Mutant IDH inhibits HNF-4α to block hepatocyte differentiation and promote biliary cancer von Saha, Supriya K., Parachoniak, Christine A., Ghanta, Krishna S., Fitamant, Julien, Ross, Kenneth N., Najem, Mortada S., Gurumurthy, Sushma, Akbay, Esra A., Sia, Daniela, Cornella, Helena, Miltiadous, Oriana, Walesky, Chad, Deshpande, Vikram, Zhu, Andrew X., Hezel, Aram F., Yen, Katharine E., Straley, Kimberly S., Travins, Jeremy, Popovici-Muller, Janeta, Gliser, Camelia, Ferrone, Cristina R., Apte, Udayan, Llovet, Josep M., Wong, Kwok-Kin, Ramaswamy, Sridhar, Bardeesy, Nabeel

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Genetics of Biliary Tract Cancers and Emerging Targeted Therapies von HEZEL, Aram F, DESHPANDE, Vikram, ZHU, Andrew X

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Kras and Tp53 Mutations Cause Cholangiocyte- and Hepatocyte-Derived Cholangiocarcinoma von Hill, Margaret A, Alexander, William B, Guo, Bing, Kato, Yasutaka, Patra, Krushna, O'Dell, Michael R, McCall, Matthew N, Whitney-Miller, Christa L, Bardeesy, Nabeel, Hezel, Aram F

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Genetics and biology of pancreatic ductal adenocarcinoma von Hezel, Aram F, Kimmelman, Alec C, Stanger, Ben Z, Bardeesy, Nabeel, Depinho, Ronald A

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Oncogenic Kras Maintains Pancreatic Tumors through Regulation of Anabolic Glucose Metabolism von Ying, Haoqiang, Kimmelman, Alec C., Lyssiotis, Costas A., Hua, Sujun, Chu, Gerald C., Fletcher-Sananikone, Eliot, Locasale, Jason W., Son, Jaekyoung, Zhang, Hailei, Coloff, Jonathan L., Yan, Haiyan, Wang, Wei, Chen, Shujuan, Viale, Andrea, Zheng, Hongwu, Paik, Ji-hye, Lim, Carol, Guimaraes, Alexander R., Martin, Eric S., Chang, Jeffery, Hezel, Aram F., Perry, Samuel R., Hu, Jian, Gan, Boyi, Xiao, Yonghong, Asara, John M., Weissleder, Ralph, Wang, Y. Alan, Chin, Lynda, Cantley, Lewis C., DePinho, Ronald A.

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Current Management of Gallbladder Carcinoma von Zhu, Andrew X., Hong, Theodore S., Hezel, Aram F., Kooby, David A.

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ARID1A, a SWI/SNF subunit, is critical to acinar cell homeostasis and regeneration and is a barrier to transformation and epithelial-mesenchymal transition in the pancreas von Wang, Wenjia, Friedland, Scott C, Guo, Bing, O’Dell, Michael R, Alexander, William B, Whitney-Miller, Christa L, Agostini-Vulaj, Diana, Huber, Aaron R, Myers, Jason R, Ashton, John M, Dunne, Richard F, Steiner, Laurie A, Hezel, Aram F

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Frequent Mutation of Isocitrate Dehydrogenase (IDH)1 and IDH2 in Cholangiocarcinoma Identified Through Broad‐Based Tumor Genotyping von Borger, Darrell R., Tanabe, Kenneth K., Fan, Kenneth C., Lopez, Hector U., Fantin, Valeria R., Straley, Kimberly S., Schenkein, David P., Hezel, Aram F., Ancukiewicz, Marek, Liebman, Hannah M., Kwak, Eunice L., Clark, Jeffrey W., Ryan, David P., Deshpande, Vikram, Dias‐Santagata, Dora, Ellisen, Leif W., Zhu, Andrew X., Iafrate, A. John

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Systemic Therapy for Biliary Tract Cancers von Hezel, Aram F., Zhu, Andrew X.

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Stereotactic Hypofractionated Radiation Therapy as a Bridge to Transplantation for Hepatocellular Carcinoma: Clinical Outcome and Pathologic Correlation von Katz, Alan W., M.D., M.P.H, Chawla, Sheema, M.D, Qu, Zhenhong, M.D., Ph.D, Kashyap, Randeep, M.D, Milano, Michael T., M.D., Ph.D, Hezel, Aram F., M.D

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Liprin-α3 controls vesicle docking and exocytosis at the active zone of hippocampal synapses von Wong, Man Yan, Liu, Changliang, Wang, Shan Shan H., Roquas, Aram C. F., Fowler, Stephen C., Kaeser, Pascal S.

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Beyond microsatellite testing: assessment of tumor mutational burden identifies subsets of colorectal cancer who may respond to immune checkpoint inhibition von Fabrizio, David A, George, Jr, Thomas J, Dunne, Richard F, Frampton, Garrett, Sun, James, Gowen, Kyle, Kennedy, Mark, Greenbowe, Joel, Schrock, Alexa B, Hezel, Aram F, Ross, Jeffrey S, Stephens, Phillip J, Ali, Siraj M, Miller, Vincent A, Fakih, Marwan, Klempner, Samuel J

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Combined MEK and PI3K inhibition in a mouse model of pancreatic cancer von Alagesan, Brinda, Contino, Gianmarco, Guimaraes, Alex R, Corcoran, Ryan B, Deshpande, Vikram, Wojtkiewicz, Gregory R, Hezel, Aram F, Wong, Kwok-Kin, Loda, Massimo, Weissleder, Ralph, Benes, Cyril H, Engelman, Jeffrey, Bardeesy, Nabeel

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Stromal biology of pancreatic cancer von Chu, Gerald C., Kimmelman, Alec C., Hezel, Aram F., DePinho, Ronald A.

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Smad4 is dispensable for normal pancreas development yet critical in progression and tumor biology of pancreas cancer von Bardeesy, Nabeel, Cheng, Kuang-Hung, Berger, Justin H, Chu, Gerald C, Pahler, Jessica, Olson, Peter, Hezel, Aram F, Horner, James, Lauwers, Gregory Y, Hanahan, Douglas, DePinho, Ronald A

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Efficacy, Safety, and Potential Biomarkers of Sunitinib Monotherapy in Advanced Hepatocellular Carcinoma: A Phase II Study von ZHU, Andrew X, SAHANI, Dushyant V, BHARGAVA, Pankaj, MEYERHARDT, Jeffrey, CLARK, Jeffrey W, KWAK, Eunice L, HEZEL, Aram F, MIKSAD, Rebecca, ABRAMS, Thomas A, ENZINGER, Peter C, FUCHS, Charles S, RYAN, David P, DUDA, Dan G, JAIN, Rakesh K, DI TOMASO, Emmanuelle, ANCUKIEWICZ, Marek, CATALANO, Onofrio A, SINDHWANI, Vivek, BLASZKOWSKY, Lawrence S, YOON, Sam S, LAHDENRANTA, Johanna

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Plac8 Links Oncogenic Mutations to Regulation of Autophagy and Is Critical to Pancreatic Cancer Progression von Kinsey, Conan, Balakrishnan, Vijaya, O’Dell, Michael R., Huang, Jing Li, Newman, Laurel, Whitney-Miller, Christa L., Hezel, Aram F., Land, Hartmut

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Development of molecularly targeted therapies in biliary tract cancers: Reassessing the challenges and opportunities von Zhu, Andrew X., Hezel, Aram F.

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Endocrine-Exocrine Signaling Drives Obesity-Associated Pancreatic Ductal Adenocarcinoma von Chung, Katherine Minjee, Singh, Jaffarguriqbal, Lawres, Lauren, Dorans, Kimberly Judith, Garcia, Cathy, Burkhardt, Daniel B., Robbins, Rebecca, Bhutkar, Arjun, Cardone, Rebecca, Zhao, Xiaojian, Babic, Ana, Vayrynen, Sara A., Dias Costa, Andressa, Nowak, Jonathan A., Chang, Daniel T., Dunne, Richard F., Hezel, Aram F., Koong, Albert C., Wilhelm, Joshua J., Bellin, Melena D., Nylander, Vibe, Gloyn, Anna L., McCarthy, Mark I., Kibbey, Richard G., Krishnaswamy, Smita, Wolpin, Brian M., Jacks, Tyler, Fuchs, Charles S., Muzumdar, Mandar Deepak

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Composition, Spatial Characteristics, and Prognostic Significance of Myeloid Cell Infiltration in Pancreatic Cancer von Väyrynen, Sara A, Zhang, Jinming, Yuan, Chen, Väyrynen, Juha P, Dias Costa, Andressa, Williams, Hannah, Morales-Oyarvide, Vicente, Lau, Mai Chan, Rubinson, Douglas A, Dunne, Richard F, Kozak, Margaret M, Wang, Wenjia, Agostini-Vulaj, Diana, Drage, Michael G, Brais, Lauren, Reilly, Emma, Rahma, Osama, Clancy, Thomas, Wang, Jiping, Linehan, David C, Aguirre, Andrew J, Fuchs, Charles S, Coussens, Lisa M, Chang, Daniel T, Koong, Albert C, Hezel, Aram F, Ogino, Shuji, Nowak, Jonathan A, Wolpin, Brian M

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