Combinations with Allosteric SHP2 Inhibitor TNO155 to Block Receptor Tyrosine Kinase Signaling von Liu, Chen, Lu, Hengyu, Wang, Hongyun, Loo, Alice, Zhang, Xiamei, Yang, Guizhi, Kowal, Colleen, Delach, Scott, Wang, Ye, Goldoni, Silvia, Hastings, William D, Wong, Karrie, Gao, Hui, Meyer, Matthew J, Moody, Susan E, LaMarche, Matthew J, Engelman, Jeffrey A, Williams, Juliet A, Hammerman, Peter S, Abrams, Tinya J, Mohseni, Morvarid, Caponigro, Giordano, Hao, Huai-Xiang

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Mechanistic Insights of an Immunological Adverse Event Induced by an Anti-KIT Antibody Drug Conjugate and Mitigation Strategies von L'Italien, Lawrence, Orozco, Olivia, Abrams, Tinya, Cantagallo, Lisa, Connor, Anu, Desai, Jayesh, Ebersbach, Hilmar, Gelderblom, Hans, Hoffmaster, Keith, Lees, Emma, Maacke, Heiko, Schleyer, Siew, Skegro, Darko, Lee-Hoeflich, Si Tuen

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SU11248 Inhibits KIT and Platelet-derived Growth Factor Receptor β in Preclinical Models of Human Small Cell Lung Cancer von Abrams, Tinya J, Lee, Leslie B, Murray, Lesley J, Pryer, Nancy K, Cherrington, Julie M

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Tumor Intrinsic Efficacy by SHP2 and RTK Inhibitors in KRAS-Mutant Cancers von Hao, Huai-Xiang, Wang, Hongyun, Liu, Chen, Kovats, Steven, Velazquez, Roberto, Lu, Hengyu, Pant, Bhavesh, Shirley, Matthew, Meyer, Matthew J, Pu, Minying, Lim, Joanne, Fleming, Michael, Alexander, LeighAnn, Farsidjani, Ali, LaMarche, Matthew J, Moody, Susan, Silver, Serena J, Caponigro, Giordano, Stuart, Darrin D, Abrams, Tinya J, Hammerman, Peter S, Williams, Juliet, Engelman, Jeffrey A, Goldoni, Silvia, Mohseni, Morvarid

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Preclinical Antitumor Activity of a Novel Anti-c-KIT Antibody-Drug Conjugate against Mutant and Wild-type c-KIT-Positive Solid Tumors von Abrams, Tinya, Connor, Anu, Fanton, Christie, Cohen, Steven B, Huber, Thomas, Miller, Kathy, Hong, E Erica, Niu, Xiaohong, Kline, Janine, Ison-Dugenny, Marjorie, Harris, Sarah, Walker, Dana, Krauser, Klaus, Galimi, Francesco, Wang, Zhen, Ghoddusi, Majid, Mansfield, Keith, Lee-Hoeflich, Si Tuen, Holash, Jocelyn, Pryer, Nancy, Kluwe, William, Ettenberg, Seth A, Sellers, William R, Lees, Emma, Kwon, Paul, Abraham, Judith A, Schleyer, Siew C

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Neutralization of prolactin receptor function by monoclonal antibody LFA102, a novel potential therapeutic for the treatment of breast cancer von Damiano, Jason S, Rendahl, Katherine G, Karim, Christopher, Embry, Millicent G, Ghoddusi, Majid, Holash, Jocelyn, Fanidi, Abdallah, Abrams, Tinya J, Abraham, Judith A

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Preclinical evaluation of the tyrosine kinase inhibitor SU11248 as a single agent and in combination with “standard of care” therapeutic agents for the treatment of breast cancer... von Abrams, Tinya J, Murray, Lesley J, Pesenti, Enrico, Holway, Vicky Walker, Colombo, Tina, Lee, Leslie B, Cherrington, Julie M, Pryer, Nancy K

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BRD9 degraders as chemosensitizers in acute leukemia and multiple myeloma von Weisberg, Ellen, Chowdhury, Basudev, Meng, Chengcheng, Case, Abigail E., Ni, Wei, Garg, Swati, Sattler, Martin, Azab, Abdel Kareem, Sun, Jennifer, Muz, Barbara, Sanchez, Dana, Toure, Anthia, Stone, Richard M., Galinsky, Ilene, Winer, Eric, Gleim, Scott, Gkountela, Sofia, Kedves, Alexia, Harrington, Edmund, Abrams, Tinya, Zoller, Thomas, Vaupel, Andrea, Manley, Paul, Faller, Michael, Chung, BoYee, Chen, Xin, Busenhart, Philipp, Stephan, Christine, Calkins, Keith, Bonenfant, Debora, Thoma, Claudio R., Forrester, William, Griffin, James D.

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In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: Determination of... von MENDEL, Dirk B, LAIRD, A. Douglas, MURRAY, Lesley J, CARVER, Jeremy, CHAN, Emily, MOSS, Katherine G, HAZNEDAR, Joshua Ö, SUKBUNTHERNG, Juthamas, BLAKE, Robert A, LI SUN, CHO TANG, MILLER, Todd, XIAOHUA XIN, SHIRAZIAN, Sheri, MCMAHON, Gerald, CHERRINGTON, Julie M, LOUIE, Sharianne G, CHRISTENSEN, James G, GUANGMIN LI, SCHRECK, Randall E, ABRAMS, Tinya J, NGAI, Theresa J, LEE, Leslie B

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SU11248 is a novel FLT3 tyrosine kinase inhibitor with potent activity in vitro and in vivo von O'Farrell, Anne-Marie, Abrams, Tinya J., Yuen, Helene A., Ngai, Theresa J., Louie, Sharianne G., Yee, Kevin W.H., Wong, Lily M., Hong, Weiru, Lee, Leslie B., Town, Ajia, Smolich, Beverly D., Manning, William C., Murray, Lesley J., Heinrich, Michael C., Cherrington, Julie M.

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Nicotinamide Phosphoribosyltransferase Inhibitor as a Novel Payload for Antibody–Drug Conjugates von Karpov, Alexei S, Abrams, Tinya, Clark, Suzanna, Raikar, Ankita, D’Alessio, Joseph A, Dillon, Michael P, Gesner, Thomas G, Jones, Darryl, Lacaud, Marion, Mallet, William, Martyniuk, Piotr, Meredith, Erik, Mohseni, Morvarid, Nieto-Oberhuber, Cristina M, Palacios, Daniel, Perruccio, Francesca, Piizzi, Grazia, Zurini, Mauro, Bialucha, Carl Uli

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SU11248 inhibits tumor growth and CSF-1R-dependent osteolysis in an experimental breast cancer bone metastasis model von Murray, Lesley J, Abrams, Tinya J, Long, Kelly R, Ngai, Theresa J, Olson, Lisa M, Hong, Weiru, Keast, Paul K, Brassard, Jacqueline A, O'Farrell, Anne Marie, Cherrington, Julie M, Pryer, Nancy K

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PCA062, a P-cadherin Targeting Antibody-Drug Conjugate, Displays Potent Antitumor Activity Against P-cadherin-expressing Malignancies von Sheng, Qing, D'Alessio, Joseph A, Menezes, Daniel L, Karim, Christopher, Tang, Yan, Tam, Angela, Clark, Suzanna, Ying, Chi, Connor, Anu, Mansfield, Keith G, Rondeau, Jean-Michel, Ghoddusi, Majid, Geyer, Felipe C, Gu, Jane, McLaughlin, Margaret E, Newcombe, Rick, Elliot, GiNell, Tschantz, William R, Lehmann, Sylvie, Fanton, Christie P, Miller, Kathy, Huber, Thomas, Rendahl, Katherine G, Jeffry, Ursula, Pryer, Nancy K, Lees, Emma, Kwon, Paul, Abraham, Judith A, Damiano, Jason S, Abrams, Tinya J

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CHIR-258 Is Efficacious in A Newly Developed Fibroblast Growth Factor Receptor 3–Expressing Orthotopic Multiple Myeloma Model in Mice von XIAOHUA XIN, ABRAMS, Tinya J, TRUDEL, Suzanne, JALLAL, Bahija, MENDEL, Dirk B, HEISE, Carla C, HOLLENBACH, Paul W, RENDAHL, Katherine G, YAN TANG, OEI, Yoko A, EMBRY, Millicent G, SWINARSKI, Debbie E, GARRETT, Evelyn N, PRYER, Nancy K

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In Vivo Assessment of Antiangiogenic Activity of SU6668 in an Experimental Colon Carcinoma Model von MARZOLA, Pasquina, DEGRASSI, Anna, ABRAMS, Tinya, MURRAY, Lesley, OSCULATI, Francesco, CALDERAN, Laura, FARACE, Paolo, CRESCIMANNO, Caterina, NICOLATO, Elena, GIUSTI, Anna, PESENTI, Enrico, TERRON, Andrea, SBARBATI, Andrea

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A model of APL with FLT3 mutation is responsive to retinoic acid and a receptor tyrosine kinase inhibitor, SU11657 von Sohal, Jastinder, Phan, Vernon T., Chan, Philip V., Davis, Elizabeth M., Patel, Bhumi, Kelly, Louise M., Abrams, Tinya J., O’Farrell, Anne Marie, Gilliland, D. Gary, Le Beau, Michelle M., Kogan, Scott C.

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Discovery of LSZ102, a Potent, Orally Bioavailable Selective Estrogen Receptor Degrader (SERD) for the Treatment of Estrogen Receptor Positive Breast Cancer von Tria, George S, Abrams, Tinya, Baird, Jason, Burks, Heather E, Firestone, Brant, Gaither, L. Alex, Hamann, Lawrence G, He, Guo, Kirby, Christina A, Kim, Sunkyu, Lombardo, Franco, Macchi, Kaitlin J, McDonnell, Donald P, Mishina, Yuji, Norris, John D, Nunez, Jill, Springer, Clayton, Sun, Yingchuan, Thomsen, Noel M, Wang, Chunrong, Wang, Jianling, Yu, Bing, Tiong-Yip, Choi-Lai, Peukert, Stefan

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Exquisite Sensitivity to Dual BRG1/BRM ATPase Inhibitors Reveals Broad SWI/SNF Dependencies in Acute Myeloid Leukemia von Rago, Florencia, Rodrigues, Lindsey Ulkus, Bonney, Megan, Sprouffske, Kathleen, Kurth, Esther, Elliott, GiNell, Ambrose, Jessi, Aspesi, Peter, Oborski, Justin, Chen, Julie T, McDonald, E Robert, Mapa, Felipa A, Ruddy, David A, Kauffmann, Audrey, Abrams, Tinya, Bhang, Hyo-Eun C, Jagani, Zainab

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A First-in-Human, Phase I, Multicenter, Open-Label, Dose-Escalation Study of PCA062: An Antibody-Drug Conjugate Targeting P-Cadherin, in Patients With Solid Tumors von Duca, Matteo, Lim, Darren Wan-Teck, Subbiah, Vivek, Takahashi, Shunji, Sarantopoulos, John, Varga, Andrea, D'Alessio, Joseph A, Abrams, Tinya, Sheng, Qing, Tan, Eugene Youchin, Rosa, Maria Santos, Gonzalez-Maffe, Juan, Sand-Dejmek, Janna, Fabre, Claire, Martin, Miguel

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Discovery of an Acrylic Acid Based Tetrahydroisoquinoline as an Orally Bioavailable Selective Estrogen Receptor Degrader for ERα+ Breast Cancer von Burks, Heather E, Abrams, Tinya, Kirby, Christina A, Baird, Jason, Fekete, Alexander, Hamann, Lawrence G, Kim, Sunkyu, Lombardo, Franco, Loo, Alice, Lubicka, Danuta, Macchi, Kaitlin, McDonnell, Donald P, Mishina, Yuji, Norris, John D, Nunez, Jill, Saran, Chitra, Sun, Yingchuan, Thomsen, Noel M, Wang, Chunrong, Wang, Jianling, Peukert, Stefan

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