Cellular immunotherapy on primary multiple myeloma expanded in a 3D bone marrow niche model von Braham, Maaike V. J., Minnema, Monique C., Aarts, Tineke, Sebestyen, Zsolt, Straetemans, Trudy, Vyborova, Anna, Kuball, Jurgen, Öner, F. Cumhur, Robin, Catherine, Alblas, Jacqueline

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Evaluating in vivo efficacy - toxicity profile of TEG001 in humanized mice xenografts against primary human AML disease and healthy hematopoietic cells von Johanna, Inez, Straetemans, Trudy, Heijhuurs, Sabine, Aarts-Riemens, Tineke, Norell, Håkan, Bongiovanni, Laura, de Bruin, Alain, Sebestyen, Zsolt, Kuball, Jürgen

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Sepantronium bromide (YM155) improves daratumumab-mediated cellular lysis of multiple myeloma cells by abrogation of bone marrow stromal cell-induced resistance von de Haart, Sanne J, Holthof, Lisa, Noort, Willy A, Minnema, Monique C, Emmelot, Maarten E, Aarts-Riemens, Tineke, Doshi, Parul, Sasser, Kate, Yuan, Huipin, de Bruijn, Joost, Martens, Anton C M, van de Donk, Niels W C J, Lokhorst, Henk M, Groen, Richard W J, Mutis, Tuna

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Characterization and modulation of anti-αβTCR antibodies and their respective binding sites at the βTCR chain to enrich engineered T cells von Kierkels, Guido J.J., van Diest, Eline, Hernández-López, Patricia, Scheper, Wouter, de Bruin, Anja C.M., Frijlink, Elselien, Aarts-Riemens, Tineke, van Dooremalen, Sanne F.J., Beringer, Dennis X., Oostvogels, Rimke, Kramer, Lovro, Straetemans, Trudy, Uckert, Wolfgang, Sebestyén, Zsolt, Kuball, Jürgen

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Forced overexpression of either of the two common human Foxp3 isoforms can induce regulatory T cells from CD4⁺CD25⁻ cells von Aarts-Riemens, Tineke, Emmelot, Maarten E, Verdonck, Leo F, Mutis, Tuna

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Human Regulatory T Cells Control Xenogeneic Graft-versus-Host Disease Induced by Autologous T Cells in RAG2−/−γc−/− Immunodeficient Mice von Mutis, Tuna, van Rijn, Rozemarijn S., Simonetti, Elles R., Aarts-Riemens, Tineke, Emmelot, Maarten E., van Bloois, Louis, Martens, Anton, Verdonck, Leo F., Ebeling, Saskia B.

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Identification of a 40S Ribosomal Protein S4–Derived H-Y Epitope Able to Elicit a Lymphoblast-Specific Cytotoxic T Lymphocyte Response von IVANOV, Roman, AARTS, Tineke, HOL, Samantha, DOORNENBAL, Angeline, HAGENBEEK, Anton, PETERSEN, Eefke, EBELING, Saskia

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TEG001 Insert Integrity from Vector Producer Cells until Medicinal Product von Straetemans, Trudy, Janssen, Anke, Jansen, Koen, Doorn, Ruud, Aarts, Tineke, van Muyden, Anna D.D., Simonis, Marieke, Bergboer, Judith, de Witte, Moniek, Sebestyen, Zsolt, Kuball, Jurgen

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Towards the Next Generation CAR T Cells with TEGs: In Vivo Efficacy — Toxicity Profile in Xenografts of Primary Human AML Disease and Healthy Bone Marrow von Straetemans, Trudy, Gan, Inez Johanna, Heijhuurs, Sabine, Kierkels, Guido, Jansen, Koen, Doorn, Ruud, Aarts, Tineke, Norrel, Haakan, Sebestyen, Zsolt, Kuball, Jurgen

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HLA‐DRB116‐restricted recognition of myeloid cells, including CD34+ CML progenitor cells von Ebeling, Saskia B., Ivanov, Roman, Hol, Samantha, Aarts, Tineke I., Hagenbeek, Anton, Verdonck, Leo F., Petersen, Eefke J.

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Cellular immunotherapy on primary multiple myeloma expanded in a 3D bone marrow niche model von Braham, Maaike V.J, Minnema, Monique C, Aarts, Tineke, Sebestyen, Zsolt, Straetemans, Trudy, Vyborova, Anna, Kuball, Jurgen, Öner, F. Cumhur, Robin, Catherine, Alblas, Jacqueline

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Uncovering the mode of action of engineered T cells in patient cancer organoids von Dekkers, Johanna F, Alieva, Maria, Cleven, Astrid, Keramati, Farid, Wezenaar, Amber K.L, van Vliet, Esmée J, Puschhof, Jens, Brazda, Peter, Johanna, Inez, Meringa, Angelo D, Rebel, Heggert G, Buchholz, Maj Britt, Barrera Román, Mario, Zeeman, Amber L, de Blank, Sam, Fasci, Domenico, Geurts, Maarten H, Cornel, Annelisa M, Driehuis, Else, Millen, Rosemary, Straetemans, Trudy, Nicolasen, Mara J.T, Aarts-Riemens, Tineke, Ariese, Hendrikus C.R, Johnson, Hannah R, van Ineveld, Ravian L, Karaiskaki, Froso, Kopper, Oded, Bar-Ephraim, Yotam E, Kretzschmar, Kai, Eggermont, Alexander M.M, Nierkens, Stefan, Wehrens, Ellen J, Stunnenberg, Henk G, Clevers, Hans, Kuball, Jürgen, Sebestyen, Zsolt, Rios, Anne C

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Abstract B003: Communication is key: Understanding the modulating effect of immune cell crosstalk on T cell therapy function von Wezenaar, Amber K.L., Honhoff, Celina, van Eck, Helena, Curiel, Elena Jiménez, Cornel, Annelisa M, Ringnalda, Femke C.A., Aarts-Riemens, Tineke, Kuball, Jürgen, Sebestyen, Zsolt, Clevers, Hans, Nierkens, Stefan, Dekkers, Johanna F., Wehrens, Ellen J., Alieva, Maria, Rios, Anne C.

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Host Dendritic Cell Vaccinations Combined with Donor Lymphocyte Infusions Induce Host and KLH Specific Immunity in Multiple Myeloma Patients von Kneppers, Evelien, Minnema, Monique C., Aarts, Tineke, Emmelot, Maarten E., Slaper-Cortenbach, Ineke, Westinga, Kasper, Mutis, Tuna, Lokhorst, Henk M.

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Accessory Cells of the Microenvironment Protect Multiple Myeloma from T-Cell Cytotoxicity through Cell Adhesion-Mediated Immune Resistance von DE HAART, Sanne J, VAN DE DONK, Niels W. C. J, LOKHORST, Henk M, MARTENS, Anton C, MITSIADES, Constantine S, MUTIS, Tuna, MINNEMA, Monique C, HUANG, Julie H, AARTS-RIEMENS, Tineke, BOVENSCHEN, Niels, HUIPIN YUAN, GROEN, Richard W. J, MCMILLIN, Douglas W, JAKUBIKOVA, Jana

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Lenalidomide Is Highly Effective in Patients with Relapsed Multiple Myeloma Following Allogeneic Stem Cell Transplantation and Increases the Frequency of CD4+FOXP3+ T Cells von Minnema, Monique C., van der Veer, Michael, Aarts, Tineke, Emmelot, Maarten, Mutis, Tuna, Lokhorst, Henk M.

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Evaluating in vivo efficacy - Toxicity profile of TEG001 in humanized mice xenografts against primary human AML disease and healthy hematopoietic cells von Johanna, Inez, Straetemans, Trudy, Heijhuurs, Sabine, Aarts-Riemens, Tineke, Norell, Håkan, Bongiovanni, Laura, De Bruin, Alain, Sebestyen, Zsolt, Kuball, Jürgen

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Induction of Potent Anti-Tumor Effects by Original and TCR-Redirected CD4 + Cytotoxic T Cells von Spaapen, Robbert M, van den Oudenalder, Kelly, van Elk, Maureen, Aarts, Tineke, Guichelaar, Teun, Groen, Richard WJ, Bloem, Andries C, Storm, Gert, Martens, Anton C, Lokhorst, Henk M, Mutis, Tuna

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Evaluating in vivo efficacy - toxicity profile of TEG001 in humanized mice xenografts against primary human AML disease and healthy hematopoietic cells von Johanna, Inez, Straetemans, Trudy, Heijhuurs, Sabine, Aarts-Riemens, Tineke, Norell, Håkan, Bongiovanni, Laura, de Bruin, Alain, Sebestyen, Zsolt, Kuball, Jürgen

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Generation of Graft-Versus-Leukemia (GVL)-Effector T Cells through Targeting of Leukemia-Associated HY Antigens Via TCR Transfer von Ivanov, Roman, Hol, Samantha, Aarts, Tineke, Hagenbeek, Anton, Ebeling, Saskia

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