Structure-Guided Discovery of Aminoquinazolines as Brain-Penetrant and Selective LRRK2 Inhibitors von Keylor, Mitchell H, Gulati, Anmol, Kattar, Solomon D, Johnson, Rebecca E, Chau, Ryan W, Margrey, Kaila A, Ardolino, Michael J, Zarate, Cayetana, Poremba, Kelsey E, Simov, Vladimir, Morriello, Gregori J, Acton, John J, Pio, Barbara, Yan, Xin, Palte, Rachel L, McMinn, Spencer E, Nogle, Lisa, Lesburg, Charles A, Adpressa, Donovon, Lin, Shishi, Neelamkavil, Santhosh, Liu, Ping, Su, Jing, Hegde, Laxminarayan G, Woodhouse, Janice D, Faltus, Robert, Xiong, Tina, Ciaccio, Paul J, Piesvaux, Jennifer, Otte, Karin M, Wood, Harold B, Kennedy, Matthew E, Bennett, David Jonathan, DiMauro, Erin F, Fell, Matthew J, Fuller, Peter H

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Discovery of (2R)-2-(3-{3-[(4-Methoxyphenyl)carbonyl]-2-methyl-6-(trifluoromethoxy)-1H-indol-1-yl}phenoxy)butanoic Acid (MK-0533): A Novel Selective Peroxisome Proliferator-Activat... von Acton, John J, Akiyama, Taro E, Chang, Ching H, Colwell, Lawrence, Debenham, Sheryl, Doebber, Thomas, Einstein, Monica, Liu, Kun, McCann, Margaret E, Moller, David E, Muise, Eric S, Tan, Yugen, Thompson, John R, Wong, Kenny K, Wu, Margaret, Xu, Libo, Meinke, Peter T, Berger, Joel P, Wood, Harold B

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Discovery and Optimization of N‑Heteroaryl Indazole LRRK2 Inhibitors von Logan, Kaitlyn M., Kaplan, Will, Simov, Vladimir, Zhou, Hua, Li, Derun, Torres, Luis, Morriello, Gregori J., Acton, John J., Pio, Barbara, Chen, Yi-Heng, Keylor, Mitchell H., Johnson, Rebecca, Kattar, Solomon D., Chau, Ryan, Yan, Xin, Ardolino, Michael, Zarate, Cayetana, Otte, Karin M., Palte, Rachel L., Xiong, Tina, McMinn, Spencer E., Lin, Shishi, Neelamkavil, Santhosh F., Liu, Ping, Su, Jing, Hegde, Laxminarayan G., Woodhouse, Janice D., Moy, Lily Y., Ciaccio, Paul J., Piesvaux, Jennifer, Zebisch, Matthias, Henry, Clare, Barker, John, Wood, Harold B., Kennedy, Matthew E., DiMauro, Erin F., Fell, Matthew J., Fuller, Peter H.

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Benzoyl 2-methyl indoles as selective PPARγ modulators von Acton, John J., Black, Regina M., Jones, A. Brian, Moller, David E., Colwell, Lawrence, Doebber, Thomas W., MacNaul, Karen L., Berger, Joel, Wood, Harold B.

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Selective PPARγ modulators with improved pharmacological profiles von Liu, Kun, Black, Regina M., Acton, John J., Mosley, Ralph, Debenham, Sheryl, Abola, Ramon, Yang, Meng, Tschirret-Guth, Richard, Colwell, Lawrence, Liu, Cherrie, Wu, Margaret, Wang, Chuanlin F., MacNaul, Karen L., McCann, Margaret E., Moller, David E., Berger, Joel P., Meinke, Peter T., Jones, A. Brian, Wood, Harold B.

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Discovery and Optimization of Potent, Selective, and Brain-Penetrant 1‑Heteroaryl‑1H‑Indazole LRRK2 Kinase Inhibitors for the Treatment of Parkinson’s Disease von Candito, David A., Simov, Vladimir, Gulati, Anmol, Kattar, Solomon, Chau, Ryan W., Lapointe, Blair T., Methot, Joey L., DeMong, Duane E., Graham, Thomas H., Kurukulasuriya, Ravi, Keylor, Mitchell H., Tong, Ling, Morriello, Gregori J., Acton, John J., Pio, Barbara, Liu, Weiguo, Scott, Jack D., Ardolino, Michael J., Martinot, Theodore A., Maddess, Matthew L., Yan, Xin, Gunaydin, Hakan, Palte, Rachel L., McMinn, Spencer E., Nogle, Lisa, Yu, Hongshi, Minnihan, Ellen C., Lesburg, Charles A., Liu, Ping, Su, Jing, Hegde, Laxminarayan G., Moy, Lily Y., Woodhouse, Janice D., Faltus, Robert, Xiong, Tina, Ciaccio, Paul, Piesvaux, Jennifer A., Otte, Karin M., Kennedy, Matthew E., Bennett, David Jonathan, DiMauro, Erin F., Fell, Matthew J., Neelamkavil, Santhosh, Wood, Harold B., Fuller, Peter H., Ellis, J. Michael

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Discovery and Optimization of Potent, Selective, and Brain-Penetrant 1-Heteroaryl-1 H -Indazole LRRK2 Kinase Inhibitors for the Treatment of Parkinson's Disease von Candito, David A, Simov, Vladimir, Gulati, Anmol, Kattar, Solomon, Chau, Ryan W, Lapointe, Blair T, Methot, Joey L, DeMong, Duane E, Graham, Thomas H, Kurukulasuriya, Ravi, Keylor, Mitchell H, Tong, Ling, Morriello, Gregori J, Acton, John J, Pio, Barbara, Liu, Weiguo, Scott, Jack D, Ardolino, Michael J, Martinot, Theodore A, Maddess, Matthew L, Yan, Xin, Gunaydin, Hakan, Palte, Rachel L, McMinn, Spencer E, Nogle, Lisa, Yu, Hongshi, Minnihan, Ellen C, Lesburg, Charles A, Liu, Ping, Su, Jing, Hegde, Laxminarayan G, Moy, Lily Y, Woodhouse, Janice D, Faltus, Robert, Xiong, Tina, Ciaccio, Paul, Piesvaux, Jennifer A, Otte, Karin M, Kennedy, Matthew E, Bennett, David Jonathan, DiMauro, Erin F, Fell, Matthew J, Neelamkavil, Santhosh, Wood, Harold B, Fuller, Peter H, Ellis, J Michael

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Benzoyl 2-methyl indoles as selective PPARgamma modulators von Acton, 3rd, John J, Black, Regina M, Jones, A Brian, Moller, David E, Colwell, Lawrence, Doebber, Thomas W, Macnaul, Karen L, Berger, Joel, Wood, Harold B

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Selective PPARgamma modulators with improved pharmacological profiles von Liu, Kun, Black, Regina M, Acton, 3rd, John J, Mosley, Ralph, Debenham, Sheryl, Abola, Ramon, Yang, Meng, Tschirret-Guth, Richard, Colwell, Lawrence, Liu, Cherrie, Wu, Margaret, Wang, Chuanlin F, MacNaul, Karen L, McCann, Margaret E, Moller, David E, Berger, Joel P, Meinke, Peter T, Jones, A Brian, Wood, Harold B

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Correction to Discovery of (2 R )-2-(3-{3-[(4-Methoxyphenyl)carbonyl]-2-methyl-6-(trifluoromethoxy)-1 H -indol-1-yl}phenoxy)butanoic Acid (MK-0533): A Novel Selective Peroxisome Pr... von Acton, John J., Akiyama, Taro E., Chang, Ching H., Colwell, Lawrence, Debenham, Sheryl, Doebber, Thomas, Einstein, Monica, Liu, Kun, McCann, Margaret E., Moller, David E., Muise, Eric S., Tan, Yejun, Thompson, John R., Wong, Kenny K., Wu, Margaret, Xu, Libo, Meinke, Peter T., Berger, Joel P., Wood, Harold B.

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Correction to Discovery of (2R)‑2-(3-{3-[(4-Methoxyphenyl)carbonyl]-2-methyl-6-(trifluoromethoxy)‑1H‑indol-1-yl}phenoxy)butanoic Acid (MK-0533): A Novel Selective Peroxisome Prolif... von Acton, John J, Akiyama, Taro E, Chang, Ching H, Colwell, Lawrence, Debenham, Sheryl, Doebber, Thomas, Einstein, Monica, Liu, Kun, McCann, Margaret E, Moller, David E, Muise, Eric S, Tan, Yejun, Thompson, John R, Wong, Kenny K, Wu, Margaret, Xu, Libo, Meinke, Peter T, Berger, Joel P, Wood, Harold B

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Selective Protection and Relative Importance of the Carboxylic Acid Groups of Zaragozic Acid A for Squalene Synthase Inhibition von Biftu, Tesfaye, Acton, John J, Berger, Gregory D, Bergstrom, James D, Dufresne, Claude, Kurtz, Marc M, Marquis, Robert W, Parsons, William H, Rew, Deborah R, Wilson, Kenneth E

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Discovery of (2 R )-2-(3-{3-[(4-Methoxyphenyl)carbonyl]-2-methyl-6-(trifluoromethoxy)-1 H -indol-1-yl}phenoxy)butanoic Acid (MK-0533): A Novel Selective Peroxisome Proliferator-Act... von Acton, John J., Akiyama, Taro E., Chang, Ching H., Colwell, Lawrence, Debenham, Sheryl, Doebber, Thomas, Einstein, Monica, Liu, Kun, McCann, Margaret E., Moller, David E., Muise, Eric S., Tan, Yugen, Thompson, John R., Wong, Kenny K., Wu, Margaret, Xu, Libo, Meinke, Peter T., Berger, Joel P., Wood, Harold B.

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Discovery of (2R)-2-(3-{3-[(4-Methoxyphenyl)carbonyl]-2-methyl-6-(trifluoromethoxy)-1H-indol-1-yl}phenoxy)butanoic Acid (MK-0533): A Novel Selective Peroxisome Proliferator-Activat... von ACTON, John J, AKIYAMA, Taro E, MUISE, Eric S, YUGEN TAN, THOMPSON, John R, WONG, Kenny K, WU, Margaret, LIBO XU, MEINKE, Peter T, BERGER, Joel P, WOOD, Harold B, CHANG, Ching H, COLWELL, Lawrence, DEBENHAM, Sheryl, DOEBBER, Thomas, EINSTEIN, Monica, KUN LIU, MCCANN, Margaret E, MOLLER, David E

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2-AMINOQUINAZOLINES AS LRRK2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF von MARGREY, Kaila, A, YAN, Xin, CHAU, Ryan, GULATI, Anmol, FULLER, Peter, H, KATTAR, Solomon, ACTON, John, J., III, LI, Derun, KEYLOR, Mitchell, H, JOHNSON, Rebecca Elizabeth, MORRIELLO, Gregori, J

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3-(1H-PYRAZOL-4-YL)PYRIDINE ALLOSTERIC MODULATORS OF THE M4 MUSCARINIC ACETYLCHOLINE RECEPTOR von TONG, Ling, MULHEARN, James, SELYUTIN, Oleg, B, RADA, Vanessa, L, ZHANG, Fengqi, ACTON, John, J., III, EGBERTSON, Melissa, SCHUBERT, Jeffrey, W, TELLERS, David, M, BAO, Jianming, LO, Michael Man-Chu, LI, Chunsing, HENDERSON, Timothy, J, HARRISON, Scott, T, GAO, Xiaolei, MAZZOLA, Robert, D., Jr, MENG, Zhaoyang

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2-AMINOQUINAZOLINES AS LRRK2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF von MARGREY, Kaila, A, YAN, Xin, CHAU, Ryan, GULATI, Anmol, FULLER, Peter, H, KATTAR, Solomon, ACTON, John, J., III, LI, Derun, KEYLOR, Mitchell, H, JOHNSON, Rebecca Elizabeth, MORRIELLO, Gregori, J

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Synthesis and derivatization of a versatile α-substituted lactam dipeptide isostere von Acton, John J., Jones, A.Brian

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Tetrapeptide derived inhibitors of complexation of a class II MHC: fully unnatural ligands von Brian Jones, A., Acton, John J., Adams, Alan D., Yuen, Winston, Nichols, Elizabeth A., Schwartz, Cheryl D., Wicker, Linda S., Hermes, Jeffrey D.

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3-(1H-PYRAZOL-4-YL)PYRIDINE ALLOSTERIC MODULATORS OF THE M4 MUSCARINIC ACETYLCHOLINE RECEPTOR von SUZUKI, Takao, HARRISON, Scott Timothy, SELYUTIN, Oleg, B, FERGUSON, Ronald, III, ZHANG, Fengqi, ACTON, John, J., III, EGBERTSON, Melissa, BAO, Jianming, LO, Michael Man-Chu, HENDERSON, Timothy, J, NA, Meng, KNOWLES, Sandra, L, GAO, Xiaolei, MAZZOLA, Robert, D., Jr, DENG, Qiaolin

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