Adoptive immunotherapy with genetically engineered T cells: modification of the IgG1 Fc ‘spacer’ domain in the extracellular moiety of chimeric antigen receptors avoids ‘off-target... von Hombach, A, Hombach, A A, Abken, H

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Intra-tumoral production of IL18, but not IL12, by TCR-engineered T cells is non-toxic and counteracts immune evasion of solid tumors von Kunert, A., Chmielewski, M., Wijers, R., Berrevoets, C., Abken, H., Debets, R.

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Deregulation and epigenetic modification of BCL2-family genes cause resistance to venetoclax in hematologic malignancies von Thomalla, D., Beckmann, L., Grimm, C., Oliverio, M., Meder, L., Herling, C.D., Nieper, P., Feldmann, T., Merkel, O., Lorsy, E., da Palma Guerreiro, A., von Jan, J., Kisis, I., Wasserburger, E., Claasen, J., Faitschuk-Meyer, E., Altmüller, J., Nürnberg, P., Yang, T.-P., Lienhard, M., Herwig, R., Kreuzer, K.-A., Pallasch, C.P., Büttner, R., Schäfer, S.C., Hartley, J., Abken, H., Peifer, M., Kashkar, H., Knittel, G., Eichhorst, B., Ullrich, R.T., Herling, M., Reinhardt, H.C., Hallek, M., Schweiger, M.R., Frenzel, L.P.

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A dual chain chimeric antigen receptor (CAR) in the native antibody format for targeting immune cells towards cancer cells without the need of an scFv von Faitschuk, E, Nagy, V, Hombach, A A, Abken, H

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Noncanonical effector functions of the T-memory–like T-PLL cell are shaped by cooperative TCL1A and TCR signaling von Oberbeck, S., Schrader, A., Warner, K., Jungherz, D., Crispatzu, G., von Jan, J., Chmielewski, M., Ianevski, A., Diebner, H.H., Mayer, P., Kondo Ados, A., Wahnschaffe, L., Braun, T., Müller, T.A., Wagle, P., Bouska, A., Neumann, T., Pützer, S., Varghese, L., Pflug, N., Thelen, M., Makalowski, J., Riet, N., Göx, H.J.M., Rappl, G., Altmüller, J., Kotrová, M., Persigehl, T., Hopfinger, G., Hansmann, M.L., Schlößer, H., Stilgenbauer, S., Dürig, J., Mougiakakos, D., von Bergwelt-Baildon, M., Roeder, I., Hartmann, S., Hallek, M., Moriggl, R., Brüggemann, M., Aittokallio, T., Iqbal, J., Newrzela, S., Abken, H., Herling, M.

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CD28 cosignalling does not affect the activation threshold in a chimeric antigen receptor-redirected T-cell attack von Chmielewski, M, Hombach, A A, Abken, H

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T cells redirected by a CD3ζ chimeric antigen receptor can establish self-antigen-specific tumour protection in the long term von Chmielewski, M, Rappl, G, Hombach, A A, Abken, H

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Redirecting human CD4+CD25+ regulatory T cells from the peripheral blood with pre-defined target specificity von Hombach, A A, Kofler, D, Rappl, G, Abken, H

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Transfer of mRNA encoding recombinant immunoreceptors reprograms CD4+ and CD8+ T cells for use in the adoptive immunotherapy of cancer von Birkholz, K, Hombach, A, Krug, C, Reuter, S, Kershaw, M, Kämpgen, E, Schuler, G, Abken, H, Schaft, N, Dörrie, J

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Development of Adoptive Cell Therapy for Cancer: A Clinical Perspective von HAWKINS, Robert E, GILHAM, David E, DEBETS, Reno, ESHHAR, Zelig, TAYLOR, Naomi, ABKEN, Hinrich, SCHUMACHER, Ton N

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Chimäre Antigenrezeptoren (CAR) – universelle Werkzeuge in der zellulären Immuntherapie von Holzinger, A, Abken, H

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Tumor-specific T cell activation by recombinant immunoreceptors: CD3 zeta signaling and CD28 costimulation are simultaneously required for efficient IL-2 secretion and can be integ... von Hombach, A, Wieczarkowiecz, A, Marquardt, T, Heuser, C, Usai, L, Pohl, C, Seliger, B, Abken, H

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Chimäre Antigenrezeptoren (CAR) – universelle Werkzeuge in der zellulären Immuntherapie von Holzinger, A., Abken, H.

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62 Proffered Paper: Regression of Metastatic Melanoma by Targeting Melanoma Stem Cells von Abken, H, Schmidt, P, Schlaak, M, Hombach, A.A, Bangard, C, Kurschat, P, Zigrino, P

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Coexpressed Catalase Protects Chimeric Antigen Receptor-Redirected T Cells as well as Bystander Cells from Oxidative Stress-Induced Loss of Antitumor Activity von Ligtenberg, Maarten A, Mougiakakos, Dimitrios, Mukhopadhyay, Madhura, Witt, Kristina, Lladser, Alvaro, Chmielewski, Markus, Riet, Tobias, Abken, Hinrich, Kiessling, Rolf

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Tuning tumor-specific T-cell activation: a matter of costimulation? von Abken, Hinrich, Hombach, Andreas, Heuser, Claudia, Kronfeld, Kai, Seliger, Barbara

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340 T CELLS REDIRECTED BY A CHIMERIC ANTIGEN RECEPTOR RECOGNIZING HBsAg EFFICIENTLY CONTROL HBV IN VIVO IN TRANSGENIC MICE von Krebs, K, Böttinger, N, Huang, L.-R, Chmielewski, M, Arzberger, S, Gasteiger, G, Schmitt, E, Bohne, F, Aichler, M, Uckert, W, Abken, H, Heikenwälder, M, Knolle, P, Protzer, U

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T cells redirected by a chimeric antigen receptor recognizing HBsAg efficiently control HBV in vivo in transgenic mice von Krebs, K, Böttinger, N, Huang, L, Chmielewski, M, Uckert, W, Abken, H, Heikenwälder, M, Knolle, P, Protzer, U

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An interleukin 12 p40-IgG2b fusion protein abrogates T cell mediated inflammation: anti-inflammatory activity in Crohn’s disease and experimental colitis in vivo von Stallmach, A, Marth, T, Weiß, B, Wittig, B M, Hombach, A, Schmidt, C, Neurath, M, Zeitz, M, Zeuzem, S, Abken, H

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Engineered T cells redirected by 2nd and 3rd generation immunoreceptors - The weal and woe of costimulation von Abken, H

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