinning (1)H NMR in Reaction Monitoring in Combinatorial Organic Synthesis von Garigipati, Ravi S., Adams, Bruce, Adams, Jerry L., Sarkar, Susanta K.

Volltext

Use of Spin Echo Magic Angle Spinning 1H NMR in Reaction Monitoring in Combinatorial Organic Synthesis von Garigipati, Ravi S, Adams, Bruce, Adams, Jerry L, Sarkar, Susanta K

Volltext

Abstract 5554: Preclinical characterization of GSK532, a novel STING agonist with potent anti-tumor activity von Yang, Jingsong, Adam, Michael, Clemens, Jim, Creech, Katrina, Schneck, Jess, Pasikanti, Kishore, Tran, Jean-Luc, Joglekar, Devika, Hopson, Chris, Pesiridis, Scott, Ramanjulu, Joshi, Lian, Yiqian, Adams, Jerry L., Smothers, James, Hoos, Axel

Volltext

Regioselective synthesis of .DELTA.6-, .DELTA.7-, and .DELTA.8-14.alpha.-cyanosterol derivatives: versatile precursors to 14.alpha.-demethylase inhibitors von Gallagher, Timothy F, Adams, Jerry L

Volltext