Computationally efficient whole-genome regression for quantitative and binary traits von Mbatchou, Joelle, Barnard, Leland, Backman, Joshua, Marcketta, Anthony, Kosmicki, Jack A., Ziyatdinov, Andrey, Benner, Christian, O’Dushlaine, Colm, Barber, Mathew, Boutkov, Boris, Habegger, Lukas, Ferreira, Manuel, Baras, Aris, Reid, Jeffrey, Abecasis, Goncalo, Maxwell, Evan, Marchini, Jonathan

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Inactivating Variants in ANGPTL4 and Risk of Coronary Artery Disease von Dewey, Frederick E, Gusarova, Viktoria, O’Dushlaine, Colm, Gottesman, Omri, Trejos, Jesus, Hunt, Charleen, Van Hout, Cristopher V, Habegger, Lukas, Buckler, David, Lai, Ka-Man V, Leader, Joseph B, Murray, Michael F, Ritchie, Marylyn D, Kirchner, H. Lester, Ledbetter, David H, Penn, John, Lopez, Alexander, Borecki, Ingrid B, Overton, John D, Reid, Jeffrey G, Carey, David J, Murphy, Andrew J, Yancopoulos, George D, Baras, Aris, Gromada, Jesper, Shuldiner, Alan R

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Genetic identification of familial hypercholesterolemia within a single U.S. health care system von Abul-Husn, Noura S., Manickam, Kandamurugu, Jones, Laney K., Wright, Eric A., Hartzel, Dustin N., Gonzaga-Jauregui, Claudia, O'Dushlaine, Colm, Leader, Joseph B., Kirchner, H. Lester, Lindbuchler, D'Andra M., Barr, Marci L., Giovanni, Monica A., Ritchie, Marylyn D., Overton, John D., Reid, Jeffrey G., Metpally, Raghu P. R., Wardeh, Amr H., Borecki, Ingrid B., Yancopoulos, George D., Baras, Aris, Shuldiner, Alan R., Gottesman, Omri, Ledbetter, David H., Carey, David J., Dewey, Frederick E., Murray, Michael F.

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A Protein-Truncating HSD17B13 Variant and Protection from Chronic Liver Disease von Abul-Husn, Noura S, Cheng, Xiping, Li, Alexander H, Xin, Yurong, Schurmann, Claudia, Stevis, Panayiotis, Liu, Yashu, Kozlitina, Julia, Stender, Stefan, Wood, G. Craig, Stepanchick, Ann N, Still, Matthew D, McCarthy, Shane, O’Dushlaine, Colm, Packer, Jonathan S, Balasubramanian, Suganthi, Gosalia, Nehal, Esopi, David, Kim, Sun Y, Mukherjee, Semanti, Lopez, Alexander E, Fuller, Erin D, Penn, John, Chu, Xin, Luo, Jonathan Z, Mirshahi, Uyenlinh L, Carey, David J, Still, Christopher D, Feldman, Michael D, Small, Aeron, Damrauer, Scott M, Rader, Daniel J, Zambrowicz, Brian, Olson, William, Murphy, Andrew J, Borecki, Ingrid B, Shuldiner, Alan R, Reid, Jeffrey G, Overton, John D, Yancopoulos, George D, Hobbs, Helen H, Cohen, Jonathan C, Gottesman, Omri, Teslovich, Tanya M, Baras, Aris, Mirshahi, Tooraj, Gromada, Jesper, Dewey, Frederick E

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Exome sequencing and characterization of 49,960 individuals in the UK Biobank von Van Hout, Cristopher V., Tachmazidou, Ioanna, Backman, Joshua D., Hoffman, Joshua D., Liu, Daren, Pandey, Ashutosh K., Gonzaga-Jauregui, Claudia, Khalid, Shareef, Ye, Bin, Banerjee, Nilanjana, Li, Alexander H., O’Dushlaine, Colm, Marcketta, Anthony, Staples, Jeffrey, Schurmann, Claudia, Hawes, Alicia, Maxwell, Evan, Barnard, Leland, Lopez, Alexander, Penn, John, Habegger, Lukas, Blumenfeld, Andrew L., Bai, Xiaodong, O’Keeffe, Sean, Yadav, Ashish, Praveen, Kavita, Jones, Marcus, Salerno, William J., Chung, Wendy K., Surakka, Ida, Willer, Cristen J., Hveem, Kristian, Leader, Joseph B., Carey, David J., Ledbetter, David H., Cardon, Lon, Yancopoulos, George D., Economides, Aris, Coppola, Giovanni, Shuldiner, Alan R., Balasubramanian, Suganthi, Cantor, Michael, Nelson, Matthew R., Whittaker, John, Reid, Jeffrey G., Marchini, Jonathan, Overton, John D., Scott, Robert A., Abecasis, Gonçalo R., Yerges-Armstrong, Laura, Baras, Aris

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Biobank-driven genomic discovery yields new insight into atrial fibrillation biology von Nielsen, Jonas B., Thorolfsdottir, Rosa B., Fritsche, Lars G., Zhou, Wei, Skov, Morten W., Graham, Sarah E., Herron, Todd J., McCarthy, Shane, Schmidt, Ellen M., Sveinbjornsson, Gardar, Surakka, Ida, Mathis, Michael R., Yamazaki, Masatoshi, Crawford, Ryan D., Gabrielsen, Maiken E., Skogholt, Anne Heidi, Holmen, Oddgeir L., Lin, Maoxuan, Wolford, Brooke N., Dey, Rounak, Dalen, Håvard, Sulem, Patrick, Chung, Jonathan H., Backman, Joshua D., Arnar, David O., Thorsteinsdottir, Unnur, Baras, Aris, O’Dushlaine, Colm, Holst, Anders G., Wen, Xiaoquan, Hornsby, Whitney, Dewey, Frederick E., Boehnke, Michael, Kheterpal, Sachin, Mukherjee, Bhramar, Lee, Seunggeun, Kang, Hyun M., Holm, Hilma, Kitzman, Jacob, Shavit, Jordan A., Jalife, José, Brummett, Chad M., Teslovich, Tanya M., Carey, David J., Gudbjartsson, Daniel F., Stefansson, Kari, Abecasis, Gonçalo R., Hveem, Kristian, Willer, Cristen J.

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A polygenic burden of rare disruptive mutations in schizophrenia von Purcell, Shaun M., Moran, Jennifer L., Fromer, Menachem, Ruderfer, Douglas, Solovieff, Nadia, Roussos, Panos, O’Dushlaine, Colm, Chambert, Kimberly, Bergen, Sarah E., Kähler, Anna, Duncan, Laramie, Stahl, Eli, Genovese, Giulio, Fernández, Esperanza, Collins, Mark O., Komiyama, Noboru H., Choudhary, Jyoti S., Magnusson, Patrik K. E., Banks, Eric, Shakir, Khalid, Garimella, Kiran, Fennell, Tim, DePristo, Mark, Grant, Seth G. N., Haggarty, Stephen J., Gabriel, Stacey, Scolnick, Edward M., Lander, Eric S., Hultman, Christina M., Sullivan, Patrick F., McCarroll, Steven A., Sklar, Pamela

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INRICH: interval-based enrichment analysis for genome-wide association studies von LEE, Phil H, O'DUSHLAINE, Colm, THOMAS, Brett, PURCELL, Shaun M

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Genome-wide analysis provides genetic evidence that ACE2 influences COVID-19 risk and yields risk scores associated with severe disease von Horowitz, Julie E., Kosmicki, Jack A., Damask, Amy, Sharma, Deepika, Roberts, Genevieve H. L., Justice, Anne E., Banerjee, Nilanjana, Coignet, Marie V., Yadav, Ashish, Leader, Joseph B., Marcketta, Anthony, Park, Danny S., Lanche, Rouel, Maxwell, Evan, Knight, Spencer C., Bai, Xiaodong, Guturu, Harendra, Sun, Dylan, Baltzell, Asher, Kury, Fabricio S. P., Backman, Joshua D., Girshick, Ahna R., O’Dushlaine, Colm, McCurdy, Shannon R., Partha, Raghavendran, Mansfield, Adam J., Turissini, David A., Li, Alexander H., Zhang, Miao, Mbatchou, Joelle, Watanabe, Kyoko, Gurski, Lauren, McCarthy, Shane E., Kang, Hyun M., Dobbyn, Lee, Stahl, Eli, Verma, Anurag, Sirugo, Giorgio, Ritchie, Marylyn D., Jones, Marcus, Balasubramanian, Suganthi, Siminovitch, Katherine, Salerno, William J., Shuldiner, Alan R., Rader, Daniel J., Mirshahi, Tooraj, Locke, Adam E., Marchini, Jonathan, Overton, John D., Carey, David J., Habegger, Lukas, Cantor, Michael N., Rand, Kristin A., Hong, Eurie L., Reid, Jeffrey G., Ball, Catherine A., Baras, Aris, Abecasis, Gonçalo R., Ferreira, Manuel A. R.

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Distribution and clinical impact of functional variants in 50,726 whole-exome sequences from the DiscovEHR Study von Dewey, Frederick E.

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zCall: a rare variant caller for array-based genotyping von GOLDSTEIN, Jacqueline I, CRENSHAW, Andrew, SCHIZOPHRENIA CONSORTIUM, Swedish, SEQUENCING CONSORTIUM, Arra Autism, SKLAR, Pamela, HULTMAN, Christina M, PURCELL, Shaun, MCCARROLL, Steven A, SULLIVAN, Patrick F, DALY, Mark J, NEALE, Benjamin M, CAREY, Jason, GRANT, George B, MAGUIRE, Jared, FROMER, Menachem, O'DUSHLAINE, Colm, MORAN, Jennifer L, CHAMBERT, Kimberly, STEVENS, Christine

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Schizophrenia is Associated With an Aberrant Immune Response to Epstein-Barr Virus von Dickerson, Faith, Jones-Brando, Lorraine, Ford, Glen, Genovese, Giulio, Stallings, Cassie, Origoni, Andrea, O'Dushlaine, Colm, Katsafanas, Emily, Sweeney, Kevin, Khushalani, Sunil, Yolken, Robert

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Whole-genome analysis of human embryonic stem cells enables rational line selection based on genetic variation von Merkle, Florian T., Ghosh, Sulagna, Genovese, Giulio, Handsaker, Robert E., Kashin, Seva, Meyer, Daniel, Karczewski, Konrad J., O’Dushlaine, Colm, Pato, Carlos, Pato, Michele, MacArthur, Daniel G., McCarroll, Steven A., Eggan, Kevin

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Integrating evolutionary and regulatory information with a multispecies approach implicates genes and pathways in obsessive-compulsive disorder von Noh, Hyun Ji, Tang, Ruqi, Flannick, Jason, O’Dushlaine, Colm, Swofford, Ross, Howrigan, Daniel, Genereux, Diane P., Johnson, Jeremy, van Grootheest, Gerard, Grünblatt, Edna, Andersson, Erik, Djurfeldt, Diana R., Patel, Paresh D., Koltookian, Michele, M. Hultman, Christina, Pato, Michele T., Pato, Carlos N., Rasmussen, Steven A., Jenike, Michael A., Hanna, Gregory L., Stewart, S. Evelyn, Knowles, James A., Ruhrmann, Stephan, Grabe, Hans-Jörgen, Wagner, Michael, Rück, Christian, Mathews, Carol A., Walitza, Susanne, Cath, Daniëlle C., Feng, Guoping, Karlsson, Elinor K., Lindblad-Toh, Kerstin

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Pan-ancestry exome-wide association analyses of COVID-19 outcomes in 586,157 individuals von Kosmicki, Jack A., Horowitz, Julie E., Banerjee, Nilanjana, Lanche, Rouel, Marcketta, Anthony, Maxwell, Evan, Bai, Xiaodong, Sun, Dylan, Backman, Joshua D., Sharma, Deepika, Kury, Fabricio S.P., Kang, Hyun M., O’Dushlaine, Colm, Yadav, Ashish, Mansfield, Adam J., Li, Alexander H., Watanabe, Kyoko, Gurski, Lauren, McCarthy, Shane E., Locke, Adam E., Khalid, Shareef, O’Keeffe, Sean, Mbatchou, Joelle, Chazara, Olympe, Huang, Yunfeng, Kvikstad, Erika, O’Neill, Amanda, Nioi, Paul, Parker, Meg M., Petrovski, Slavé, Runz, Heiko, Szustakowski, Joseph D., Wang, Quanli, Wong, Emily, Cordova-Palomera, Aldo, Smith, Erin N., Szalma, Sandor, Zheng, Xiuwen, Esmaeeli, Sahar, Davis, Justin W., Lai, Yi-Pin, Chen, Xing, Justice, Anne E., Leader, Joseph B., Mirshahi, Tooraj, Carey, David J., Verma, Anurag, Sirugo, Giorgio, Ritchie, Marylyn D., Rader, Daniel J., Povysil, Gundula, Goldstein, David B., Kiryluk, Krzysztof, Pairo-Castineira, Erola, Rawlik, Konrad, Pasko, Dorota, Walker, Susan, Meynert, Alison, Kousathanas, Athanasios, Moutsianas, Loukas, Tenesa, Albert, Caulfield, Mark, Scott, Richard, Wilson, James F., Baillie, J. Kenneth, Butler-Laporte, Guillaume, Nakanishi, Tomoko, Lathrop, Mark, Richards, J. Brent, Jones, Marcus, Balasubramanian, Suganthi, Salerno, William, Shuldiner, Alan R., Marchini, Jonathan, Overton, John D., Habegger, Lukas, Cantor, Michael N., Reid, Jeffrey G., Baras, Aris, Abecasis, Goncalo R., Ferreira, Manuel A.R.

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Pathway analyses implicate glial cells in schizophrenia von Duncan, Laramie E, Holmans, Peter A, Lee, Phil H, O'Dushlaine, Colm T, Kirby, Andrew W, Smoller, Jordan W, Öngür, Dost, Cohen, Bruce M

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An allelic-series rare-variant association test for candidate-gene discovery von McCaw, Zachary R., O’Dushlaine, Colm, Somineni, Hari, Bereket, Michael, Klein, Christoph, Karaletsos, Theofanis, Casale, Francesco Paolo, Koller, Daphne, Soare, Thomas W.

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Reciprocal Duplication of the Williams-Beuren Syndrome Deletion on Chromosome 7q11.23 Is Associated with Schizophrenia von Mulle, Jennifer Gladys, Pulver, Ann E, McGrath, John A, Wolyniec, Paula S, Dodd, Anne F, Cutler, David J, Sebat, Jonathan, Malhotra, Dheeraj, Nestadt, Gerald, Conrad, Donald F, Hurles, Matthew, Barnes, Chris P, Ikeda, Masashi, Iwata, Nakao, Levinson, Douglas F, Gejman, Pablo V, Sanders, Alan R, Duan, Jubao, Mitchell, Adele A, Peter, Inga, Sklar, Pamela, O’Dushlaine, Colm T, Grozeva, Detelina, O’Donovan, Michael C, Owen, Michael J, Hultman, Christina M, Kähler, Anna K, Sullivan, Patrick F, Kirov, George, Warren, Stephen T

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Association of Rare and Common Variation in the Lipoprotein Lipase Gene With Coronary Artery Disease von Khera, Amit V, Won, Hong-Hee, Peloso, Gina M, O’Dushlaine, Colm, Liu, Dajiang, Stitziel, Nathan O, Natarajan, Pradeep, Nomura, Akihiro, Emdin, Connor A, Gupta, Namrata, Borecki, Ingrid B, Asselta, Rosanna, Duga, Stefano, Merlini, Piera Angelica, Correa, Adolfo, Kessler, Thorsten, Wilson, James G, Bown, Matthew J, Hall, Alistair S, Braund, Peter S, Carey, David J, Murray, Michael F, Kirchner, H. Lester, Leader, Joseph B, Lavage, Daniel R, Manus, J. Neil, Hartzel, Dustin N, Samani, Nilesh J, Schunkert, Heribert, Marrugat, Jaume, Elosua, Roberto, McPherson, Ruth, Farrall, Martin, Watkins, Hugh, Lander, Eric S, Rader, Daniel J, Danesh, John, Ardissino, Diego, Gabriel, Stacey, Willer, Cristen, Abecasis, Gonçalo R, Saleheen, Danish, Dewey, Frederick E, Kathiresan, Sekar

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Rare Copy Number Variation in Treatment-Resistant Major Depressive Disorder von O’Dushlaine, Colm, Ripke, Stephan, Ruderfer, Douglas M, Hamilton, Steven P, Fava, Maurizio, Iosifescu, Dan V, Kohane, Isaac S, Churchill, Susanne E, Castro, Victor M, Clements, Caitlin C, Blumenthal, Sarah R, Murphy, Shawn N, Smoller, Jordan W, Perlis, Roy H

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