スパコン「京」によるインシリコ創薬 von 中津井, 雅彦, 鎌田, 真由美, 荒木, 望嗣, 奥野, 恭史

Volltext

臨床ビッグデータ解析の展望—実臨床データとゲノム情報への応用 von 内野, 詠一郎, 種石, 慶, 中津井, 雅彦, 鎌田, 真由美, 荒木, 望嗣, 奥野, 恭史

Volltext

Brigatinib combined with anti-EGFR antibody overcomes osimertinib resistance in EGFR-mutated non-small-cell lung cancer von Uchibori, Ken, Inase, Naohiko, Araki, Mitsugu, Kamada, Mayumi, Sato, Shigeo, Okuno, Yasushi, Fujita, Naoya, Katayama, Ryohei

Volltext

Calculation of absolute binding free energies between the hERG channel and structurally diverse drugs von Negami, Tatsuki, Araki, Mitsugu, Okuno, Yasushi, Terada, Tohru

Volltext

A secondary RET mutation in the activation loop conferring resistance to vandetanib von Nakaoku, Takashi, Kohno, Takashi, Araki, Mitsugu, Niho, Seiji, Chauhan, Rakhee, Knowles, Phillip P., Tsuchihara, Katsuya, Matsumoto, Shingo, Shimada, Yoko, Mimaki, Sachiyo, Ishii, Genichiro, Ichikawa, Hitoshi, Nagatoishi, Satoru, Tsumoto, Kouhei, Okuno, Yasushi, Yoh, Kiyotaka, McDonald, Neil Q., Goto, Koichi

Volltext

Exploring ligand binding pathways on proteins using hypersound-accelerated molecular dynamics von Araki, Mitsugu, Matsumoto, Shigeyuki, Bekker, Gert-Jan, Isaka, Yuta, Sagae, Yukari, Kamiya, Narutoshi, Okuno, Yasushi

Volltext

Molecular dynamics simulation-guided drug sensitivity prediction for lung cancer with rare EGFR mutations von Ikemura, Shinnosuke, Yasuda, Hiroyuki, Matsumoto, Shingo, Kamada, Mayumi, Hamamoto, Junko, Masuzawa, Keita, Kobayashi, Keigo, Manabe, Tadashi, Arai, Daisuke, Nakachi, Ichiro, Kawada, Ichiro, Ishioka, Kota, Nakamura, Morio, Namkoong, Ho, Naoki, Katsuhiko, Ono, Fumie, Araki, Mitsugu, Kanada, Ryo, Ma, Biao, Hayashi, Yuichiro, Mimaki, Sachiyo, Yoh, Kiyotaka, Kobayashi, Susumu S., Kohno, Takashi, Okuno, Yasushi, Goto, Koichi, Tsuchihara, Katsuya, Soejima, Kenzo

Volltext

SY4-4. LTK融合遺伝子陽性肺癌に対するロルラチニブの耐性機序とその克服 von 泉大樹, 森俊太, 香川洋輔, 松本慎吾, 荒木望嗣, 柴田祐司, 酒井徹也, 野崎要, 善家義貴, 葉清隆, 奥野恭史, 後藤功一, 小林進

Volltext

Novel Calcium-Binding Ablating Mutations Induce Constitutive RET Activity and Drive Tumorigenesis von Tabata, Junya, Nakaoku, Takashi, Araki, Mitsugu, Yoshino, Ryunosuke, Kohsaka, Shinji, Otsuka, Ayaka, Ikegami, Masachika, Ui, Ayako, Kanno, Shin-Ichiro, Miyoshi, Keiko, Matsumoto, Shigeyuki, Sagae, Yukari, Yasui, Akira, Sekijima, Masakazu, Mano, Hiroyuki, Okuno, Yasushi, Okamoto, Aikou, Kohno, Takashi

Volltext

Hydrophobic interactions at subsite S1′ of human dipeptidyl peptidase IV contribute significantly to the inhibitory effect of tripeptides von Araki, Mitsugu, Kanegawa, Norimasa, Iwata, Hiroaki, Sagae, Yukari, Ito, Keisuke, Masuda, Katsuyoshi, Okuno, Yasushi

Volltext