Progranulin induces immune escape in breast cancer via up-regulating PD-L1 expression on tumor-associated macrophages (TAMs) and promoting CD8 + T cell exclusion von Fang, Wenli, Zhou, Ting, Shi, He, Yao, Mengli, Zhang, Dian, Qian, Husun, Zeng, Qian, Wang, Yange, Jin, Fangfang, Chai, Chengsen, Chen, Tingmei

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Targeted manipulation of the sortilin-progranulin axis rescues progranulin haploinsufficiency von Lee, Wing C, Almeida, Sandra, Prudencio, Mercedes, Caulfield, Thomas R, Zhang, Yong-Jie, Tay, William M, Bauer, Peter O, Chew, Jeannie, Sasaguri, Hiroki, Jansen-West, Karen R, Gendron, Tania F, Stetler, Caroline T, Finch, NiCole, Mackenzie, Ian R, Rademakers, Rosa, Gao, Fen-Biao, Petrucelli, Leonard

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Progranulin in neurodegenerative disease von Petkau, Terri L, Leavitt, Blair R

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Progranulin in neurodegenerative dementia von Wang, Xiao‐Ming, Zeng, Peng, Fang, Ying‐Yan, Zhang, Teng, Tian, Qing

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FTD-associated behavioural and transcriptomic abnormalities in ‘humanized’ progranulin-deficient mice: A novel model for progranulin-associated FTD von Life, Benjamin, Petkau, Terri L., Cruz, Giuliano N.F., Navarro-Delgado, Erick I., Shen, Ning, Korthauer, Keegan, Leavitt, Blair R.

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Effect of the Histone Deacetylase Inhibitor FRM-0334 on Progranulin Levels in Patients With Progranulin Gene Haploinsufficiency: A Randomized Clinical Trial von Ljubenkov, Peter A, Edwards, Lauren, Iaccarino, Leonardo, La Joie, Renaud, Rojas, Julio C, Koestler, Mary, Harris, Baruch, Boeve, Bradley F, Borroni, Barbara, van Swieten, John C, Grossman, Murray, Pasquier, Florence, Frisoni, Giovanni B, Mummery, Catherine J, Vandenberghe, Rik, Le Ber, Isabelle, Hannequin, Didier, McGinnis, Scott M, Auriacombe, Sophie, Onofrj, Marco, Goodman, Ira J, Riordan, Henry J, Wisniewski, Gary, Hesterman, Jacob, Marek, Ken, Haynes, Beth Ann, Patzke, Holger, Koenig, Gerhard, Hilt, Dana, Moebius, Hans, Boxer, Adam L

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Another piece in the progranulin puzzle: special binding between progranulin and prosaposin creates additional lysosomal access: An Editorial Comment for 'The interaction between progranulin and prosaposin is mediated by granulins and the linker region between saposin B and C' on page 236 von Van Damme, Philip

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Progranulin deficiency exaggerates, whereas progranulin-derived Atsttrin attenuates, severity of dermatitis in mice von Zhao, Yun-Peng, Tian, Qing-Yun, Liu, Chuan-Ju

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Progranulin: Functions and neurologic correlations von Townley, Ryan A, Boeve, Bradley F, Benarroch, Eduardo E

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The lysosomal function of progranulin, a guardian against neurodegeneration von Paushter, Daniel H., Du, Huan, Feng, Tuancheng, Hu, Fenghua

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Lysosomal processing of progranulin von Zhou, Xiaolai, Paushter, Daniel H, Feng, Tuancheng, Sun, Lirong, Reinheckel, Thomas, Hu, Fenghua

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Progranulin protects against amyloid β deposition and toxicity in Alzheimer's disease mouse models von Minami, S Sakura, Min, Sang-Won, Krabbe, Grietje, Wang, Chao, Zhou, Yungui, Asgarov, Rustam, Li, Yaqiao, Martens, Lauren H, Elia, Lisa P, Ward, Michael E, Mucke, Lennart, Farese, Robert V, Gan, Li

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Regulation of progranulin expression in human microglia and proteolysis of progranulin by matrix metalloproteinase-12 (MMP-12) von Suh, Hyeon-Sook, Choi, Namjong, Tarassishin, Leonid, Lee, Sunhee C

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Progranulin as a therapeutic target in neurodegenerative diseases von Rhinn, Herve, Tatton, Nadine, McCaughey, Stella, Kurnellas, Michael, Rosenthal, Arnon

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Progranulin: A key player in autoimmune diseases von Jian, Jinlong, Li, Guangfei, Hettinghouse, Aubryanna, Liu, Chuanju

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Neurotoxic microglia promote TDP-43 proteinopathy in progranulin deficiency von Zhang, Jiasheng, Velmeshev, Dmitry, Hashimoto, Kei, Huang, Yu-Hsin, Hofmann, Jeffrey W., Shi, Xiaoyu, Chen, Jiapei, Leidal, Andrew M., Dishart, Julian G., Cahill, Michelle K., Kelley, Kevin W., Liddelow, Shane A., Seeley, William W., Miller, Bruce L., Walther, Tobias C., Farese, Robert V., Taylor, J. Paul, Ullian, Erik M., Huang, Bo, Debnath, Jayanta, Wittmann, Torsten, Kriegstein, Arnold R., Huang, Eric J.

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Rescue of a lysosomal storage disorder caused by Grn loss of function with a brain penetrant progranulin biologic von Logan, Todd, Simon, Matthew J., Rana, Anil, Cherf, Gerald M., Srivastava, Ankita, Davis, Sonnet S., Low, Ray Lieh Yoon, Chiu, Chi-Lu, Fang, Meng, Huang, Fen, Bhalla, Akhil, Llapashtica, Ceyda, Prorok, Rachel, Pizzo, Michelle E., Calvert, Meredith E.K., Sun, Elizabeth W., Hsiao-Nakamoto, Jennifer, Rajendra, Yashas, Lexa, Katrina W., Srivastava, Devendra B., van Lengerich, Bettina, Wang, Junhua, Robles-Colmenares, Yaneth, Kim, Do Jin, Duque, Joseph, Lenser, Melina, Earr, Timothy K., Nguyen, Hoang, Chau, Roni, Tsogtbaatar, Buyankhishig, Ravi, Ritesh, Skuja, Lukas L., Solanoy, Hilda, Rosen, Howard J., Boeve, Bradley F., Boxer, Adam L., Heuer, Hilary W., Dennis, Mark S., Kariolis, Mihalis S., Monroe, Kathryn M., Przybyla, Laralynne, Sanchez, Pascal E., Meisner, Rene, Diaz, Dolores, Henne, Kirk R., Watts, Ryan J., Henry, Anastasia G., Gunasekaran, Kannan, Astarita, Giuseppe, Suh, Jung H., Lewcock, Joseph W., DeVos, Sarah L., Di Paolo, Gilbert

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Progranulin deficiency leads to reduced glucocerebrosidase activity von Zhou, Xiaolai, Paushter, Daniel H, Pagan, Mitchell D, Kim, Dongsung, Nunez Santos, Mariela, Lieberman, Raquel L, Overkleeft, Herman S, Sun, Ying, Smolka, Marcus B, Hu, Fenghua

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AAV-Mediated Progranulin Delivery to a Mouse Model of Progranulin Deficiency Causes T Cell-Mediated Toxicity von Amado, Defne A., Rieders, Julianne M., Diatta, Fortunay, Hernandez-Con, Pilar, Singer, Adina, Mak, Jordan T., Zhang, Junxian, Lancaster, Eric, Davidson, Beverly L., Chen-Plotkin, Alice S.

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Plasma progranulin levels predict progranulin mutation status in frontotemporal dementia patients and asymptomatic family members von Finch, NiCole, Baker, Matt, Crook, Richard, Swanson, Katie, Kuntz, Karen, Surtees, Rebecca, Bisceglio, Gina, Rovelet-Lecrux, Anne, Boeve, Bradley, Petersen, Ronald C., Dickson, Dennis W., Younkin, Steven G., Deramecourt, Vincent, Crook, Julia, Graff-Radford, Neill R., Rademakers, Rosa

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