Novel transforming growth factor beta receptor I kinase inhibitor galunisertib (LY2157299) in advanced hepatocellular carcinoma von Faivre, Sandrine, Santoro, Armando, Kelley, Robin K., Gane, Ed, Costentin, Charlotte E., Gueorguieva, Ivelina, Smith, Claire, Cleverly, Ann, Lahn, Michael M., Raymond, Eric, Benhadji, Karim A., Giannelli, Gianluigi

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Clinical development of galunisertib (LY2157299 monohydrate), a small molecule inhibitor of transforming growth factor-beta signaling pathway von Herbertz, Stephan, Sawyer, J Scott, Stauber, Anja J, Gueorguieva, Ivelina, Driscoll, Kyla E, Estrem, Shawn T, Cleverly, Ann L, Desaiah, Durisala, Guba, Susan C, Benhadji, Karim A, Slapak, Christopher A, Lahn, Michael M

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Biomarkers and overall survival in patients with advanced hepatocellular carcinoma treated with TGF-βRI inhibitor galunisertib von Giannelli, Gianluigi, Santoro, Armando, Kelley, Robin K, Gane, Ed, Paradis, Valerie, Cleverly, Ann, Smith, Claire, Estrem, Shawn T, Man, Michael, Wang, Shuaicheng, Lahn, Michael M, Raymond, Eric, Benhadji, Karim A, Faivre, Sandrine

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Safety and activity of the TGFβ receptor I kinase inhibitor galunisertib plus the anti-PD-L1 antibody durvalumab in metastatic pancreatic cancer von Melisi, Davide, Oh, Do-Youn, Hollebecque, Antoine, Calvo, Emiliano, Varghese, Anna, Borazanci, Erkut, Macarulla, Teresa, Merz, Valeria, Zecchetto, Camilla, Zhao, Yumin, Gueorguieva, Ivelina, Man, Michael, Gandhi, Leena, Estrem, Shawn T, Benhadji, Karim A, Lanasa, Mark C, Avsar, Emin, Guba, Susan C, Garcia-Carbonero, Rocio

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Targeting the TGFβ pathway with galunisertib, a TGFβRI small molecule inhibitor, promotes anti-tumor immunity leading to durable, complete responses, as monotherapy and in combinat... von Holmgaard, Rikke B, Schaer, David A, Li, Yanxia, Castaneda, Stephen P, Murphy, Mary Y, Xu, Xiaohong, Inigo, Ivan, Dobkin, Julie, Manro, Jason R, Iversen, Philip W, Surguladze, David, Hall, Gerald E, Novosiadly, Ruslan D, Benhadji, Karim A, Plowman, Gregory D, Kalos, Michael, Driscoll, Kyla E

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A phase Ib/II study of galunisertib in combination with nivolumab in solid tumors and non-small cell lung cancer von Nadal, Ernest, Saleh, Mansoor, Aix, Santiago Ponce, Ochoa-de-Olza, Maria, Patel, Sandip Pravin, Antonia, Scott, Zhao, Yumin, Gueorguieva, Ivelina, Man, Michael, Estrem, Shawn T, Liu, Jiangang, Avsar, Emin, Lin, Wen Hong, Benhadji, Karim A, Gandhi, Leena, Guba, Susan C, Diaz, Inmaculada Ales

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Body weight loss as a prognostic and predictive factor in previously treated patients with metastatic gastric cancer: post hoc analyses of the randomized phase III TAGS trial von Ghidini, Michele, Hochster, Howard, Doi, Toshihiko, Van Cutsem, Eric, Makris, Lukas, Takahashi, Osamu, Benhadji, Karim A., Mansoor, Wasat

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Evaluation of the effects of an oral notch inhibitor, crenigacestat (LY3039478), on QT interval, and bioavailability studies conducted in healthy subjects von Yuen, Eunice, Posada, Maria, Smith, Claire, Thorn, Katharine, Greenwood, Dale, Burgess, Michelle, A. Benhadji, Karim, Ortega, Demetrio, Chinchen, Louise, Suico, Jeffrey

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Correction: Biomarkers and overall survival in patients with advanced hepatocellular carcinoma treated with TGF-βRI inhibitor galunisertib von Giannelli, Gianluigi, Santoro, Armando, Kelley, Robin K., Gane, Ed, Paradis, Valerie, Cleverly, Ann, Smith, Claire, Estrem, Shawn T., Man, Michael, Wang, Shuaicheng, Lahn, Michael M., Raymond, Eric, Benhadji, Karim A., Faivre, Sandrine

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Efficacy and safety of trifluridine/tipiracil in older and younger patients with metastatic gastric or gastroesophageal junction cancer: subgroup analysis of a randomized phase 3 s... von Shitara, Kohei, Doi, Toshihiko, Hosaka, Hisashi, Thuss-Patience, Peter, Santoro, Armando, Longo, Federico, Ozyilkan, Ozgur, Cicin, Irfan, Park, David, Zaanan, Aziz, Pericay, Carles, Özgüroğlu, Mustafa, Alsina, Maria, Makris, Lukas, Benhadji, Karim A., Ilson, David H.

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Phase 1b study of galunisertib and ramucirumab in patients with advanced hepatocellular carcinoma von Harding, James J., Do, Richard K., Yaqubie, Amin, Cleverly, Ann, Zhao, Yumin, Gueorguieva, Ivelina, Lahn, Michael, Benhadji, Karim A., Kelley, Robin K., Abou‐Alfa, Ghassan K.

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Futibatinib, an Irreversible FGFR1-4 Inhibitor, in Patients with Advanced Solid Tumors Harboring FGF / FGFR Aberrations: A Phase I Dose-Expansion Study von Meric-Bernstam, Funda, Bahleda, Rastislav, Hierro, Cinta, Sanson, Marc, Bridgewater, John, Arkenau, Hendrik-Tobias, Tran, Ben, Kelley, Robin Kate, Park, Joon Oh, Javle, Milind, He, Yaohua, Benhadji, Karim A, Goyal, Lipika

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Trifluridine/tipiracil in patients with metastatic gastroesophageal junction cancer: a subgroup analysis from the phase 3 TAGS study von Mansoor, Wasat, Arkenau, Hendrik-Tobias, Alsina, Maria, Shitara, Kohei, Thuss-Patience, Peter, Cuffe, Sinead, Dvorkin, Mikhail, Park, David, Ando, Takayuki, Van Den Eynde, Marc, Beretta, Giordano D., Zaniboni, Alberto, Doi, Toshihiko, Tabernero, Josep, Ilson, David H., Makris, Lukas, Benhadji, Karim A., Van Cutsem, Eric

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Trifluridine–Tipiracil and Bevacizumab in Refractory Metastatic Colorectal Cancer von Prager, Gerald W., Taieb, Julien, Fakih, Marwan, Ciardiello, Fortunato, Van Cutsem, Eric, Elez, Elena, Cruz, Felipe M., Wyrwicz, Lucjan, Stroyakovskiy, Daniil, Pápai, Zsuzsanna, Poureau, Pierre-Guillaume, Liposits, Gabor, Cremolini, Chiara, Bondarenko, Igor, Modest, Dominik P., Benhadji, Karim A., Amellal, Nadia, Leger, Catherine, Vidot, Loïck, Tabernero, Josep

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Galunisertib plus gemcitabine vs. gemcitabine for first-line treatment of patients with unresectable pancreatic cancer von Melisi, Davide, Garcia-Carbonero, Rocio, Macarulla, Teresa, Pezet, Denis, Deplanque, Gael, Fuchs, Martin, Trojan, Jorg, Oettle, Helmut, Kozloff, Mark, Cleverly, Ann, Smith, Claire, Estrem, Shawn T., Gueorguieva, Ivelina, Lahn, Michael M. F., Blunt, Al, Benhadji, Karim A., Tabernero, Josep

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Futibatinib for FGFR2-Rearranged Intrahepatic Cholangiocarcinoma von Goyal, Lipika, Meric-Bernstam, Funda, Hollebecque, Antoine, Valle, Juan W., Morizane, Chigusa, Karasic, Thomas B., Abrams, Thomas A., Furuse, Junji, Kelley, Robin K., Cassier, Philippe A., Klümpen, Heinz-Josef, Chang, Heung-Moon, Chen, Li-Tzong, Tabernero, Josep, Oh, Do-Youn, Mahipal, Amit, Moehler, Markus, Mitchell, Edith P., Komatsu, Yoshito, Masuda, Kunihiro, Ahn, Daniel, Epstein, Robert S., Halim, Abdel-Baset, Fu, Yao, Salimi, Tehseen, Wacheck, Volker, He, Yaohua, Liu, Mei, Benhadji, Karim A., Bridgewater, John A.

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Effects of protein kinase C modulation by PEP005, a novel ingenol angelate, on mitogen-activated protein kinase and phosphatidylinositol 3-kinase signaling in cancer cells von Serova, Maria, Ghoul, Aïda, Benhadji, Karim A, Faivre, Sandrine, Le Tourneau, Christophe, Cvitkovic, Esteban, Lokiec, Francois, Lord, Janet, Ogbourne, Steven M, Calvo, Fabien, Raymond, Eric

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Epithelial-to-mesenchymal transition and resistance to ingenol 3-angelate, a novel protein kinase C modulator, in colon cancer cells von Ghoul, Aïda, Serova, Maria, Astorgues-Xerri, Lucile, Bieche, Ivan, Bousquet, Guilhem, Varna, Mariana, Vidaud, Michel, Phillips, Edelmira, Weill, Sophie, Benhadji, Karim A, Lokiec, François, Cvitkovic, Esteban, Faivre, Sandrine, Raymond, Eric

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Phase 1 study to evaluate Crenigacestat (LY3039478) in combination with dexamethasone in patients with T‐cell acute lymphoblastic leukemia and lymphoma von Borthakur, Gautam, Martinelli, Giovanni, Raffoux, Emmanuel, Chevallier, Patrice, Chromik, Jörg, Lithio, Andrew, Smith, Claire L., Yuen, Eunice, Oakley, Gerard Joseph, Benhadji, Karim A., DeAngelo, Daniel J.

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TGFβ receptor inhibitor galunisertib is linked to inflammation- and remodeling-related proteins in patients with pancreatic cancer von Melisi, Davide, Garcia-Carbonero, Rocio, Macarulla, Teresa, Pezet, Denis, Deplanque, Gael, Fuchs, Martin, Trojan, Jorg, Kozloff, Mark, Simionato, Francesca, Cleverly, Ann, Smith, Claire, Wang, Shuaicheng, Man, Michael, Driscoll, Kyla E., Estrem, Shawn T., Lahn, Michael M. F., Benhadji, Karim A., Tabernero, Josep

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